Article
Genetics & Heredity
Lama Hamadneh, Lara Al-Lakkis, Ala A. Alhusban, Shahd Tarawneh, Bashaer Abu-Irmaileh, Sokiyna Albustanji, Abdel Qader Al-Bawab
Summary: This study investigated the role of lactate dehydrogenase (LDH) in tamoxifen resistance development, finding an upregulation of LDHB gene expression and an associated increase in lactate concentration. This suggests a potential link between LDH gene expression and tamoxifen resistance in breast cancer.
Article
Oncology
Jin Wang, Hailin Tang, Kanhua Yin, Xing Li, Xiaoming Xie, Kevin S. Hughes
Summary: After breast-conserving therapy, patients may experience ipsilateral breast tumor recurrence, new primary tumor, or contralateral breast cancer. Patients with true recurrence have poorer survival outcomes compared to those with new primary tumors, while the survival outcomes of contralateral breast cancer are better.
Article
Multidisciplinary Sciences
Changsong Wang, Ke Li, Junling An, Xuexia Lv, Wenfeng Ma, Yaxi Wang, Nianlong Meng, Tian Yun, Ting Zhao
Summary: The expression and relationship between ASPP family members and clinic-pathologic features in breast cancer were studied. The results showed that ASPP1, ASPP2, and iASPP were expressed in tumor cells, with ASPP1 expression being related to tumor stage and ASPP2 expression being related to tumor grade. ASPP1 positive expression was also associated with survival rate.
Article
Oncology
June Pui Yin Lee, Annamarie Jacob Thomas, Siew Kheong Lum, Noor Hasni Shamsudin, Ling-Wei Hii, Chun-Wai Mai, Shew-Fung Wong, Chee-Onn Leong
Summary: The study revealed that giant fibroadenomas are biologically distinct from usual fibroadenomas of the breast, showing overexpression of genes involved in the regulation of cell growth and immune response.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Aatish Thennavan, Susana Garcia-Recio, Siyao Liu, Xiaping He, Charles M. Perou
Summary: Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive ductal carcinoma (IDC). This study utilizes mouse models and human samples to identify features associated with DCIS progression. The analysis reveals malignant cells and tumor microenvironmental changes in DCIS and IDC, and suggests the existence of intrinsic subtype unique DCIS features. The findings may contribute to the identification and treatment of progression-prone DCIS in human basal-like breast cancers.
Article
Oncology
Fangyuan Chen, Kai Ding, Nolan Priedigkeit, Ashuvinee Elangovan, Kevin M. Levine, Neil Carleton, Laura Savariau, Jennifer M. Atkinson, Steffi Oesterreich, Adrian V. Lee
Summary: This study revealed transcriptional heterogeneity in breast cancer cell lines and the significant role of E-cadherin depletion in contributing to the molecular features of invasive lobular breast carcinoma.
Article
Biotechnology & Applied Microbiology
Tian-Jian Yu, Ding Ma, Ying-Ying Liu, Yi Xiao, Yue Gong, Yi-Zhou Jiang, Zhi-Ming Shao, Xin Hu, Gen-Hong Di
Summary: This study reveals the heterogeneity in energy metabolism of breast cancer through integrative analyses of multiple datasets. Energy-related metabolic signatures can stratify tumors into different prognostic clusters, reflecting the intertumoral metabolic heterogeneity. Furthermore, it is found that the metabolic status of malignant cells at single-cell resolution plays a significant role, while interactions with factors from the tumor microenvironment are unexpected.
Article
Multidisciplinary Sciences
Avisek Majumder, Manbir Sandhu, Debarko Banerji, Veronica Steri, Adam Olshen, Mark M. Moasser
Summary: HER2-amplified cancers are dependent on HER2 across different cancer types, with the level of addiction linked to the expression level of HER2 rather than HER3. The expression and phosphorylation of HER3 vary in HER2-amplified cancer cells from different tissues, and HER3 plays an essential role in tumorigenic growth in some tumors. More biomarkers will be needed to guide the optimal use of HER3 inhibitors in HER2-amplified cancers from non-breast origin.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Emmanuelle Jacquet, Florent Chuffart, Anne-Laure Vitte, Eleni Nika, Mireille Mousseau, Saadi Khochbin, Sophie Rousseaux, Ekaterina Bourova-Flin
Summary: This study identified five biomarkers that are predictive of disease-free survival in breast cancer patients, using an unbiased analysis of tissue-specific gene activations. Based on these findings, a Gene Expression Classifier was created, which can stratify and predict outcomes for breast cancer patients.
Article
Nutrition & Dietetics
Bin Guo, Hui Shu, Ling Luo, Xiangpeng Liu, Yue Ma, Jie Zhang, Zhiwei Liu, Yong Zhang, Lei Fu, Tongxing Song, Yixue Qiao, Chi Zhang
Summary: LDHB plays an important role in adipocyte differentiation and thermogenesis, with its levels changing under cold stimulation, and increasing LDHB levels can enhance the mitochondrial function of adipocytes under cold conditions.
Article
Biology
Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S. R. Nirzhor, Vijay Eedunuri, Tabrez A. Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K. Gupta, Benny A. Kaipparettu, Jack L. Arbiser, Manjeet K. Rao
Summary: The small molecule Carbazole Blue demonstrates inhibition of breast cancer growth and metastasis without adverse effects on normal tissue.
COMMUNICATIONS BIOLOGY
(2022)
Article
Genetics & Heredity
Niloufar Salimian, Maryam Peymani, Kamran Ghaedi, Mehrdad Hashemi, Ebrahim Rahimi
Summary: This study evaluated changes in the expression levels of collagen family genes related to EMT and metastasis in gastric, breast, and colorectal cancers, identifying COL11A1 and COL1A1 as common diagnostic biomarkers for these three types of cancer.
Article
Biology
Gaia Bianco, Mairene Coto-Llerena, John Gallon, Venkatesh Kancherla, Stephanie Taha-Mehlitz, Mattia Marinucci, Martina Konantz, Sumana Srivatsa, Hesam Montazeri, Federica Panebianco, Vijaya G. Tirunagaru, Marta De Menna, Viola Paradiso, Caner Ercan, Ahmed Dahmani, Elodie Montaudon, Niko Beerenwinkel, Marianna Kruithof-de Julio, Luigi M. Terracciano, Claudia Lengerke, Rinath M. Jeselsohn, Robert C. Doebele, Francois-Clement Bidard, Elisabetta Marangoni, Charlotte K. Y. Ng, Salvatore Piscuoglio
Summary: This study reveals the synthetic lethal interaction between GATA3 and MDM2 in ER-positive breast cancer, suggesting MDM2 inhibition as a potential therapeutic target for this subgroup of patients.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Ji Won Woo, Yul Ri Chung, Milim Kim, Hye Yeon Choi, Soomin Ahn, So Yeon Park
Summary: MDSCs play a crucial role in tumor progression through immunologic and non-immunologic mechanisms, with the marker S100A8 showing significant expression in pre-invasive and invasive breast cancers. The infiltration of S100A8+ immune cells was associated with a poorer prognosis in both early and invasive carcinomas, especially in hormone receptor-positive subgroups. Additionally, the infiltration of other immune cell subsets was higher in S100A8+ immune cell (+) group, indicating a complex interaction between different immune cell populations in breast cancer progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Negar Sadeghipour, Joseph Tseng, Kristen Anderson, Shivani Ayalasomayajula, Andrew Kozlov, Debra Ikeda, Wendy DeMartini, Sharon S. Hori
Summary: This study aimed to determine whether lesion size metrics on consecutive screening mammograms could predict the outcome of benign lesions versus malignant invasive carcinoma. The results showed that invasive breast cancers had a significantly shorter tumor volume doubling time (TVDT) compared to benign lesions.
EUROPEAN RADIOLOGY
(2023)
