Can Probiotics Reduce Inflammation and Enhance Gut Immune Health in People Living with HIV: Study Designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) Pilot Trials

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy

(2016) Camilla Tincati et al.   AIDS

The effect of probiotics on CD4 counts among people living with HIV: a systematic review

(2016) H. Miller et al.   Beneficial Microbes

Effect of Probiotics (Saccharomyces boulardii) on Microbial Translocation and Inflammation in HIV-Treated Patients

(2015) Judit Villar-García et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART

(2015) Birgitte Stiksrud et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Dysbiotic bacteria translocate in progressive SIV infection

(2015) Z Klase et al.   Mucosal Immunology

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

(2015) A M Ortiz et al.   Mucosal Immunology

Probiotics Reduce Inflammation in Antiretroviral Treated, HIV-Infected Individuals: Results of the “Probio-HIV” Clinical Trial

(2015) Gabriella d’Ettorre et al.   PLoS One

Immunomodulation of Antiretroviral Drug-Suppressed Chronic HIV-1 Infection in an Oral Probiotic Double-Blind Placebo-Controlled Trial

(2014) Otto O. Yang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Long-term Mortality in HIV-Positive Individuals Virally Suppressed for >3 Years With Incomplete CD4 Recovery

(2014) Frederik N. Engsig et al.   CLINICAL INFECTIOUS DISEASES

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1–Treated Individuals

(2014) Susana M. Fernandes et al.   JOURNAL OF INFECTIOUS DISEASES

Immuno-Virological Discordance and the Risk of Non-AIDS and AIDS Events in a Large Observational Cohort of HIV-Patients in Europe

(2014) Alexander Zoufaly et al.   PLoS One

The Semen Microbiome and Its Relationship with Local Immunology and Viral Load in HIV Infection

(2014) Cindy M. Liu et al.   PLoS Pathogens

A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

(2014) Ece A. Mutlu et al.   PLoS Pathogens

Persistent immune activation in chronic HIV infection

(2013) Reena Rajasuriar et al.   AIDS

HIV-associated chronic immune activation

(2013) Mirko Paiardini et al.   IMMUNOLOGICAL REVIEWS

Mucosal Th17 Cell Function Is Altered during HIV Infection and Is an Independent Predictor of Systemic Immune Activation

(2013) C. J. Kim et al.   JOURNAL OF IMMUNOLOGY

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

(2013) Ivan Vujkovic-Cvijin et al.   Science Translational Medicine

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

(2013) Sumathi Sankaran-Walters et al.   Biology of Sex Differences

FAO/WHO Guidelines on Probiotics

(2012) Lorenzo Morelli et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis

(2012) C J Kim et al.   Mucosal Immunology

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Microbial translocation, immune activation, and HIV disease

(2012) Nichole R. Klatt et al.   TRENDS IN MICROBIOLOGY

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

(2011) Duncan Chege et al.   AIDS

Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses

(2011) J. Capeau   CLINICAL INFECTIOUS DISEASES

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Are Th17 cells in the gut pathogenic or protective?

(2011) A Symons et al.   Mucosal Immunology

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals

(2010) Ard van Sighem et al.   AIDS

Unknown

(2010)   CLINICAL INFECTIOUS DISEASES

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

(2010) Kai Kisand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels

(2009) E J Ciccone et al.   Mucosal Immunology

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune reconstitution in the sigmoid colon after long-term HIV therapy

(2008) P M Sheth et al.   Mucosal Immunology

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE