Article
Neurosciences
Cong Wang, Teri M. Furlong, Peter G. Stratton, Conrad C. Y. Lee, Li Xu, Sam Merlin, Chris Nolan, Ehsan Arabzadeh, Roger Marek, Pankaj Sah
Summary: During recognition memory, coupled theta activity between the hippocampus and medial prefrontal cortex plays a key role in novelty discrimination, with monosynaptic connections identified as crucial for guiding behavior based on recognition memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Heung-Yeol Lim, Jae-Rong Ahn, Inah Lee
Summary: The perirhinal cortex (PER) and postrhinal cortex (POR) are two distinct systems that process nonspatial and spatial information, respectively. However, recent research suggests that these two regions may exhibit functional overlap in goal-directed behavior. In a study involving rats, it was found that both PER and POR showed selective firing for object and scene stimuli, with a higher proportion of cells in POR firing selectively for specific choice responses. The firing patterns of PER and POR were best explained when considering both stimulus and response components, indicating that stimulus-selective cells in POR were more modulated by response, while response-selective cells in PER were more influenced by object information.
Article
Neurosciences
Liisa Raud, Markus H. Sneve, Didac Vidal-Pineiro, Oystein Sorensen, Line Folvik, Hedda T. Ness, Athanasia M. Mowinckel, Hakon Grydeland, Kristine B. Walhovd, Anders M. Fjell
Summary: Memory encoding and retrieval are important processes in episodic memory, with the hippocampus playing a key role. However, the connectivity between the hippocampus and neocortex during memory processing in humans is not well understood. This study used data from two large-scale functional resonance imaging studies to identify hippocampal-cortical networks active during memory tasks. The functional connectivity maps were similar during resting state, encoding, and retrieval, and the connectivity profiles of the anterior and posterior hippocampus were stable across different states. During retrieval, the hippocampal connectivity with areas involved in recollection increased, while encoding connectivity likely reflected contextual factors.
Article
Neurosciences
Tyler Bonnen, L. K. Daniel Yamins, D. Anthony Wagner
Summary: The medial temporal lobe (MTL) is involved in memory-related behaviors, while its role in perceptual processing, particularly the involvement of the perirhinal cortex (PRC), has been a subject of debate. By utilizing a deep learning framework to simulate visual behaviors supported by the ventral visual stream (VVS) without PRC, the study found similarities between VVS-modeled and PRC-lesioned behaviors, but both were outperformed by participants with an intact PRC. This research resolves decades of inconsistent findings by situating lesion, electrophysiological, and behavioral results within a shared computational framework.
Article
Neurosciences
Maria Garcia-Bonilla, Arjun Nair, Jason Moore, Leandro Castaneyra-Ruiz, Sarah H. Zwick, Ryan N. Dilger, Stephen A. Fleming, Rebecca K. Golden, Michael R. Talcott, Albert M. Isaacs, David D. Limbrick Jr, James P. McAllister II
Summary: This study found that acquired hydrocephalus caused morphological alterations, reduced neurogenesis, and increased reactive astrocytosis in the hippocampus and perirhinal cortex.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Dingrong Guo, Haoyu Chen, Lingwei Wang, Jiongjiong Yang
Summary: Previous studies have shown the importance of the ventral medial prefrontal cortex (vmPFC) in schema-related memory. The extent of the involvement of different subregions of the hippocampus in retrieving schema-related memory is still debated, as is the modulation of functional connectivity between the vmPFC and the hippocampus by prior knowledge (PK) during memory retrieval. This study found that different brain networks associated with the vmPFC, subregions of the hippocampus, and cognitive control regions were responsible for retrieving information with high and low PK.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Katie M. Lavigne, Delphine Raucher-Chene, Michael D. Bodnar, Carolina Makowski, Ridha Joober, Ashok Malla, Alan C. Evans, Martin Lepage
Summary: This study found distinct structural brain changes associated with persistent negative symptoms (PNS) in the left medial temporal lobe (MTL) and suggests that basal ganglia alterations may contribute to PNS regardless of their etiology. Reductions in left MTL volume were most evident after 1 year of treatment, highlighting the importance of targeted early interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Sophie Nolden, Garvin Brod, Ann-Kristin Meyer, Yana Fandakova, Yee Lee Shing
Summary: This study investigated the impact of schooling on cognitive development in children aged 5-7. The results showed that memory formation in this age group relies more heavily on the medial temporal lobe than the prefrontal cortex.
Article
Neurosciences
Saana M. Korkki, Franziska R. Richter, Jon S. Simons
Summary: Neuroimaging evidence suggests that the success and precision of episodic recollection rely on distinct neural substrates, with the hippocampus critical for high-fidelity associative information representation. Shared cortical encoding mechanisms contribute to the formation of both accessible and precise memory representations.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Claudia C. C. Pinizzotto, Katherine M. M. Dreyer, Oluwagbohunmi A. A. Aje, Ryan M. M. Caffrey, Keertana Madhira, Mary F. F. Kritzer
Summary: Cognitive impairments in Parkinson's disease (PD) have a high prevalence and lack of effective treatments. This study investigated the suitability of Pink1 knockout rats for studying cognitive decline in PD. The findings suggest that Pink1 gene knockout negatively impacts brain circuits and/or neurochemical systems involved in object recognition tasks. This research provides new insights into the neural basis of cognitive deficits in PD and may accelerate the discovery of better treatment options.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Neurosciences
Cen Yang, He Chen, Yuji Naya
Summary: For living organisms, acquiring information about the external space is crucial for future actions. This review focuses on the brain mechanisms in nonhuman primates that link self-referenced and allocentric spatial representations. It proposes two types of neural substrates - view-center background signals and hippocampal neurons' dynamic activity - that facilitate the translation of stored location memory from an allocentric frame to a first-person perspective.
Article
Multidisciplinary Sciences
Thays Brenner Santos, Juliana Carlota Kramer-Soares, Cesar Augusto de Oliveira Coelho, Maria Gabriela Menezes Oliveira
Summary: This study investigates the effect of time intervals between conditioned and unconditioned stimuli in fear conditioning. By analyzing the functional network in rats, the study reveals the importance of amygdala and thalamic nuclei in temporal associations.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Emily T. Cowan, Matthew Fain, Ian O'Shea, Lauren M. Ellman, Vishnu P. Murty
Summary: The study shows that novelty has an impact on brain circuits, particularly the interactions between the hippocampal-VTA circuit and cortical networks. Following exposure to novelty, functional coupling is enhanced between the right anterior hippocampus and VTA, with distinct patterns of post-novelty functional coupling enhancements observed in the anterior hippocampus and VTA, targeting task-relevant regions and large-scale networks respectively.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Julien Fiorilli, Jeroen J. Bos, Xenia Grande, Judith Lim, Emrah Duezel, Cyriel M. A. Pennartz
Summary: The perirhinal cortex plays a crucial role as a transition area between the sensory neocortex and the medial temporal lobe, involved not only in object coding and spatial processing, but also in solving feature ambiguity and processing complex stimuli. This brain region has the ability to merge different features into a single entity, flexibly deploying network circuits for various cognitive functions depending on behavioral demands.
Article
Neurosciences
Monika Riegel, Malgorzata Wierzba, Marek Wypych, Maureen Ritchey, Katarzyna Jednorog, Anna Grabowska, Patrik Vuilleumier, Artur Marchewka
Summary: Recent research has found that the amygdala plays an important role in the reinstatement of emotional memories. Specifically, the amygdala has a stronger impact on the reinstatement of disgust memories. Additionally, differences in memory performance and neural mechanisms were observed, with the amygdala and perirhinal cortex more active during encoding of disgust-related events, and the hippocampus and parahippocampal gyrus more active during encoding of fear-related events.