Journal
HEPATOLOGY RESEARCH
Volume 47, Issue 3, Pages E104-E112Publisher
WILEY
DOI: 10.1111/hepr.12734
Keywords
inflammation progression; non-obese adults; non-alcoholic fatty liver disease; uric acid
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Funding
- Natural Science Foundation of Zhejiang Province [LY14H070004, LR15H030001]
- National Natural Science Foundation of China [81100278, 81470838]
- International Science and Technology Cooperation Projects of Zhejiang Province [2013C24010]
- Science Foundation of Health Bureau of Zhejiang Province [2012RCA026, 2013C33187]
- Wang Baoen Liver Fibrosis Foundation [CFHPC20131041]
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AimThis study aimed to evaluate the relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) in non-obese adults. MethodsA cross-sectional study was carried out among 4098 adults, including 1936 non-obese and 2162 obese individuals. An additional 93 non-obese adults with biopsy-proven NAFLD were also included. ResultsThe overall prevalence of NAFLD was 39.51% in the study group, and 14.88% in non-obese adults. The NAFLD patients had significantly higher SUA levels than controls in both men and women. The non-obese group had a higher NAFLD risk with increased SUA levels than the obese group, with odd ratios (95% confidence interval) of 2.559 (1.870-3.503) and 1.692 (1.371-2.087), respectively. In 93 non-obese adults with biopsy-proven NAFLD, SUA levels were significantly higher in those with non-alcoholic steatohepatitis. The prevalence of non-alcoholic steatohepatitis and lobule inflammation tended to increase to 57.58% and 66.67% as the SUA level increased to the fourth quartile. Subjects with hyperuricemia had significantly higher NAFLD activity scores and more serious lobule inflammation than the normal group. ConclusionNon-obese adults have higher NAFLD risk with increased SUA levels than obese individuals, and the inflammation progression of NAFLD is associated with increased SUA level in non-obese subjects.
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