Review
Dentistry, Oral Surgery & Medicine
Oscar Iglesias-Velazquez, Rosa Maria Lopez-Pintor, Jose Gonzalez-Serrano, Elisabeth Casanas, Jesus Torres, Gonzalo Hernandez
Summary: This study evaluated the increase in salivary lactate dehydrogenase (LDH) levels in patients with oral cancer (OC) or oral potentially malignant disorders (OPMD) compared to a healthy control group (CG). Results showed that LDH levels were higher in the OC group and patients with oral leucoplakia and oral submucous fibrosis also had higher levels. Salivary LDH determination may be a useful method for screening and tracking OC and OPMD, but further studies are needed to establish precise cutoff values.
Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pathology
Nadisha S. Piyarathne, R. M. S. G. K. Rasnayake, Randilini Angammana, Pushpika Chandrasekera, Samantha Ramachandra, Manjula Weerasekera, Surangi Yasawardene, Rasha Abu-Eid, J. A. P. Jayasinghe, Ekta Gupta
Summary: This systematic review focused on selecting a panel of salivary biomarkers for early detection of OSCC and OPMD, as well as assessing their relationships with risk factors. Salivary biomarkers could play a significant role in future early disease detection, but further research is needed to fully understand their potential impact.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Engineering, Biomedical
Xing Wang, Zuoying Yuan, Anqi Tao, Pudi Wang, Wenyue Xie, Shuo Yang, Jianyong Huang, Ning Wen
Summary: This study introduces a novel hydrogel patch that effectively treats oral potentially malignant disorders and improves patient comfort. Through experiments and modeling, the feasibility and clinical value of this hydrogel patch have been demonstrated.
Article
Biotechnology & Applied Microbiology
Hao Yang, Zhenfei Wang, Shujun Shi, Qin Yu, Meiling Liu, Zhelin Zhang
Summary: This study demonstrated that CSF metabolomics based on LC-MS can differentiate neurobrucellosis patients from normal controls, offering new perspectives for diagnosis and treatment of neurobrucellosis.
Review
Health Care Sciences & Services
Jewel Kai Lin See, Xinyao Liu, Federica Canfora, Caroline Moore, Michael Mccullough, Tami Yap, Rita Paolini, Antonio Celentano
Summary: This study systematically reviewed the evidence on the therapeutic effects of vitamin supplementation for oral potentially malignant disorders (OPMDs) and oral cancer (OC). The results showed that vitamin K, vitamin C, vitamin A, vitamin B, and vitamin D all had therapeutic benefits. The research on oral cancer was extensive, with a focus on oral lichen planus and oral leukoplakia among the OPMDs. However, standardizing the study design and outcomes is needed to enhance future research.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gerardo Gilligan, Rene Panico, Jeronimo Lazos, Rosana Morelatto, Paola Belardinelli, Ines Criscuolo, Nicolas Bolesina, Ignacio Molina Avila, Juan Martin Pimentel Sola, Emilce Rivarola, Maria Jimena Morgante, Maria Eugenia Ingrassia Tonelli, Javier Gimenez, Pablo Doratti, Laura Cecilia Werner, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Aljomar Jose Vechiato-Filho, Maria Claudia Cuzzullin, Cristina Saldivia-Siracusa, Marcio Ajudarte Lopes, Michelle Agostini, Mario Jose Romanach, Aline Correa Abrahao, Thamyres Campos Fonseca, Estela Kaminagakura, Ana Lia Anbinder, Kamilla Santos Alves, Maria Leticia de Almeida Lanca, Sonia Sacsaquispe-Contreras, Karem Rodriguez Ibazetta, Roberto Gerber-Mora, Saray Aranda Romo, Francisco Javier Tejeda Nava, Karina Cordero-Torres, Ricardo Moreno Silva, Wilfredo Gonzalez-Arriagada, Raiza Toro, Felipe Martins Silveira, Natalia Gonzalez, Pablo Agustin Vargas, Alan Roger Santos-Silva, Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Benjamin Martinez, Eduardo Piemonte
Summary: This study aims to investigate the frequency, epidemiological profile, and traditional risk factors of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD) in Latin America. The results suggest that OSCC-dn is more frequent in Latin America, with regional variations in some clinical and histopathological features.
Article
Chemistry, Analytical
Fei-Long Liu, Tian-Tian Ye, Jiang-Hui Ding, Xiao-Ming Yin, Xiao-Ke Yang, Wei-Hua Huang, Bi-Feng Yuan, Yu-Qi Feng
Summary: Researchers synthesized paired reagents of DMPI and d(3)-DMPI, which can efficiently react with phosphate groups on polar phosphorylated metabolites. They found that tagging DMPI onto ribonucleotides significantly increased ionization efficiencies during LC/MS analysis, resulting in enhanced detection sensitivities.
ANALYTICAL CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nabihah Haron, Senthilmani Rajendran, Thomas George Kallarakkal, Rosnah Binti Zain, Anand Ramanathan, Mannil Thomas Abraham, Shin Hin Lau, Lai Choo Cheng, Sherrie Mei Yee Chong, Farah Aliya Mohamed Azahar, Zuraiza Mohamad Zaini, Siew Wui Chan, Yet Ching Goh, Daniel Lim, Juliana Khairi, Marzuki Zainal Abidin, Zainal Ariff Abdul Rahman, Chee Sun Liew, Siew Chinn Fong, Yi-Hsin Yang, Siti Mazlipah Ismail, Sok Ching Cheong
Summary: This study evaluated the accuracy of a mobile phone application called MeMoSA (R) in reviewing images of oral lesions, and found that it is a reliable telemedicine tool for identifying high-risk lesions for early management, comparable to clinical examination.
Review
Biochemistry & Molecular Biology
Shuzhi Deng, Shimeng Wang, Xueke Shi, Hongmei Zhou
Summary: This article explores the changes and interactions of microenvironments in Oral Potentially Malignant Disorders (OPMDs) and their relationship with carcinogenesis mechanisms. The authors propose an immuno-metabolic-mechanical-neural interaction network and summarize therapeutic strategies targeting microenvironments. These studies contribute to preventing the carcinogenesis of OPMDs and provide new research directions and clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sachika Shiraishi, Masahiro Sugimoto, Koichi Tokuuye
Summary: The study evaluated salivary metabolomics as an independent predictor for radiation pneumonitis, identifying three metabolites with predictive ability for clinical RP.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Marko Tarle, Danko Muller, Marina Raguz, Ivica Luksic
Summary: This study investigated the expression of nuclear EGFR (nEGFR) and the stem cell marker ABCG2 in oral leukoplakia and oral erythroplakia, and found that co-expression of both biomarkers was associated with an increased risk of malignant transformation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemistry & Molecular Biology
Adamantios Krokos, Olga Deda, Christina Virgiliou, Helen Gika, Nikolaos Raikos, Eleni Aggelidou, Aristeidis Kritis, Georgios Theodoridis
Summary: This study evaluated the effect of cocaine on human liver cancer cell lines and revealed the predominant impact of cocaine on the metabolic pathways of alanine, aspartate, and glutamate. Targeted metabolomics identified changes in metabolites upon cocaine administration, but deciphering the exact cocaine cytotoxic mechanism remains challenging.
Article
Oncology
Pia Lopez-Jornet, Aitana Olmo-Monedero, Camila Peres-Rubio, Eduardo Pons-Fuster, Asta Tvarijonaviciute
Summary: Early diagnosis of potentially malignant oral disorders is crucial for reducing oral cancer mortality. This study analyzed a panel of salivary markers and found that ferritin and total proteins may serve as potential salivary biomarkers for diagnosis. Additionally, saliva tests are reliable and non-invasive diagnostic tools that offer an interesting alternative for screening large populations.
Review
Oncology
Luigi Lorini, Coro Bescos Atin, Selvam Thavaraj, Urs Mueller-Richter, Margarita Alberola Ferranti, Jorge Pamias Romero, Manel Saez Barba, Alba de Pablo Garcia-Cuenca, Irene Brana Garcia, Paolo Bossi, Paolo Nuciforo, Sara Simonetti
Summary: Oral potentially malignant disorders (OPMDs) are a group of oral mucosal diseases that have the potential to develop into oral squamous cell carcinoma (OSCC). Early diagnosis is crucial for improving survival rates. The focus is on early detection techniques and the effectiveness of treatments.
Article
Dentistry, Oral Surgery & Medicine
Deepa Jatti, Gagan Puri, Konidena Aravinda, Dhavneet Singh Dheer
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2015)
Article
Dentistry, Oral Surgery & Medicine
Ravleen Nagi, B. K. Yashoda Devi, N. Rakesh, Sujatha S. Reddy, Deepa Jatti Patil
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2015)
Review
Dentistry, Oral Surgery & Medicine
Aravinda Konidena, Samridhi Shekhar, Avani Dixit, Deepa Jatti Patil, Rajesh Gupta
Review
Dentistry, Oral Surgery & Medicine
Ravleen Nagi, Deepa Jatti Patil, Shashikant Sahu, Supreet Jain, Giridhar S. Naidu
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
N. Rakesh, B. K. Yashoda Devi, Deepa Jatti Patil, Ravleen Nagi
Article
Medicine, Legal
Deepa Jatti, Yashodadevi Kantaraj, Rakesh Nagaraju, Sujatha Janardhan, Santana Nataraj
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2013)
Review
Pharmacology & Pharmacy
Deepa Jatti Patil
Summary: Vitamin D deficiency not only affects systemic health, but also has implications on oral health for both children and adults. Studies show that supplementing with Vitamin D during pregnancy and afterwards has positive effects on oral health for mothers and children. Vitamin D deficiency can lead to poor tooth mineralization, defects in enamel and dentin, and an increased risk of cavities.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Review
History & Philosophy Of Science
Rashmi Venkatesh, Palak H. Shah, Chandramani B. More, Deepa J. Patil
Summary: Oral Submucous Fibrosis (OSF) is an age-old disease associated with the habit of using Areca nut. The pathogenesis of this irreversible disease is complex and none of the current treatment modalities have been satisfactory. This article attempts to trace the history of OSF by providing insights into the cultivation and cultural aspects of Areca nut, as well as the psychology behind its use in various cultures and a review of current medical literature.
INDIAN JOURNAL OF HISTORY OF SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Neha Koshal, Deepa Jatti Patil, Sanjeev Laller, Mamta Malik, Ramandeep Singh Punia, Hemant Sawhney
Summary: This study found that there was no direct correlation between bone quality type and degenerative bone changes in temporomandibular joints, but most patients with poor bone quality had degenerative changes.
JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ajay Pal Singh Kataria, Aravinda Konidena, Gagan Puri, Deepa Jatti Patil, Rajesh Gupta
JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY
(2020)
Article
Surgery
Deepa Jatti Patil, Chandramani B. More, Rashmi Venkatesh, Palak Shah
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Tarun Kumar, Neha Arora, Gagan Puri, Konidena Aravinda, Avani Dixit, Deepa Jatti
CONTEMPORARY CLINICAL DENTISTRY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Sampangi Sujatha, Deepa Jatti
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2015)
Article
Dentistry, Oral Surgery & Medicine
Deepa J. Patil, Rahul Thakur, Manjiri Joshi, Rashmi Phulare
JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jose Wilson Noleto, Nathalie Murielly Rolim de Abreu, Raissa Leitao Guedes, Pollianna Muniz Alves, Pedro Paulo de Andrade Santos
Summary: This study describes a rare case of cystic calcifying epithelial odontogenic tumor (CEOT). The tumor presented as a mixed radiolucent-radiopaque lesion in the posterior region of the maxilla, accompanied by a missing upper second molar. Histopathological examination revealed calcification in the fibrous capsule of the cystic lesion, as well as other characteristic features.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Mari Shibata, Hiroyuki Yoshitake, Kou Kayamori, Tohru Ikeda, Motoko Seki, Tetsuya Yoda
Summary: Neoplastic lesions in the oral and maxillofacial regions of infants are rare, and a definitive diagnosis based on histopathological examination should be considered for cases that are difficult to diagnose clinically and radiographically.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Takasuke Usuki, Kohei Kawamura, Takayuki Kurimoto, Hironobu Kobashi, Kanemitsu Shirasuna, Hideo Yoshioka
Summary: Intramuscular lipoma is rare in the oral region, and its cause is unknown. This report presents a case of intramuscular lipoma-like lesion in the right cheek. The use of REGROTH (R) in the surgical procedure may be involved in tumor development.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Katsuhisa Sekido, Minami Asakura, Hidetake Tachinami, Makoto Noguchi
Summary: This report presents a case of T-cell dominant polymorphic lymphoproliferative disorder associated with periimplantitis due to long-term methotrexate administration. The patient experienced relief from pain after methotrexate withdrawal, but bone exposure persisted.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junya Kusumoto, Yuka Hayase, Yuriko Susukida, Takumi Sato, Akiko Sakakibara, Masaya Akashi
Summary: Refractory osteomyelitis can lead to complications in advanced mandibular osteoradionecrosis (ORN), such as recurrent cellulitis and pathological fractures. The optimal treatment for such conditions has not been established yet. Difficulty in intake and severe pain caused by mandibular ORN may result in malnutrition and underweight. Refeeding syndrome (RFS) should be considered in invasive surgical procedures.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Amir Taherkhani, Golnaz Moradifar, Zeynab Bayat, Pouria Samadi, Shokoofeh Jamshidi
Summary: An integrated bioinformatics analysis was performed to determine key genes and pathways in the malignant transformation of oral leukoplakia to primary OSCC. Validation study confirmed the upregulation of PLAU, SERPINE1, and SPP1 in primary OSCC.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Kotoko Imai, Takanori Sugiura, Miki Sato, Homare Kawachi
Summary: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a progressive mitochondrial disease characterized by multiple cerebral infarctions, muscle weakness, neuropathy, intellectual regression, and other symptoms. This study reports a case of a diabetic patient with MELAS who underwent oral treatment for weakened facial muscles, showing good progress initially but later refusing treatment and experiencing rapid deterioration leading to death.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Sachiko Yamasaki, Ryouji Tani, Souichi Yanamoto
Summary: Cranial base invasion can have a serious impact on patients' quality of life. However, a combination chemotherapy regimen of nivolumab followed by cetuximab and paclitaxel has shown promising efficacy in treating recurrent lip cancer with skull base invasion, achieving complete response.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Suguru Hirota, Yukio Yoshioka, Fumitaka Obayashi, Sachiko Yamasaki, Koichi Koizumi, Souichi Yanamoto
Summary: This study identified new molecular and histopathological features of the malignant transformation of proliferative verrucous leukoplakia. The results showed the important role of Wnt-related oncogenes and the suppressing effect of the p53-p21 signaling pathway on carcinogenesis in the precancerous stage.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Seiji Baba, Kyoko Ishimaru, Eiji Ito, Saki Goto, Keizo Kato, Yoichi Yamada
Summary: This article reports a rare case of leiomyosarcoma metastasizing to the sublingual region, which underwent multiple resection surgeries. No tumor recurrence was observed in the sublingual region after the surgeries.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Safa Motevasseli, Niousha Roudbari, Zahra Dalili Kajan, Armin Gholamhosseinzadeh, Melika Roudbari, Emad Taghizadeh, Bahram Darbandi
Summary: This case describes a 9-year-old boy with a mass in the palatal and buccal aspect of the left maxillary alveolar ridge. He was diagnosed with Burkitt lymphoma, with visceral involvement. The maxillofacial surgeon excised the maxillary mass and the patient received chemotherapy.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Masato Narita, Masae Yamamoto, Takashi Takaki, Masashi Iwamoto, Mamoru Wakoh, Takashi Yakushiji, Akira Katakura, Masayuki Takano, Takashi Kamio
Summary: This study reviews the diseases detected as incidental findings (IFs) during TMJ MR imaging and provides case reports including the detection of IFs.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Takumi Sato, Eri Kitaya, Katsumitsu Shimada, Michiko Yoshizawa, Yuji Kurihara, Hiromasa Hasegawa
Summary: Hobnail hemangioma is a rare vascular tumor that typically occurs in young or middle-aged individuals. This study reports an unusual case of hobnail hemangioma on the tongue with pyogenic granuloma-like appearances. The patient underwent successful surgery and showed no recurrence after 2 years.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Christina Matl, Lacey Durham, Borislav A. Alexiev, James C. Wang
Summary: This article presents an extremely rare case of an adult supraclavicular lymphangioma. The patient underwent surgical removal of a cystic mass in the supraclavicular region, which was confirmed to be a cavernous lymphangioma through histopathology. Although supraclavicular lymphangiomas in adulthood are uncommon, they should not be disregarded as a potential cause of supraclavicular masses.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Masashi Tamura, Yasutaka Hoshimoto, Shohei Seta, Yasuhiro Nakanishi, Masashi Sasaki, Takayuki Aoki, Kazunari Karakida, Yoshihide Ota
Summary: Osteoblastoma is a rare bone tumor that often occurs in the maxillofacial region, primarily the posterior mandible. Swelling and pain are common symptoms, but some cases are asymptomatic. Diagnosis can be challenging due to similarities with other diseases. Complete resection is the preferred treatment.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2024)
