Article
Microbiology
Kimberly Sanchez-Alonzo, Libnny Belmar, Cristian Parra-Sepulveda, Humberto Bernasconi, Victor L. Campos, Carlos T. Smith, Katia Saez, Apolinaria Garcia-Cancino
Summary: The study found that amoxicillin significantly increased the entry of H. pylori into C. albicans cells, suggesting a negative impact on the success of treatment.
Review
Infectious Diseases
Antonio Mestrovic, Nikola Perkovic, Ante Tonkic, Zeljko Sundov, Marko Kumric, Josko Bozic
Summary: The increase in antibiotic resistance to H. pylori has led to a decrease in the effectiveness of eradication therapy. Tailored therapy based on sensitivity tests to antibiotics is proving to be a superior option, even as a first-line therapy. Using a susceptibility-guided strategy and PCR technology can further optimize the eradication process.
Article
Medicine, General & Internal
Gracia Ma Martin-Nunez, Isabel Cornejo-Pareja, Mercedes Clemente-Postigo, Francisco J. Tinahones, Isabel Moreno-Indias
Summary: Eradication treatment for H. pylori leads to changes in gut microbiota composition and a decrease in ghrelin levels. Specific gut bacteria have been linked to changes in ghrelin levels, suggesting a potential role in the regulation of ghrelin.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
A. Sofia Pinho, Catarina L. Seabra, Claudia Nunes, Salette Reis, M. Cristina Martins, Paula Parreira
Summary: Bacterial biofilms, including those formed by Helicobacter pylori, are highly resistant to antibiotics. This study found that nanostructured lipid carriers (NLC) can effectively reduce biofilm biomass and kill both biofilm and planktonic bacteria of H. pylori. Additionally, the combination of docosahexaenoic acid (DHA) and NLC showed a synergistic effect in treating H. pylori biofilms.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Gastroenterology & Hepatology
Antonia Valeria Borraccino, Francesca Celiberto, Maria Pricci, Bruna Girardi, Andrea Iannone, Maria Rendina, Enzo Ierardi, Alfredo Di Leo, Giuseppe Losurdo
Summary: When multiple Helicobacter pylori eradication treatments fail, a rifabutin-based regimen could be a viable alternative, as it demonstrates a low antibiotic resistance rate and high eradication rates when used in combination with amoxicillin or other antibiotics. However, caution should be exercised as rifabutin is commonly used for treating tuberculosis and may promote antibiotic resistance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Andrea Beer, Helmut Hudler, Maria Hader, Michael Kundi, Susanne Hudler, Valentina Taeuber, Helga Schachner, Sophie Gruber, Alexander M. Hirschl, Renate Kain, Athanasios Makristathis
Summary: The study investigated the impact of intracellular Helicobacter pylori on treatment failure, especially in the AC/PPI group. The results showed that both aiHp and resistance to clarithromycin were significant predictors of eradication failure in first-line triple therapies.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ana Bacic, Vladimir Milivojevic, Isidora Petkovic, Dusan Kekic, Ina Gajic, Branislava Medic Brkic, Dusan Popadic, Tomica Milosavljevic, Mirjana Rajilic-Stojanovic
Summary: This study aimed to evaluate the presence of antibiotic resistance genes in Helicobacter pylori and the presence of Candida spp. in gastric biopsies of H. pylori-positive patients, as well as their relationship. Real-time PCR was used to detect and identify Candida yeasts and mutations specific for clarithromycin and fluoroquinolones in DNA extracted from gastric biopsy samples of 110 H. pylori-positive participants. The resistance rates to clarithromycin and fluoroquinolone were 52% and 47%, respectively. Antibiotic resistance was associated with more eradication attempts (p < 0.05). Candida species were detected in 8.18% of the patients. The presence of Candida was associated with older age (p < 0.05). High antibiotic resistance was observed, while the presence of Candida was scarce, indicating that endosymbiosis between H. pylori and Candida may not be a major contributing factor to the eradication failure. However, older age favored colonization of Candida in the gastric mucosa, which could contribute to gastric pathologies and microbiome dysbiosis.
Review
Gastroenterology & Hepatology
Shailja C. Shah, Adam Tepler, Cecilia P. Chung, Giovanni Suarez, Richard M. Peek, Adriana Hung, Christianne Roumie, Neeraj Narula
Summary: This meta-analysis study identified host genetic polymorphisms significantly associated with H pylori eradication failure, particularly among treatment-adherent individuals with confirmed H pylori antibiotic susceptibility. CYP2C19 polymorphisms, especially metabolizer phenotypes, were strongly associated with eradication failure risk. IL1B polymorphisms related to gastric acid suppression were also linked to eradication failure risk.
Review
Medicine, General & Internal
Vaneet Jearth, Mitali Madhumita Rath, Abhirup Chatterjee, Aditya Kale, Manas Kumar Panigrahi
Summary: Helicobacter pylori is a common chronic bacterial infection affecting half of the world's population. It is classified as a Class I carcinogen and is linked to the majority of stomach cancer cases worldwide. Antibiotic resistance in H. pylori is a major public health concern and a leading cause of eradication failure. This review provides an overview of H. pylori antibiotic resistance patterns, mechanisms, and clinical implications, as well as a discussion on current testing methods and evidence-based approaches to treatment.
Review
Microbiology
Brian White, Maria Winte, Joshua DeSipio, Sangita Phadtare
Summary: Helicobacter pylori is a common gastric pathogen associated with multiple clinical syndromes, and its antibiotic resistance is the main reason for the suboptimal eradication rates. Although there is a molecular testing technology to identify antibiotic-resistant H. pylori, it is currently limited by availability and cost. There is currently insufficient evidence to demonstrate the superiority of resistance-testing-based treatment approaches over empiric strategies. Clinicians can choose the most appropriate treatment strategy based on factors such as medical history, age, gender, ethnicity, alcohol use, and symptoms.
Article
Gastroenterology & Hepatology
Shria Kumar, David C. Metz, David E. Kaplan, David S. Goldberg
Summary: This study found low rates of retesting for Helicobacter pylori infection after eradication treatment in the VHA patient cohort. There was significant variation in retesting rates among VHA facilities, and two-thirds of H. pylori testing was ordered by non-gastroenterology specialists.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Giuseppe Losurdo, Maria Pricci, Margherita De Bellis, Francesca Celiberto, Francesco Russo, Giuseppe Riezzo, Benedetta D'attoma, Andrea Iannone, Maria Rendina, Enzo Ierardi, Alfredo Di Leo
Summary: The study evaluated the impact of metronidazole resistance on the eradication therapy of H. pylori and found that metronidazole resistance does not affect the eradication rates of BQT and CT regimens in our geographical area.
JOURNAL OF DIGESTIVE DISEASES
(2022)
Article
Oncology
Fansen Meng, Hongjin Tao, Yan Mi, Tianyu Yang, Xuanping Wang, Yuyo Go, Yunjuan Lin, Gangshi Wang
Summary: In this study, nanoclusters (NCs) were developed from Zn0.3Fe2.7O4 nanoparticles as an innovative antibiotic-independent H. pylori management. The NCs exhibited efficient photothermal effects, resulting in significant inhibition of H. pylori growth and molecular toxicity in vitro. Furthermore, the NCs reduced antibiotic resistance and biofilm formation in H. pylori.
CANCER NANOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sara Gabriela Cifuentes, Maria Belen Prado, Marco Fornasini, Henry Cohen, Manuel Eduardo Baldeon, Paul Andres Cardenas
Summary: This study found that the addition of Saccharomyces boulardii to antibiotic therapy significantly reduced the abundance of antimicrobial resistance genes (ARGs) in the gut, particularly those genes that confer resistance to lincosamides, tetracyclines, MLS-B, and a few genes in the beta-lactams class.
Article
Infectious Diseases
Jinliang Xie, Dingwei Liu, Jianxiang Peng, Shuang Wu, Dongsheng Liu, Yong Xie
Summary: This study investigates the iatrogenic factors related to H. pylori eradication failure and finds that a high proportion of patients used antibiotics with high resistance rates in both first-line and rescue treatments. To reduce the risk of H. pylori eradication failure, more attention should be paid to iatrogenic factors, and treatment regimens should be standardized to improve the eradication rate.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)