Article
Cardiac & Cardiovascular Systems
Karl-Heinz Kuck, Dmitry S. Lebedev, Evgeny N. Mikhaylov, Alexander Romanov, Laszlo Geller, Oskars Kalejs, Thomas Neumann, Karapet Davtyan, Young Keun On, Sergey Popov, Maria Grazia Bongiorni, Michael Schlueter, Stephan Willems, Feifan Ouyang
Summary: The study indicates that radiofrequency ablation is more effective than antiarrhythmic drug therapy in delaying the progression from paroxysmal to persistent atrial fibrillation. Patients aged 65 and above may have an increased risk of progressing to persistent atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Josef Kautzner, Jean-Paul Albenque, Andrea Natale, William Maddox, Frank Cuoco, Petr Neuzil, Herve Poty, Michael K. Getman, Shufeng Liu, Zdenek Starek, Srinivas R. Dukkipati, B. Judson Colley, Amin Al-Ahmad, Darren S. Sidney, H. Thomas McElderry
Summary: The Diamond-AF trial demonstrated that the DiamondTemp Ablation system is noninferior in safety and efficacy to a force-sensing RF ablation system for the treatment of paroxysmal atrial fibrillation. Efficiency improvements were also observed with the DTA system.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rongfeng Zhang, Huimin Chu, Shaowen Liu, Bing Yang, Bing Han, Xianjie Xiao, Chengming Ma, Yuanjun Sun, Xiaomeng Yin, Yunlong Xia, Lianjun Gao
Summary: The use of contact force sensing catheters has improved catheter ablation of atrial fibrillation, but there are still limitations and complications. The FireMagic force-sensing ablation catheter demonstrated feasibility and satisfactory short- and long-term efficacy and safety in atrial fibrillation catheter ablation.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Physiology
Fares-Alexander Alken, Katharina Scherschel, Ann-Kathrin Kahle, Mustafa Masjedi, Christian Meyer
Summary: The study aimed to investigate the dynamics of contact force (CF) and local impedance (LI) in patients with previous atrial fibrillation (AF) ablation. The results showed that the combination of CF and LI can aid in monitoring the catheter-tissue electro-mechanical coupling and lesion formation during ablations.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Samuel K. Sorensen, Arne Johannessen, Rene Worck, Morten L. Hansen, Jim Hansen
Summary: Radiofrequency and cryoballoon catheter ablation demonstrate similar moderate to high durability in pulmonary vein isolation. However, about 5% of patients experienced recurrence of atrial fibrillation despite complete and durable PVI. The reduction in AF burden is associated with the number of durably isolated pulmonary veins.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Derek S. Chew, Yanhong Li, Patricia A. Cowper, Kevin J. Anstrom, Jonathan P. Piccini, Jeanne E. Poole, Melanie R. Daniels, Kristi H. Monahan, Linda Davidson-Ray, Tristram D. Bahnson, Hussein R. Al-Khalidi, Kerry L. Lee, Douglas L. Packer, Daniel B. Mark
Summary: In the CABANA trial, catheter ablation was found to be economically attractive compared with drug therapy for treating atrial fibrillation, based on projected incremental quality-adjusted life years (QALYs) but not life years (LYs) alone.
Article
Medicine, General & Internal
Nassir F. Marrouche, Oussama Wazni, Christopher McGann, Tom Greene, J. Michael Dean, Lilas Dagher, Eugene Kholmovski, Moussa Mansour, Francis Marchlinski, David Wilber, Gerhard Hindricks, Christian Mahnkopf, Darryl Wells, Pierre Jais, Prashanthan Sanders, Johannes Brachmann, Jeroen J. Bax, Leonie Morrison-de Boer, Thomas Deneke, Hugh Calkins, Christian Sohns, Nazem Akoum
Summary: Among patients with persistent atrial fibrillation, MRI-guided fibrosis ablation in addition to PVI did not show significant reduction in atrial arrhythmia recurrence compared to PVI catheter ablation alone. The findings do not support the use of MRI-guided fibrosis ablation for the treatment of persistent AF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
Ying Lin, Xian Wang, Xue-Bin Li, Bang-Qi Wu, Zhao-Hui Zhang, Wei-Hua Guo, Cun-Cao Wu, Xin Chen, Ming-Long Chen, Zhong Dai, Fu-Yan Chen, Rui Zhu, Chu-Xi Liang, Yun-Peng Tian, Gang Yang, Chao-Qun Yan, Jing Lu, Hai-Ying Wang, Jin-Ling Li, Jian-Feng Tu, He-Wen Li, Dan-Dan Yang, Fang-Ting Yu, Yu Wang, Jing-Wen Yang, Guang-Xia Shi, Shi-Yan Yan, Li-Qiong Wang, Cun-Zhi Liu
Summary: This pilot trial aims to evaluate the feasibility, preliminary efficacy, and safety of acupuncture in reducing AF burden for persistent AF after catheter ablation (CA) through a multi-center, 3-arm, randomized controlled trial.
Article
Cardiac & Cardiovascular Systems
Girish M. Nair, David H. Birnie, George A. Wells, Pablo B. Nery, Calum J. Redpath, Jean-Francois Sarrazin, Jean-Francois Roux, Ratika Parkash, Martin Bernier, Laurence D. Sterns, Paul Novak, George Veenhuyzen, Carlos A. Morillo, Sheldon M. Singh, Marcio Sturmer, Vijay S. Chauhan, Paul Angaran, Vidal Essebag
Summary: The AWARE trial aims to evaluate whether an augmented wide-area circumferential antral (WACA) ablation strategy can reduce the risk of atrial arrhythmia recurrence in patients with symptomatic paroxysmal AF, compared with a conventional WACA strategy.
AMERICAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Gang Chen, Guangling Li, Demei Zhang, Xiaomei Wang, Xueya Guo
Summary: Although there is a lack of large-scale, multicenter controlled studies to confirm the efficacy of antiarrhythmic drugs (AADs) in reducing the incidence of late recurrence of atrial fibrillation (AF) after catheter ablation (CA), short-term use of AADs (more than 2 months) can reduce the early recurrence risk but not the late recurrence risk after CA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mark M. Gallagher, Gang Yi, Hanney Gonna, Lisa W. M. Leung, Idris Harding, Banu Evranos, Rachel Bastiaenen, Rajan Sharma, Sue Wright, Mark Norman, Zia Zuberi, A. John Camm
Summary: The study compared the efficacy of multi-catheter cryotherapy and RF ablation in eliminating AF and restoring SR in patients with long-standing persistent atrial fibrillation. The results showed that multi-catheter cryotherapy could restore SR in more patients faster, but long-term success rates were similar to RF ablation.
Article
Cardiac & Cardiovascular Systems
Chun-Chao Chen, Po-Tseng Lee, Vu Van Ba, Chieh-Mao Chuang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Chin-Yu Lin, Ting-Yung Chang, Jennifer Jeanne Vicera, Ting-Chun Huang, Chih-Min Liu, Cheng- Wu, Isaiah C. Lugtu, Ankit Jain, Shih-Lin Chang, Shih-Ann Chen
Summary: In contact force-guided atrial fibrillation ablation, using high-power short-duration settings resulted in more type A lesions, mainly distributed in different areas, with shorter operation and ablation times, and lower recurrence rates.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Atsushi Kobori, Yasuhiro Sasaki, Misun Pak, Masahiro Ishikura, Ryosuke Murai, Taiji Okada, Toshiaki Toyota, Tomohiko Taniguchi, Kitae Kim, Natsuhiko Ehara, Makoto Kinoshita, Yasuki Kihara, Yutaka Furukawa
Summary: This study compared the effectiveness and safety of cryoballoon ablation and contact force-sensing radiofrequency ablation in Japanese patients with persistent atrial fibrillation. The results showed that cryoballoon ablation had comparable outcomes to advanced CFRF ablation, with similar rates of periprocedural complications and repeat ablation.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kwang-No Lee, Do Young Kim, Ki Yung Boo, Yun Gi Kim, Seung-Young Roh, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study compared the impact of a combined epicardial and endocardial approach with a conventional endocardial approach on recurrence-free survival in patients with persistent atrial fibrillation after prior endocardial ablation. The results showed that the combined approach had no significant difference in recurrence-free survival and had a lower procedural complication rate compared to the conventional approach.
Article
Cardiac & Cardiovascular Systems
Girish M. Nair, David H. Birnie, Pablo B. Nery, Calum J. Redpath, Jean-Francois Sarrazin, Jean-Francois Roux, Ratika Parkash, Martin Bernier, Laurence D. Sterns, John Sapp, Paul Novak, George Veenhuyzen, Carlos A. Morillo, Sheldon M. Singh, Mouhannad M. Sadek, Mehrdad Golian, Andres Klein, Marcio Sturmer, Vijay S. Chauhan, Paul Angaran, Martin S. Green, Jordan Bernick, George A. Wells, Vidal Essebag
Summary: In this study, an augmented double wide-area circumferential ablation (WACA) did not show superiority in preventing recurrent atrial arrhythmias compared to a standard single WACA in patients with paroxysmal AF. The additional ablation did not improve freedom from atrial arrhythmias or safety.
Article
Cardiac & Cardiovascular Systems
Sheng-Chia Chung, Alvina Lai, Gregory Y. H. Lip, Pier D. Lambiase, Rui Providencia
Summary: Using real-world data from the UK, this study aimed to investigate the effectiveness of anti-arrhythmic drugs and catheter ablation in improving the survival of atrial fibrillation patients. The study found that patients receiving rhythm control treatment had lower mortality rates, with pulmonary vein isolation showing the most pronounced survival benefit.
Article
Cardiac & Cardiovascular Systems
Peter H. Waddingham, Jan O. Mangual, Michele Orini, Nima Badie, Amal Muthumala, Simon Sporton, Luke C. McSpadden, Pier D. Lambiase, Anthony W. C. Chow
Summary: This study assessed the impact of dynamic AV delay programming using SyncAV on electrical dyssynchrony across various pacing modalities. The results showed that dynamic AV delay programming significantly reduced dyssynchrony for all evaluated pacing modes, with MPP + SyncAV achieving the greatest synchrony overall.
Article
Cardiac & Cardiovascular Systems
Sofia Monaci, Shuang Qian, Karli Gillette, Esther Puyol-Anton, Rahul Mukherjee, Mark K. Elliott, John Whitaker, Ronak Rajani, Mark O'Neill, Christopher A. Rinaldi, Gernot Plank, Andrew P. King, Martin J. Bishop
Summary: This study presents a non-invasive computational-deep learning platform for localizing post-infarct ventricular tachycardia. The platform utilizes surface electrocardiograms (ECGs) and intracardiac electrograms (EGMs) recorded from implanted devices to accurately locate the exit sites of the tachycardia. The results demonstrate the potential of this platform in clinical settings for enhancing the safety and speed of ablation planning.
Editorial Material
Cardiac & Cardiovascular Systems
Pier D. Lambiase, Prashantan Sanders, Harry J. G. M. Crijns
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Robert D. Anderson, Sachin Nayyar, Stephane Masse, Pier D. Lambiase, Kumaraswamy Nanthakumar
Summary: The re-emerging interest in ventricular electrophysiology and repolarization has led to the development of wave tail mapping, which can identify critical sites beyond the traditional depolarization mapping techniques. While various techniques can study diseased substrate in detail, clinical outcomes remain unchanged. Wave tail mapping has the potential to fill this gap, particularly in cases where conventional scar ablation endpoints are limited. However, there are barriers to its clinical use, and further improvements in repolarization mapping are needed.
Review
Biology
Tolga Aksu, Dhiraj Gupta, Jamario R. Skeete, Henry H. Huang
Summary: Atrial fibrillation (AF) is a common supraventricular arrhythmia associated with higher cardiovascular morbidity and mortality. Recent evidence suggests that catheter-based pulmonary vein isolation (PVI) may be a superior alternative to antiarrhythmic drug therapy for long-term freedom from AF episodes. Imbalances in the autonomic nervous system (ANS) may contribute to AF, leading to increased interest in neuromodulation techniques for the intrinsic cardiac ANS.
Article
Cardiac & Cardiovascular Systems
Christopher Monkhouse, Amy Wharmby, Zoe Carter, Ross Hunter, Mehul Dhinoja, Anthony Chow, Antonio Creta, Shohreh Honarbakhsh, Syed Ahsan, Michele Orini, Pier D. Lambiase
Summary: The aim of this study was to evaluate the impact of the SMART Pass (TM) algorithm on inappropriate therapy (IT) in subcutaneous internal cardiac defibrillator (S-ICD) and to explore the association between SP deactivation and IT. The results showed that SP deactivation was significantly associated with an increased risk of IT, and changing the sensing vector was successful in preventing IT.
Letter
Cardiac & Cardiovascular Systems
Jaffar Al-Sheikhli, James Winter, Ivo Roca Luque, Pier D. Lambiase, Michele Orini, Andreu Porta-Sanchez, Tarvinder Dhanjal
Article
Cardiac & Cardiovascular Systems
Shohreh Honarbakhsh, Claire A. Martin, Gurpreet Dhillon, Mark Gallagher, Manav Sohal, Anthony Chow, Syed Ahsan, Hakam Abbass, Sarah Whittaker-Axon, Pier D. Lambiase, Mark J. Davies, Matthew Ginks, Ross J. Hunter
Summary: This study evaluated the effectiveness and safety of high power short duration (HPSD) ablation for atrial fibrillation ablation. The results showed that HPSD ablation can effectively achieve pulmonary vein isolation and has advantages in procedural time, ablation time, and reconnection rate.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, Aaron Isaacs, Andrew R. Harper, Julia Ramirez, Sophie Garnier, Stefan van Duijvenboden, Antoine R. Baldassari, Maria Pina Concas, ThuyVy Duong, Luisa Foco, Jonas L. Isaksen, Hao Mei, Raymond Noordam, Casia Nursyifa, Anne Richmond, Meddly L. Santolalla, Colleen M. Sitlani, Negin Soroush, Sebastien Theriault, Stella Trompet, Stefanie Aeschbacher, Fariba Ahmadizar, Alvaro Alonso, Jennifer A. Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Antonio De Luca, Jean-Francois Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Christopher Grace, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Rebecca D. Jackson, Jan A. Kors, Maria Fernanda Lima-Costa, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David J. Porteous, Peter P. Pramstaller, Alexander P. Reiner, Lorenz Risch, Ulrich Schotten, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Monika Stoll, Eduardo Tarazona-Santos, Andrew Tinker, Katerina Trajanoska, Eric Villard, Helen R. Warren, Eric A. Whitsel, Kerri L. Wiggins, Dan E. Arking, Christy L. Avery, David Conen, Giorgia Girotto, Niels Grarup, Caroline Hayward, J. Wouter Jukema, Dennis O. Mook-Kanamori, Morten Salling Olesen, Sandosh Padmanabhan, Bruce M. Psaty, Cristian Pattaro, Antonio Luiz P. Ribeiro, Jerome I. Rotter, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James G. Wilson, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry J. Lin, James F. Wilson, Jrgen K. Kanters, Nona Sotoodehnia, Borbala Mifsud, Pier D. Lambiase, Larisa G. Tereshchenko, Patricia B. Munroe
Summary: Using multi-ancestry genome-wide association studies, this research identified 61 loci related to spatial QRS-T angle and 11 loci related to frontal QRS-T angle. These loci also showed shared genetic influences with classical ECG traits and were associated with cardiovascular diseases. The findings provide insights into the biology of QRS-T angles and their relationships with cardiovascular traits and diseases, which can inform future research and risk prediction.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
George Joy, Christopher I. Kelly, Matthew Webber, Iain Pierce, Irvin Teh, Louise Mcgrath, Paula Velazquez, Rebecca K. Hughes, Huafrin Kotwal, Arka Das, Fiona Chan, Athanasios Bakalakos, Massimiliano Lorenzini, Konstantinos Savvatis, Saidi A. Mohiddin, Peter W. Macfarlane, Michele Orini, Charlotte Manisty, Peter Kellman, Rhodri H. Davies, Pier D. Lambiase, Christopher Nguyen, Jurgen E. Schneider, Maite Tome, Gabriella Captur, Erica Dall'Armellina, James C. Moon, Luis R. Lopes
Summary: In patients with hypertrophic cardiomyopathy, alterations in myocardial microstructure and microvascular disease have been found to occur early in the disease process. These changes serve as potential early phenotype biomarkers for disease detection and management.
Article
Cardiac & Cardiovascular Systems
Mark J. Specterman, Qadeer Aziz, Yiwen Li, Naomi A. Anderson, Leona Ojake, Keat-Eng Ng, Alison M. Thomas, Malcolm C. Finlay, Richard J. Schilling, Pier D. Lambiase, Andrew Tinker
Summary: This study investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of the K-ATP pore-forming subunits. The results showed that K-ATP blockade or absence resulted in atrial electrophysiological modifications at the cellular and tissue level. Furthermore, the global knockout of Kir6.2 prevented hypoxia-induced atrial path length shortening and arrhythmogenicity, suggesting a potential translational approach for treating ischemically driven atrial arrhythmia.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Pier D. Lambiase
Article
Cardiac & Cardiovascular Systems
Gurpreet Dhillon, Shohreh Honarbakhsh, Hakam Abbas, Peter Waddingham, Adam S. Dennis, Nikhil Ahluwalia, Malcolm Finlay, Afzal Sohaib, Sophie Welch, Holly Daw, Simon Sporton, Anthony Chow, Mark J. Earley, Pier D. Lambiase, Ross J. Hunter
Summary: This study evaluated the clinical outcomes and response to ablation of potential drivers in patients with recurrent persistent AF following pulmonary vein isolation (PVI). The study found that ECGI-guided ablation caused an acute response in a majority of patients and had reasonable long-term outcomes.
Article
Cardiac & Cardiovascular Systems
Charles Butcher, Caroline Roney, Amy Wharmby, Nikhil Ahluwalia, Anthony Chow, Pier D. Lambiase, Ross J. Hunter, Shohreh Honarbakhsh
Summary: This study evaluated different methods for assessing atrial voltage and their accuracy in identifying pulmonary vein reconnection sites (PVRSs) in atrial fibrillation (AF). The results showed that omnipoar voltage atrial fibrillation (OV AF) maps improve voltage assessment by overcoming the impact of wavefront collision and fractionation, leading to improved accuracy.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)