NM101 Phase III study of NE3107 in Alzheimer’s disease: rationale, design and therapeutic modulation of neuroinflammation and insulin resistance

Inflammation Spreading: Negative Spiral Linking Systemic Inflammatory Disorders and Alzheimer’s Disease

(2021) Junjun Ni et al.   Frontiers in Cellular Neuroscience

Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease

(2021) Michael J. Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

(2020) Christian Hölscher   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease

(2020) Jong Youl Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Insulin in Neurotrauma and Neurodegeneration: A Review

(2020) Michael Shaughness et al.   Frontiers in Neuroscience

HDL Proteome and Alzheimer’s Disease: Evidence of a Link

(2020) Judit Marsillach et al.   Antioxidants

Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment

(2019) Claudia Cristiano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurometabolic Evidence Supporting the Hypothesis of Increased Incidence of Type 3 Diabetes Mellitus in the 21st Century

(2019) Anna Rorbach-Dolata et al.   Biomed Research International

Diabetic Theory in Anti-Alzheimer’s Drug Research and Development. Part 1: Therapeutic Potential of Antidiabetic Agents

(2019) Agnieszka Jankowska et al.   CURRENT MEDICINAL CHEMISTRY

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study

(2018) Wei-Ju Lee et al.   Scientific Reports

The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study

(2018) Ontefetse Ntlholang et al.   BRITISH JOURNAL OF NUTRITION

Complement in the pathogenesis of Alzheimer’s disease

(2017) B. Paul Morgan   Seminars in Immunopathology

Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma

(2017) Wendi S. Lambert et al.   Frontiers in Neuroscience

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

(2016) S Monteiro et al.   Translational Psychiatry

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease

(2015) Auriel A. Willette et al.   DIABETES

Amyloid β oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes

(2015) Qinghua Zhang et al.   GENE

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

(2015) Colm Cunningham et al.   Alzheimers Research & Therapy

Dipeptidyl Peptidase-4 Inhibitors Have Protective Effect on Cognitive Impairment in Aged Diabetic Patients With Mild Cognitive Impairment

(2014) M. R. Rizzo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

An Anti-Inflammatory Sterol Decreases Obesity-Related Inflammation-Induced Insulin Resistance and Metabolic Dysregulation

(2013) Chris L. Reading et al.   MEDIATORS OF INFLAMMATION

A synthetic anti-inflammatory sterol improves insulin sensitivity in insulin-resistant obese impaired glucose tolerance subjects

(2013) Christopher L. Reading et al.   Obesity

Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition

(2012) M. R. Rizzo et al.   DIABETES CARE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome

(2012) Christopher L. Reading et al.   PLoS One

Central Obesity in the Elderly is Related to Late-onset Alzheimer Disease

(2011) José A. Luchsinger et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome

(2011) Clarence N. Ahlem et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Adding Delayed Recall to the Alzheimer Disease Assessment Scale is Useful in Studies of Mild Cognitive Impairment But Not Alzheimer Disease

(2010) Mary Sano et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats

(2010) Min Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amelioration of Glucose Intolerance by the Synthetic Androstene HE3286: Link to Inflammatory Pathways

(2010) T. Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Potential Role for 5-Androstene-3β,7β,17β-triol in Obesity and Metabolic Syndrome

(2010) Dominick L. Auci et al.   Obesity

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation