Mitochondrial DNA repair: a novel therapeutic target for heart failure

Mitochondrial genome maintenance in health and disease

(2014) William C. Copeland et al.   DNA REPAIR

To be or not to be a nucleoid protein: A comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins

(2013) Fenna Hensen et al.   BIOCHIMIE

Replicating animal mitochondrial DNA

(2013) Emily A. McKinney et al.   GENETICS AND MOLECULAR BIOLOGY

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

Mechanism of Homologous Recombination and Implications for Aging-Related Deletions in Mitochondrial DNA

(2013) X. J. Chen   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Overexpression of Twinkle Helicase Ameliorates the Progression of Cardiac Fibrosis and Heart Failure in Pressure Overload Model in Mice

(2013) Atsushi Tanaka et al.   PLoS One

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

(2013) J. L. O. Pohjoismaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical and Molecular Features of POLG-Related Mitochondrial Disease

(2013) J. D. Stumpf et al.   Cold Spring Harbor Perspectives in Biology

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

(2012) Deborah L. Croteau et al.   AGING CELL

Mitochondrial DNA damage and its consequences for mitochondrial gene expression

(2012) Susan D. Cline   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

(2012) Amy M. Furda et al.   DNA REPAIR

Human Mitochondrial DNA Helicase TWINKLE Is Both an Unwinding and Annealing Helicase

(2012) Doyel Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

(2012) S. De et al.   JOURNAL OF CELL SCIENCE

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

(2012) P-L Chen et al.   ONCOGENE

Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction

(2011) Jianxun Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial DNA nucleoid structure

(2011) Daniel F. Bogenhagen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The interface of transcription and DNA replication in the mitochondria

(2011) Rajesh Kasiviswanathan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA

(2011) Jaakko L. O. Pohjoismäki et al.   BIOESSAYS

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome

(2011) Anne W. Tann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of persistent strand breaks in the mitochondrial genome

(2011) Peter Sykora et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

(2010) David Svilar et al.   ANTIOXIDANTS & REDOX SIGNALING

The human mitochondrial replication fork in health and disease

(2010) Sjoerd Wanrooij et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers

(2010) Siôn L. Williams et al.   Cell Metabolism

Ultrasensitive Simultaneous Quantification of 1,N2-Etheno-2′-deoxyguanosine and 1,N2-Propano-2′-deoxyguanosine in DNA by an Online Liquid Chromatography−Electrospray Tandem Mass Spectrometry Assay

(2010) Camila C. M. Garcia et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts

(2010) Georgios Karamanlidis et al.   CIRCULATION RESEARCH

The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number

(2010) Senyene E. Hunter et al.   METHODS

The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders

(2010) Bruce H. Cohen et al.   METHODS

Developmental and Pathological Changes in the Human Cardiac Muscle Mitochondrial DNA Organization, Replication and Copy Number

(2010) Jaakko L. O. Pohjoismäki et al.   PLoS One

Control by Circulating Factors of Mitochondrial Function and Transcription Cascade in Heart Failure

(2009) Anne Garnier et al.   Circulation-Heart Failure

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

(2009) S. R. Bacman et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

Structure–function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia

(2008) Teresa Holmlund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

(2008) Muralidhar L Hegde et al.   CELL RESEARCH

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

(2008) Mansour Akbari et al.   DNA REPAIR

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

(2008) Steffi Goffart et al.   HUMAN MOLECULAR GENETICS

Role of SUV3 Helicase in Maintaining Mitochondrial Homeostasis in Human Cells

(2008) Lily Khidr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

(2008) Bartosz Szczesny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA repair in aging and disease

(2008) Nadiya M. Druzhyna et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL