Review
Microbiology
Ana Espinel-Ingroff, Emilia Canton, Javier Peman
Summary: Fungal diseases and antifungal resistance are on the rise, including those caused by rare or emerging species. Limited data is available for the susceptibility of less common Candida species, but epidemiological cutoff values (ECVs/ECOFFs) have been established to identify non-wild type isolates with known resistance mechanisms. Additional percentages of non-wild type isolates, especially for non-prevalent species, have been reported by analyzing MIC distributions in the literature.
Article
Microbiology
Sarah R. Beattie, Taiwo Esan, Robert Zarnowski, Emily Eix, Jeniel E. Nett, David R. Andes, Timothy Hagen, Damian J. Krysan
Summary: New antifungal therapies are needed for various fungal infections, including biofilms and drug-resistant strains. A novel keto-alkyl-pyridinium scaffold has been identified with broad spectrum activity against medically important fungi. This class of molecules shows potential for non-systemic applications.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Rabina Kumpakha, Donna M. Gordon
Summary: In this study, the researchers demonstrated the efficacy of occidiofungin against biofilm development of Candida albicans and Candida tropicalis, including inhibiting cell dispersal. The results suggest that occidiofungin has strong antibiofilm activity and potential as a therapeutic for Candida infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Milena Radunovic, Milena Barac, Jovana Kuzmanovic Pficer, Dusan Pavlica, Aleksandar Jovanovic, Ana Pucar, Sanja Petrovic
Summary: The aim of this study was to compare the antifungal susceptibility of Candida isolated from the tongue and subgingival biofilm. The results showed that both tongue and subgingival isolates were susceptible to amphotericin B. Tongue isolates were more susceptible to fluconazole, while subgingival isolates showed lower susceptibility to itraconazole. The study also found a correlation between the susceptibility of C. albicans to antifungals and oral hygiene and moderate periodontal destruction.
Article
Infectious Diseases
Anna Dudakova, Claudia Blei, Uwe Gross, Marco H. Schulze
Summary: This study analyzes the impact of bedside antifungal stewardship (AFS) on clinical management and prognosis of patients with candidemia at a university hospital in Germany. The results show that bedside AFS significantly improves adherence to recommendations for antifungal treatment and follow-up in patients with Candida fungemia. However, improving the prognosis of patients with candidemia remains a huge challenge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Georgiana Negru, Laure Kamus, Elena Bicu, Sergiu Shova, Boualem Sendid, Faustine Dubar, Alina Ghinet
Summary: The reaction between benzylidenemalononitriles and phenylhydrazines in refluxing ethanol did not lead to pyrazole derivatives, but instead produced hydrazones, whose structure was confirmed by X-ray analysis. The newly synthesized hydrazones showed promising antifungal activity against Candida spp., with five compounds demonstrating selective antifungal activity with MIC99 values ranging from 16 to 32 μg/mL.
Article
Microbiology
Katura Metzner, Matthew J. O'Meara, Benjamin Halligan, Jesse W. Wotring, Jonathan Z. Sexton, Teresa R. O'Meara
Summary: Fungal pathogens like Candida albicans can cause devastating human disease, but there is high resistance to antifungal therapies. Targeting virulence factors is a new approach to antimicrobial development, and we identified NSC 697923 as a compound that blocks the hyphal transition in C. albicans by targeting eIF3.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Henry W. Nabeta, Joseph C. Kouokam, Amanda B. Lasnik, Joshua L. Fuqua, Kenneth E. Palmer
Summary: This study demonstrates the novel antifungal activity of Q-Griffithsin (Q-GRFT) against various Candida strains by binding to alpha-mannan in the cell wall, disrupting cell wall integrity, and inducing ROS formation leading to cell death. Q-GRFT also inhibits the growth of other Candida species and shows potential as a drug candidate for the prevention and treatment of fungal infections.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Lynn Miesel, Melanie T. Cushion, Alan Ashbaugh, Santiago R. Lopez, Voon Ong
Summary: Rezafungin, a novel echinocandin, has shown efficacy against Candida, Aspergillus, and Pneumocystis in prophylactic studies. By reducing fungal burden and preventing infection, it has the potential to be a single-agent prophylaxis against invasive fungal diseases caused by these pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Jie Tu, Na Liu, Yahui Huang, Wanzhen Yang, Chunquan Sheng
Summary: Candida auris is a major global threat to human health due to its strong drug resistance. This review provides a comprehensive overview of current strategies, drug candidates, and lead compounds for the treatment of C. auris. The resistance profiles and mechanisms are summarized, and the structures and activities of clinical candidates, drug combinations, antifungal chemosensitizers, repositioned drugs, new targets, and new types of compounds are discussed in detail. The review also offers perspectives for guiding future research in this field.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biotechnology & Applied Microbiology
Payal Gupta, Hrishikesh Gupta, Krishna Mohan Poluri
Summary: The research evaluated the antifungal activity of geraniol against Candida glabrata biofilm, discovering multiple mechanisms including biofilm eradication, cellular pathway interference, and induction of apoptosis. These findings strengthen the candidacy of geraniol as a novel antifungal therapeutic.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Infectious Diseases
Anna Esposito, Antonella Migliaccio, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna, Eliana De Gregorio
Summary: The glucocorticoid PYED-1 showed weak antifungal activity against five major Candida species but exhibited good anti-biofilm activity. It also inhibited germ tube and hyphae formation of C. albicans and reduced adhesion of C. albicans to abiotic surfaces by up to 30%.
Article
Nanoscience & Nanotechnology
Sebastian Schaefer, Thi Thu Phuong Pham, Sascha Brunke, Bernhard Hube, Kenward Jung, Megan Denise Lenardon, Cyrille Boyer
Summary: Research has been conducted on the effect of degree of polymerization and hydrophobic functionalities on the antifungal activity of synthetic polyacrylamides. Short copolymers with a calculated log P of around 1.5 have shown optimal activity against major human fungal pathogens, with limited toxicity to mammalian host cells. Selected copolymers have shown potential as novel antifungal compounds, outperforming commercial antifungal drugs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Microbiology
Monica Ganan, Silje B. Lorentzen, Peter Gaustad, Morten Sorlie
Summary: C32 demonstrates concentration-dependent inhibition of Candida biofilms, reducing viable cells and metabolic activity, while also inhibiting new biofilm formation. When used in combination with fluconazole or miconazole, a synergistic effect on biofilm reduction is observed, indicating the potential of C32 as an alternative therapeutic agent to combat antifungal resistance.
Article
Infectious Diseases
Clarice Elvira Saggin Sabadin, Soraia Lima Lopes, Olga Fischmamm Gompertz, Gilglecia Novaes Pereira Santana, Analy Salles de Azevedo Melo, Lilian Rigo, Daniel Archimedes Da Matta, Dulce Aparecida Barbosa
Summary: This study investigated oral colonization of Candida species and their susceptibility to antifungals in liver transplant patients. Results showed stable yeast species colonization in some patients over 6 months, but substitution in others. The study highlights the importance of monitoring antifungal resistant strains.
Article
Cardiac & Cardiovascular Systems
Gabriela Lima de Melo Ghisi, Andree-Anne Hebert, Paul Oh, Tracey Colella, Crystal Aultman, Carolina Carvalho, Rajni Nijhawan, Marie-Kristelle Ross, Sherry L. Grace
Summary: This study aimed to co-design women-focused cardiac rehabilitation (CR) education to meet their specific needs. Through literature review, needs assessment, and content development, the research team created open-access educational resources including videos and slide decks. These resources will be used to support women in reducing their risk of cardiovascular sequelae.
Article
Cardiac & Cardiovascular Systems
Hannah Spielmann, Wolfgang Albert, Sandra Semmig-Koenze, Volker Lauenroth, Christine Spitz-Koeberich, Paulina Staus, Katharina Tigges-Limmer, Christiane Kugler, S. E. L. M. A. Study SELMA Study Grp
Summary: This study investigated the construct of psychosocial adjustment and the role of social support in patients with durable VAD support. The results showed that the majority of the participants reported high levels of perceived social support and good psychosocial adjustment. Higher levels of perceived social support were associated with lower levels of anxiety and depression, and higher levels of quality of life.
Article
Cardiac & Cardiovascular Systems
Tania T. Von Visger, Ji Won Shin, Mary Beth Happ
Summary: This study explores the perspectives of Urban Zen Integrative Therapy interventionists on the delivery of the therapy, aiming to gain a deeper understanding of subjective variables that may influence intervention fidelity. The results reveal several key themes related to adherence to the intervention delivery, such as balancing between tailoring and standardization, challenges faced during delivery, the need for teamwork, and clients' application of the therapy.
Review
Cardiac & Cardiovascular Systems
Dejina Thapa, Sek Ying Chair, Mei Sin Chong, Rishi Ram Poudel, Tenaw Gualau Melesse, Kai Chow Choi, Hon Lon Tam
Summary: The ventilator bundle has been found to effectively reduce the incidence of ventilator-associated pneumonia and improve related outcomes. However, caution should be exercised in interpreting these findings due to the low-to-moderate certainty of evidence and high heterogeneity.
Article
Cardiac & Cardiovascular Systems
Jianxiong Lai, Bin Fang, Lirong Luo, Wenjie Xie, Yuanhui Xu, Jian Li
Summary: This study used two-sample bidirectional mendelian randomization to explore the causal link between asthma and inflammatory bowel disease. The researchers found a negative correlation between asthma and Crohn's disease. However, further research is needed to confirm this finding.
Article
Cardiac & Cardiovascular Systems
Eriadina Alves Lima, Gezabell Rodrigues, Beatriz Carneiro Mota, Shamyr Sulyvan Castro, Rafael Barreto Mesquita, Camila Ferreira Leite
Summary: This study investigated the components of the International Classification of Functioning, Disability and Health (ICF) reflected in the assessment instruments used in cardiac rehabilitation for individuals with heart failure (HF). The results showed that body function was the most frequently detected component, but none of the instruments covered all aspects of the ICF. The Minnesota Living with Heart Failure Questionnaire (MLHFQ) demonstrated the most comprehensive coverage of ICF components.
Review
Cardiac & Cardiovascular Systems
Baolu Yang, Leyi Gao, Zhaohui Tong
Summary: The use of sedative and analgesic medications during non-invasive ventilation can reduce the risk of tracheal intubation and delirium in patients with acute respiratory failure. Among the different medications, dexmedetomidine showed better clinical outcomes, especially when closely monitoring the patients' vital signs.
Article
Cardiac & Cardiovascular Systems
Liu Huang, Mengtao Song, Ling Wang, Qiran Zhang, Xiao Liu, Chunfeng Cai
Summary: This study examines the reliability and validity of the Chinese Interoceptive Awareness Questionnaire (C-IAQ) for Chinese cardiovascular disease (CVD) patients. The results indicate that the C-IAQ has favorable psychometric features and can be used to measure the interoceptive awareness of CVD patients.
Review
Cardiac & Cardiovascular Systems
Qiuxia Zhang, Khuan Lee, Zawiah Mansor, Iskasymar Ismail, Yi Guo, Qiao Xiao, Poh Ying Lim
Summary: This study conducted a systematic review to understand the effect of rapid response teams (RRT) on patient outcomes. The results showed that, despite variation in context and intervention type, most studies demonstrated that RRT positively impacts patient outcomes.
Article
Cardiac & Cardiovascular Systems
Sikandar H. Khan, Anthony J. Perkins, Samreen Jawaid, Sophia Wang, Heidi Lindroth, Rebecca E. Schmitt, Jason Doles, Jason D. True, Sujuan Gao, Gideon A. Caplan, Homer L. Twigg III, Kenneth Kesler, Babar A. Khan
Summary: This study aimed to identify protein pathways associated with delirium post-esophagectomy. The findings revealed that coagulation factor IX and mannosyl-oligosaccharide 1,2-alpha-mannosidase were associated with delirium, while complement C2 and mannosyl-oligosaccharide 1,2-alpha-mannosidase were associated with delirium severity.
Review
Cardiac & Cardiovascular Systems
Hua Li, Tao Dong, Jinling Luan
Summary: Fluticasone propionate and salmeterol (FSC) are viable options for step-up treatment in asthmatic children, as they can reduce the incidence of asthma exacerbations and improve lung function. FSC treatment for more than 12 weeks shows a greater likelihood of reducing asthma exacerbations and decreasing the use of albuterol. There were no significant differences in drug-related adverse events between FSC and fluticasone propionate (FP) alone.
Article
Cardiac & Cardiovascular Systems
Harrison Krebs, Kimberly Crutcher, Yan Su, Marilyn A. Prasun
Summary: During the COVID pandemic, patients experienced increased depression and poorer quality of life. However, significant improvements were observed in all outcomes following completion of Cardiac Rehabilitation (CR).
Article
Cardiac & Cardiovascular Systems
Hong-Lin Wu, Si-Jia Zhou, Xiu-Hua Chen, Hua Cao, Yi-Rong Zheng, Qiang Chen
Summary: This study aimed to evaluate the value of LUS score at VA-ECMO withdrawal in neonatal ARDS patients. The results showed that LUS score significantly improved during VA-ECMO treatment and could be used to evaluate various lung diagnostic signs. Additionally, LUS score was positively correlated with ECMO blood flow and could predict ECMO weaning success.
Article
Cardiac & Cardiovascular Systems
Lingyu Lin, Yanchun Peng, Xizhen Huang, Sailan Li, Liangwan Chen, Yanjuan Lin
Summary: This study aimed to investigate the effects of family intervention on the incidence of postoperative delirium (POD) and ICU prognoses of patients undergoing cardiac valve surgery. The results showed that family intervention could reduce the incidence of POD, shorten ICU stays, reduce the incidence of anxiety and depression in family caregivers, and improve their satisfaction. Therefore, family intervention is of significant importance for patients undergoing cardiac valve surgery.
