Article
Engineering, Biomedical
Elif Ilhan, Songul Ulag, Ali Sahin, Betul Karademir Yilmaz, Nazmi Ekren, Osman Kilic, Mustafa Sengor, Deepak M. Kalaskar, Faik Nuzhet Oktar, Oguzhan Gunduz
Summary: In this research, 3D printed patches for treating tympanic membrane perforations were produced using a combination of PLA, Chitosan, and Sodium Alginate. By adding different ratios of Chitosan and Sodium Alginate to PLA, the biocompatibility of the produced scaffolds was increased. Among all concentrations tested, groups containing 3 wt% Chitosan and 3 wt% Sodium Alginate showed significantly superior printing quality. This study suggests that PLA/Chitosan and PLA/Sodium Alginate 3D printed artificial patches have the potential to provide tissue engineering solutions for repairing tympanic membrane perforations in individuals with hearing loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Abbas Shafiee, Amanda S. Cavalcanti, Navid T. Saidy, Dominik Schneidereit, Oliver Friedrich, Akhilandeshwari Ravichandran, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher
Summary: The biomimetically designed mPCL dressings, combined with human cell seeding, promote wound healing, reduce scar formation, and enhance skin regeneration.
Article
Otorhinolaryngology
Zifei Yang, Xiaoyun Chen, Fan Ye, Yideng Huang, Xianmin Wu, Cong Wu
Summary: The study indicates that the customized 3D-printed guiding template can improve closure rate and decrease operation time in endoscopic type I tympanoplasty. The improvements in hearing outcomes were similar for both groups.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Alexandra Cernencu, Andreea Dinu, Izabela C. Stancu, Adriana Lungu, Horia Iovu
Summary: This review focuses on the application of nanoengineered hydrogels in 3D printing of biomimetic constructs, with particular emphasis on the impact of the spatial distribution of reinforcing agents (0D, 1D, 2D). The relationship between relevant length scales and size effects that influence the final properties of hydrogels for regenerative medicine is systematically analyzed, highlighting the use of naturally-derived nanostructured inks.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Review
Engineering, Biomedical
Bharti Bisht, Ashley Hope, Anubhab Mukherjee, Manash K. Paul
Summary: The demand for bone grafts is high and complex, with traditional substitutes facing limitations, but the development of 3D printing technology is creating optimism for repairing bone trauma and defects in the future.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Elisabetta Rosellini, Maria Grazia Cascone, Lorenzo Guidi, Dirk W. Schubert, Judith A. Roether, Aldo R. Boccaccini
Summary: Myocardial infarction is a major cause of mortality and morbidity worldwide. The development of functional cardiac tissue through cardiac tissue engineering is being explored as an alternative treatment option. Current research focuses on using three-dimensional printing and natural biomaterials to fabricate biomimetic cardiac patches. Functionalization strategies are important for enhancing the bioactivity and mimicry of the patches.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Shivesh Anand, Serena Danti, Lorenzo Moroni, Carlos Mota
Summary: It is estimated that by 2050 one in every ten people will be suffering from disabling hearing loss. Perforated tympanic membranes (TMs) are the most common injury to the human ear, resulting in a partial or complete hearing loss due to inept sound conduction. Tissue engineering approaches, including TM repair and reconstruction, have been developed for TM regeneration.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Harshavardhan Budharaju, Shruthy Suresh, Muthu Parkkavi Sekar, Brigita De Vega, Swaminathan Sethuraman, Dhakshinamoorthy Sundaramurthi, Deepak M. Kalaskar
Summary: Ceramic bone implants have potential properties ideal for long-term implantation applications, and they have advantages including biocompatibility, low cost, and the ability to be made into various shapes. Bone transplantation is the second largest transplantation surgery globally, indicating hope for potential treatment options for bone diseases.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Suihong Liu, Liguo Sun, Haiguang Zhang, Qingxi Hu, Yahao Wang, Murugan Ramalingam
Summary: This study aims to design and fabricate mechanically-tunable nerve conduits with biomimetic structural features of the human nerve, and the results confirm the potential of the combinatorial approach in fabricating mechanically-tunable triple-layered conduits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, Research & Experimental
Iman Ghanad, Marc D. Polanik, Danielle R. Trakimas, Renata M. Knoll, Melissa Castillo-Bustamante, Nicole L. Black, Elliott D. Kozin, Aaron K. Remenschneider
Summary: Most studies evaluate nonautologous materials in acute or traumatic tympanic membrane perforations, with few rigorously reporting auditory outcomes. Porcine small-intestinal submucosa and basic fibroblast growth factor show potential for chronic perforation closure based on available data. Future research should focus on reporting closure rates and auditory outcomes in perforations lasting more than 8 weeks.
Review
Biochemistry & Molecular Biology
Samira Malekmohammadi, Negar Sedghi Aminabad, Amin Sabzi, Amir Zarebkohan, Mehdi Razavi, Massoud Vosough, Mahdi Bodaghi, Hajar Maleki
Summary: Smart/stimuli-responsive hydrogels have diverse applications in the biomedical field, with the ability to change behavior in response to external stimuli; technologies like 4D bioprinting have expanded the possibilities of using smart hydrogels in various biomedical applications, driving innovation and development in the field.
Article
Chemistry, Multidisciplinary
Zeyu Luo, Liming Lian, Thiago Stocco, Jie Guo, Xuan Mei, Ling Cai, Syed Muntazir Andrabi, Yajuan Su, Guosheng Tang, Hossein Ravanbakhsh, Wanlu Li, Mian Wang, Xiao Kuang, Carlos Ezio Garciamendez-Mijares, Di Wang, Zongliang Wang, Junlong Liao, Maobin Xie, Jingwei Xie, Heemin Kang, Anderson Oliveira Lobo, Zongke Zhou, Yu Shrike Zhang
Summary: A cryo(bio)printing-based method is developed to fabricate shelf-ready, storable modules for scalable tissue assembly. The method involves assembling cryo(bio)printed modular scaffolds in their frozen state and subsequently bonding them together into an integral piece during the melting and photocrosslinking processes. This method overcomes the height limitation of cryo(bio)printing and allows the generation of tissue constructs of same or dissimilar materials for more precise treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Zhou Jian, Tian Zhuang, Tian Qinyu, Peng Liqing, Li Kun, Luo Xujiang, Wang Diaodiao, Yang Zhen, Jiang Shuangpeng, Sui Xiang, Huang Jingxiang, Liu Shuyun, Hao Libo, Tang Peifu, Yao Qi, Guo Quany
Summary: By optimizing the preparation of meniscus-derived bioink and utilizing a custom 3D bioprinting system, a biomimetic meniscal scaffold with optimal features in terms of morphology and components was successfully created. Comprehensive evaluations were conducted on cell viability, mechanics, biodegradation, and tissue formation to ensure the scaffold's feasibility and functionality for application in tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Shenqiang Wang, Sheng Zhao, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: 3D printing technology has great potential in the field of tissue engineering, allowing the fabrication of biomimetic tissue structures for personalized therapy of various diseases. This review introduces the recently developed 3D printing techniques and summarizes their applications in cartilage, bone, and osteochondral tissue regeneration.
Review
Chemistry, Multidisciplinary
Zhen Wang, Wasim Kapadia, Cuidi Li, Feng Lin, Ruben F. Pereira, Pedro L. Granja, Bruno Sarmento, Wenguo Cui
Summary: The human body is composed of four basic tissue types: epithelial, connective, muscular, and nervous tissues, each consisting of cells with similar functions. Three-dimensional bioprinting, based on histological categories, is a versatile technology that can form functional organ structures simply. This technology shows remarkable regenerative power and novel breakthroughs in specific tissues like muscle and nerve tissues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Otorhinolaryngology
Ashley L. Miller, Andrew J. Holcomb, Anuraag S. Parikh, Julianne M. Richards, Vinay K. Rathi, Jeremy W. Goldfarb, Aaron K. Remenschneider, Regan W. Bergmark, Donald J. Annino, Laura A. Goguen, Eleni M. Rettig, Daniel G. Deschler, Kevin S. Emerick, Derrick T. Lin, Jeremy D. Richmon, Chiao-Li Chan, Lillian C. Min, Ravindra Uppaluri, Mark A. Varvares
Summary: The study demonstrated the feasibility of using the VESPA tool to assess the functional status of patients undergoing major head and neck surgery. Patients with low functional status identified by VESPA were found to be at risk for delayed discharge and complex discharge planning. These patients may benefit from enhanced preoperative counseling and more comprehensive discharge preparation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Kristine Elisabeth Eberhard, Salwa Fatima Masud, Inge M. Knudson, Keshinisuthan Kirubalingam, Hamza Khalid, Aaron K. Remenschneider, Hideko Heidi Nakajima
Summary: The study found that ears with temporalis fascia grafts had lower absorbance at mid to high frequencies postoperatively, leading to poor sound transmission. Additionally, the mechanical impedance of these ears showed deeper and sharper resonant notches compared to normal ears, indicating lower resistance in the fascia grafts. Improving the coupling between the graft and the malleus could enhance sound transmission for tympanic membrane reconstructions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Review
Medical Laboratory Technology
Murat Tekguc, Ronald C. Van Gaal, Sebastien G. M. Uzel, Navin Gupta, Leonardov V. Riella, Jennifer A. Lewis, Ryuji Morizane
Summary: The kidney is an important organ that plays a crucial role in regulating bodily fluid and electrolyte balance. Traditional research methods are unable to fully replicate complex human kidney diseases. However, advancements in directed differentiation of induced pluripotent stem cells and biofabrication techniques have allowed the generation of patient-specific 3D kidney organoids and the construction of vascularized kidney tissues. Gene editing technology can also be used to minimize immune rejection in kidney transplant recipients.
TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Benito Roman-Manso, Robert D. Weeks, Ryan L. Truby, Jennifer A. Lewis
Summary: Embedded 3D printing combined with microwave-activated curing is used to generate architected ceramics with spatially controlled composition in freeform shapes. This integrated manufacturing method opens new avenues for the design and fabrication of complex ceramic architectures with programmed composition, density, and form for myriad applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Robert D. D. Weeks, Ryan L. L. Truby, Sebastien G. M. Uzel, Jennifer A. A. Lewis
Summary: Recent advancements in computational design and 3D printing technology have allowed for the fabrication of polymer lattices that have a high strength-to-weight ratio and tailored mechanics. However, limitations with most commercial 3D printing platforms have only allowed for the construction of monolithic 3D lattices. This study demonstrates the use of embedded three-dimensional (EMB3D) printing to create multi-material polymer lattices, enabling the fabrication of a wide range of periodic and stochastic lattices with tailored mechanical responses by printing multiple materials with different mechanical properties.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Natalie M. Larson, Jochen Mueller, Alex Chortos, Zoey S. Davidson, David R. Clarke, Jennifer A. Lewis
Summary: This article presents a rotational multimaterial 3D printing (RM-3DP) platform that allows subvoxel control over the local orientation of azimuthally heterogeneous architected filaments. By continuously rotating a multimaterial nozzle with a controlled ratio of angular-to-translational velocity, helical filaments with programmable helix angle, layer thickness, and interfacial area between different materials can be created. Functional artificial muscles and hierarchical lattices composed of architected helical struts have been successfully fabricated using this method.
Article
Materials Science, Multidisciplinary
Bradley Duncan, Robert D. Weeks, Benjamin Barclay, Devon Beck, Patrick Bluem, Roberto Rojas, Maxwell Plaut, John Russo, Sebastien G. M. Uzel, Jennifer A. Lewis, Theodore Fedynyshyn
Summary: In this study, low-loss graded dielectric materials were successfully designed and printed using active mixing of nanocomposite inks. This method enables the rapid fabrication of high-performance RF devices with locally tunable dielectric properties.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Cell Biology
Rolando Carrisoza-Gaytan, Katharina T. Kroll, Ken Hiratsuka, Navin R. Gupta, Ryuji Morizane, Jennifer A. Lewis, Lisa M. Satlin
Summary: Kidney organoids cultured with flow exhibit more mature podocytes and tubules compared to static controls. However, their physiological function needs further investigation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Aaron K. Remenschneider, Jeffrey Tao Cheng, Barbara S. Herrmann, John J. Rosowski
Summary: This study compares the performance of standard and non-standard bone conduction transducers, and finds that the Tascam transducer has a wider dynamic extended high frequency range and stronger output force above 8 kHz, while the AS400 transducer behaves more like an air conduction earphone.
Article
Audiology & Speech-Language Pathology
Anne Wolff, Sabina Storbjerg Houmoller, Li-Tang Tsai, Dan Dupont Hougaard, Michael Gaihede, Dorte Hammershoi, Jesper Hvass Schmidt
Summary: This study investigated the effect of HA intervention on long-term HRQoL changes in first-time and experienced HA users using the 15D questionnaire. The results showed significant improvements in hearing-related QoL for both groups at two-month follow-up, which sustained at long-term follow-up. However, the total 15D scores decreased significantly at long-term follow-up. Self-reported hearing abilities, word recognition scores, and HA use time were positively correlated to increased 15D scores.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Auden P. Balouch, Karen Bekhazi, Hannah E. Durkee, Rebecca M. Farrar, Mealaktey Sok, Douglas H. Keefe, Aaron K. Remenschneider, Nicholas J. Horton, Susan E. Voss
Summary: Geometry of the ear canal is important for understanding sound flow, but measurements of its geometry are lacking. This study developed methods to measure ear canal geometry using CT images and found that older adults have larger canal areas than previously assumed. The canal areas varied systematically with age cohort, with young adults having an average area of 44 mm² and older adults having a significantly larger average area of 69 mm². The measurements of canal areas at different locations and canal length were also reported.
Article
Materials Science, Multidisciplinary
Connor A. Verheyen, Sebastien G. M. Uzel, Armand Kurum, Ellen T. Roche, Jennifer A. Lewis
Summary: This study combines experimentation and computation to design granular matrices with controlled properties, allowing for potential applications in cell encapsulation, bioprinting, and tissue engineering.
Article
Audiology & Speech-Language Pathology
Katja Lund, Rodrigo Ordonez, Jens Bo Nielsen, Stine Christiansen, Sabina Storbjerg Houmoller, Jesper Hvass Schmidt, Michael Gaihede, Dorte Hammershoi
Summary: Semi-structured interviews were conducted with hearing aid users and audiologists to obtain detailed descriptions of potential value propositions. The results showed that solving hearing problems, thorough diagnosis of hearing, and tailoring hearing aid solutions to individual needs were identified as the most important value propositions for hearing aid users.
AUDIOLOGY RESEARCH
(2023)
Article
Audiology & Speech-Language Pathology
Sreeram K. Narayanan, Sabina S. Houmoller, Anne Wolff, Katja Lund, Soren Moller, Dan D. Hougaard, Michael Gaihede, Jesper H. Schmidt, Dorte Hammershoi
Summary: The retrospective reporting of users' hearing aid (HA) usage can provide insight into individualized HA usage patterns. Understanding these HA usage patterns can help to provide a tailored solution to meet the usage needs of HA users. This study aimed to understand the HA usage pattern in daily-life situations from self-reported data and to examine its relationship to self-reported outcomes. The results showed distinct usage patterns in the latent classes derived for both scenarios. The study emphasized the importance of regular use of HAs for a better self-reported HA outcome.
AUDIOLOGY RESEARCH
(2023)
Article
Otorhinolaryngology
Melissa Castillo-Bustamante, Prithwijit Roychowdhury, Dhrumi Gandhi, Elliott D. Kozin, Aaron K. Remenschneider
Summary: Scleroderma is a complex chronic progressive immune-mediated disease that causes fibrosis of the skin and internal organs, and vasculopathy. The involvement of the ear in patients with scleroderma has been poorly studied, and the etiology of hearing impairment is still unclear. In this study, we reviewed three cases of scleroderma from a temporal bone repository and found fibrosis, inflammation, and vascular changes in the middle and inner ear.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)