Article
Critical Care Medicine
Lennart Riemann, Ana Mikolic, Andrew Maas, Andreas Unterberg, Alexander Younsi
Summary: We investigated the relationship between the presence of intracranial traumatic CT pathologies and the global functional outcome one year after mTBI in young patients. The study included all patients with mTBI (GCS: 13-15) aged <=24 years from the CENTER-TBI study. The results showed that patients with CT abnormalities were less likely to achieve complete recovery 12 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Anesthesiology
T. W. Felton, W. Ahmed, I. R. White, P. van Oort, N. J. W. Rattray, C. Docherty, J. Bannard-Smith, B. Morton, I. Welters, R. McMullan, S. A. Roberts, R. Goodacre, P. M. Dark, S. J. Fowler
Summary: Ventilator-associated pneumonia is common in critically ill patients, leading to overuse of antibiotics and antimicrobial resistance. This study explores the non-invasive diagnosis of ventilator-associated pneumonia through the detection of volatile organic compounds in exhaled breath.
Article
Respiratory System
Nicholas A. Scott, Laurence Pearmain, Sean B. Knight, Oliver Brand, David J. Morgan, Christopher Jagger, Sarah Harbach, Saba Khan, Halima A. Shuwa, Miriam Franklin, Verena Kaestele, Thomas Williams, Ian Prise, Flora A. McClure, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E. Konkel, Criag Lawless, James Wilson, Alexander G. Mathioudakis, Stefan C. Stanel, Andrew Ustianowski, Gabriella Lindergard, Seema Brij, Nawar Diar Bakerly, Paul Dark, Christopher Brighting, Pilar Rivera-Ortega, Graham M. Lord, Alex Horsley, L. CIRCO, Karen Piper Hanley, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Elizabeth R. Mann
Summary: COVID-19 is associated with immune dysfunction, which may contribute to the chronic symptoms in long COVID patients. Phenotypical and functional changes in monocytes were assessed in COVID-19 patients during hospitalization and convalescence. Specific monocyte alterations were found in long COVID patients with unresolved lung injury and ongoing fatigue. These findings offer potential therapeutic opportunities for COVID-19 patients with persistent morbidity.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Correction
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gerard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras M. Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana D. Castano-Leon, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Veronique Keyser, Vincent Degos, Francesco Della Corte, Hugo Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Duliere, Ari Ercole, Erzsebet Ezer, Martin Fabricius, Kelly Foks, Shirin A. Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro Gomez, Benjamin J. Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund G. Helbok, Eirik Helseth, Jilske Huijben, Peter Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noemi Kovacs, Ana Kowark, Alfonso Lagares, Steven Laureys, Aurelie Lejeune, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Alex Manara, Hugues Marechal, Costanza Martino, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Jozsef Nyiradi, Fabrizio Ortolano, Jean-Francois Payen, Vincent Perlbarg, Paolo P. Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrod, Kari Schirmer-Mikalsen, Rico Frederik W. Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout Steyerberg, Nino Stocchetti, Nina Sundstroem, Riikka Takala, Viktoria Tamas, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils A. Valeinis, Shirley Vallance, Zoltan Vamos, Gregory Steen, T. J. M. van Dijck Jeroen, Thomas Essen, Roel Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline A. Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick Zeiler, Agate Ziverte, Tommaso V. Zoerle, Russel Gruen, Lynette Murray, Dinesh Varma, Christopher MacIsaac, Andrea Jordan
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Callum Jackson, Iain Stewart, Tatiana Plekhanova, Peter S. Cunningham, Andrew L. Hazel, Bashar Al-Sheklly, Raminder Aul, Charlotte E. Bolton, Trudie Chalder, James D. Chalmers, Nazia Chaudhuri, Annemarie B. Docherty, Gavin Donaldson, Charlotte L. Edwardson, Omer Elneima, Neil J. Greening, Neil A. Hanley, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Linzy Houchen-Wolloff, Luke S. Howard, Caroline J. Jolley, Mark G. Jones, Olivia C. Leavy, Keir E. Lewis, Nazir Lone, Michael Marks, Hamish J. C. McAuley, Melitta A. McNarry, Brijesh Patel, Karen Piper-Hanley, Krisnah Poinasamy, Betty Raman, Matthew Richardson, Pilar Rivera-Ortega, Sarah L. Rowland-Jones, Alex Rowlands, Ruth M. Saunders, Janet T. Scott, Marco Sereno, Ajay M. Shah, Aarti Shikotra, Amisha Singapuri, Stefan C. Stanel, Mathew Thorpe, Daniel G. Wootton, Thomas Yates, R. Gisli Jenkins, Sally J. Singh, William D-C Man, Christopher E. Brightling, Louise Wain, Joanna C. Porter, A. A. Roger Thompson, Alex Horsley, Philip L. Molyneaux, Rachael A. Evans, Samuel E. Jones, Martin K. Rutter, John F. Blaikley, PHOSP-COVID Study Collaborative Grp
Summary: This study investigated the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and found that sleep disturbance is associated with dyspnoea, anxiety, and muscle weakness. Targeting sleep disturbance might be beneficial in treating the post-COVID-19 condition.
LANCET RESPIRATORY MEDICINE
(2023)
Review
Medical Laboratory Technology
Reuben Roy, John Macdonald, Paul Dark, Philip Kalra, Darren Green
Summary: Recent events have highlighted the flaws in creatinine-based estimating equations for glomerular filtration. The behavior of creatinine itself, especially in acute and critical illness, contributes to these issues. There are important implications for patient treatment decisions, including drug therapies and imaging modalities. While Cystatin C has shown some success as an alternative biomarker, limitations and costs hinder its widespread use. This review explores the historical and recent evidence for glomerular filtration estimation, including options for direct measurement.
CLINICAL BIOCHEMISTRY
(2023)
Review
Health Care Sciences & Services
Andrew Metry, Abdullah Pandor, Shijie Ren, Andrea Shippam, Mark Clowes, Paul Dark, Ronan Mcmullan, Matt Stevenson
Summary: This study assessed the cost-effectiveness of treatments for coronavirus disease 2019. The results showed that these treatments were clinically effective and cost-effective, although there was some uncertainty. However, due to the evolving nature of the decision problem, the conclusions regarding the most clinical and cost-effectiveness of each intervention should be treated with caution.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Review
Critical Care Medicine
Stephen A. Spencer, Faustina Excel Adipa, Tim Baker, Ana Maria Crawford, Paul Dark, Dingase Dula, Stephen B. Gordon, David Oliver Hamilton, Dawit Kebede Huluka, Karima Khalid, Sulaiman Lakoh, Felix Limbani, Jamie Rylance, Hendry R. Sawe, Ibrahim Simiyu, Wangari Waweru-Siika, Eve Worrall, Ben Morton
Summary: There is a high burden of critical illness in low-income countries (LICs) due to various factors. Improving access to effective emergency and critical care is crucial for universal health coverage. This review examines critical care capacity building in LICs from a health systems perspective, providing recommendations for policymakers and healthcare workers.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Neill K. J. Adhikari, Madiha LOVIT-COVID Investigators, Bharath Kumar Canadian Critical Care Trials Grp, Rashan REMAP-CAP Investigators, Madiha Hashmi, Bharath Kumar Tirupakuzhi Vijayaraghavan, Rashan Haniffa, Abi Beane, Steve A. Webb, Derek C. Angus, Anthony C. Gordon, Deborah J. Cook, Gordon H. Guyatt, Lindsay R. Berry, Elizabeth Lorenzi, Paul R. Mouncey, Carly Au, Ruxandra Pinto, Julie Menard, Sheila Sprague, Marie-Helene Masse, David T. Huang, Daren K. Heyland, Alistair D. Nichol, Colin J. McArthur, Angelique de Man, Farah Al-Beidh, Djillali Annane, Matthew Anstey, Yaseen M. Arabi, Marie-Claude Battista, Scott Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Emily B. Brant, Frank M. Brunkhorst, Aidan Burrell, Meredith Buxton, Maurizio Cecconi, Allen C. Cheng, Dian Cohen, Matthew E. Cove, Andrew G. Day, Lennie P. G. Derde, Michelle A. Detry, Lise J. Estcourt, Elizabeth O. Fagbodun, Mark Fitzgerald, Herman Goossens, Cameron Green, Alisa M. Higgins, Thomas E. Hills, Nao Ichihara, Devachandran Jayakumar, Salmaan Kanji, Muhammad Nasir Khoso, Patrick R. Lawler, Roger J. Lewis, Edward Litton, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Zoe K. McQuilten, Bryan J. McVerry, Srinivas Murthy, Rachael L. Parke, Jane C. Parker, Luis Felipe Reyes, Kathryn M. Rowan, Hiroki Saito, Nawal Salahuddin, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Timo Tolppa, Tony Trapani, Alexis F. Turgeon, Anne M. Turner, Andrew A. Udy, Frank L. van de Veerdonk, Ryan Zarychanski, Francois Lamontagne
Summary: The efficacy of using vitamin C for COVID-19 treatment in critically ill and non-critically ill patients is uncertain.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Medicine, General & Internal
Mark Z. Y. Tan, Gabrielle Prager, Andrew Mcclelland, Paul Dark
Summary: The COVID-19 pandemic has tested global healthcare resilience and many previously considered 'resilient' countries have performed poorly. Existing organizational and system frameworks tend to be context-dependent and focus heavily on physical capacities. This study explores and synthesizes evidence about healthcare resilience and presents a unified framework for future resilience-building.
Article
Pediatrics
Yanshan Zhu, Flavia Jacqueline Almeida, J. Kenneth Baillie, Asha C. Bowen, Philip N. Britton, Martin Eduardo Brizuela, Danilo Buonsenso, David Burgner, Keng Yih Chew, Kulkanya Chokephaibulkit, Cheryl Cohen, Stephania A. Cormier, Nigel Crawford, Nigel Curtis, Camila G. A. Farias, Charles F. Gilks, Anne von Gottberg, Diana Hamer, Daniel Jarovsky, Waasila Jassat, Ana Rita Jesus, Lisa S. Kemp, Benjawan Khumcha, Georgina McCallum, Jessica E. Miller, Rosa Morello, Alasdair P. S. Munro, Peter J. M. Openshaw, Srivatsan Padmanabhan, Wanatpreeya Phongsamart, Gary Reubenson, Nicole Ritz, Fernanda Rodrigues, Supattra Rungmaitree, Fiona Russell, Marco A. P. Safadi, Christoph Saner, Malcolm G. Semple, Daniella Gregoria Bomfim Prado da Silva, Laise Marine Moura de Sousa, Marilia Diogo Moco Souza, Kirsten Spann, Sibongile Walaza, Nicole Wolter, Yao Xia, Daniel K. Yeoh, Heather J. Zar, Petra Zimmermann, Kirsty R. Short
Summary: This study investigates the impact of SARS-CoV-2 variants on the severity of COVID-19 in hospitalized children. The results suggest that while ICU admissions decrease across all age groups, ventilatory and oxygen support generally do not decrease significantly over time in children aged younger than 5 years.
Article
Endocrinology & Metabolism
Peter W. Horby, Natalie Staplin, Leon Peto, Jonathan R. Emberson, Mark Campbell, Guilherme Pessoa-Amorim, Buddha Basnyat, Louise Thwaites, Rogier van Doorn, Raph L. Hamers, Jeremy Nel, John Amuasi, Manisha Rawal, Dipansu Ghosh, Jonathan Douse, Fergus Hamilton, Anthony Kerry, Pinky Thu-Ta, John Widdrington, Christopher A. Green, Purav Desai, Richard Stewart, Nguyen Thanh Phong, J. Kenneth Baillie, Maya Buch, Saul N. Faust, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Marian Knight, Wei Shen Lim, Alan Montgomery, Aparna Mukherjee, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: Empagliflozin is not associated with reduced mortality, hospital stay, or progression to invasive mechanical ventilation or death in hospitalized adults with COVID-19.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Letter
Critical Care Medicine
Christopher E. Brightling, Rachael A. Evans, Amisha Singapuri, Nikki Smith, Louise Wain
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Betty Raman, Celeste McCracken, Mark P. Cassar, Alastair J. Moss, Lucy Finnigan, Azlan Helmy A. Samat, Godwin Ogbole, Elizabeth M. Tunnicliffe, Fidel Alfaro-Almagro, Ricarda Menke, Cheng Xie, Fergus Gleeson, Elena Lukaschuk, Hanan Lamlum, Kevin McGlynn, Iulia A. Popescu, Zeena-Britt Sanders, Laura Saunders, Stefan K. Piechnik, Vanessa M. Ferreira, Chrysovalantou Nikolaidou, Najib M. Rahman, Ling-Pei Ho, Victoria C. Harris, Aarti Shikotra, Amisha Singapuri, Paul Pfeffer, Charlotte Manisty, Onn Min Kon, Mark Beggs, Declan P. O'Regan, Jonathan Fuld, Jonathan R. Weir-McCall, Dhruv Parekh, Rick Steeds, Krisnah Poinasamy, Dan J. Cuthbertson, Graham J. Kemp, Malcolm G. Semple, Alexander Horsley, Christopher A. Miller, Caitlin O'Brien, Ajay M. Shah, Amedeo Chiribiri, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Marco Sereno, Ruth M. Saunders, Linzy Houchen-Wolloff, Neil J. Greening, Charlotte E. Bolton, Jeremy S. Brown, Gourab Choudhury, Nawar Diar Bakerly, Nicholas Easom, Carlos Echevarria, Michael Marks, John R. Hurst, Mark G. Jones, Daniel G. Wootton, Trudie Chalder, Melanie J. Davies, Anthony De Soyza, John R. Geddes, William Greenhalf, Luke S. Howard, Joseph Jacob, William D-C Man, Peter J. M. Openshaw, Joanna C. Porter, Matthew J. Rowland, Janet T. Scott, Sally J. Singh, David C. Thomas, Mark Toshner, Keir Lewis, Liam G. Heaney, Ewen M. Harrison, Steven Kerr, Annemarie B. Docherty, Nazir I. Lone, Jennifer K. Quint, Aziz Sheikh, Bang Zheng, Gisli Jenkins, Eleanor F. Cox, Susan Francis, Mark Halling-Brown, James D. Chalmers, John P. Greenwood, Sven Plein, Paul J. C. Hughes, A. A. Roger Thompson, Sarah Rowland-Jones, James M. Wild, Matthew Kelly, Thomas A. Treibel, Steven Bandula, Raminder Aul, Karla Miller, Peter Jezzard, Stephen Smith, Thomas E. Nichols, Gerry P. McCann, Rachael A. Evans, Louise V. Wain, Christopher E. Brightling, Stefan Neubauer
Summary: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. This study aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. The findings highlight the need for proactive multidisciplinary care pathways with imaging playing a potential role in guiding surveillance and treatment strategies.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Peter S. Cunningham, Gareth B. Kitchen, Callum Jackson, Stavros Papachristos, Thomas Springthorpe, David van Dellen, Julie Gibbs, Timothy W. Felton, Anthony J. Wilson, Jonathan Bannard-Smith, Martin K. Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur E. Akman, Andrew L. Hazel, John F. Blaikley
Summary: Researchers proposed a method called ClinCirc to measure circadian rhythms in hospitalized patients, which is challenging due to infrequent sampling. Through comparisons with simulated and frequently sampled biological data, ClinCirc showed high accuracy and revealed important clinical associations in the ICU patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)