Review
Gastroenterology & Hepatology
Katrina Clair Cockburn, Zaher Toumi, Alison Mackie, Peter Julyan
Summary: RGS appears to be beneficial in localizing gastrointestinal NETs, with more uncertain benefits in pancreatic NETs. Further research into factors such as tracer administration time and thresholding techniques is warranted.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Genetics & Heredity
Junchao Feng, Zhongchun Gao, Zhao Shi, Yue Wang, Shunping Li
Summary: This systematic review aimed to identify and analyze patient-reported outcomes (PROs) and outcome measures in Gaucher's disease (GD) patients. The study found that currently, the instruments used to measure PROs in GD are predominantly generic instruments, rather than disease-specific tools. However, a disease-specific instrument has been developed and validated, although its use is currently limited. Conclusion:The study is important for understanding the impact of GD on patients' quality of life and symptoms and highlights the need for improved PROs measurement and the development of disease-specific tools.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Gastroenterology & Hepatology
John E. Pandolfino, Dustin A. Carlson, Josie McGarva, Peter J. Kahrilas, Michael Vaezi, David Katzka, Tiffany H. Taft
Summary: The study developed a new Achalasia Patient-Reported Outcomes (APRO) Questionnaire, identified three subscales through investigation of patients with normal motility and achalasia, and found that symptom anxiety and hypervigilance moderate the relationship between APRO and quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Adrienne H. Kovacs, Gerald Lebovic, Stavroula Raptis, Samuel Blais, Christopher A. Caldarone, Nagib Dahdah, Frederic Dallaire, Christian Drolet, Jasmine Grewal, Camille L. Hancock Friesen, Edward Hickey, Gauri Rani Karur, Paul Khairy, Benedetta Leonardi, Michelle Keir, Brian W. McCrindle, Syed Najaf Nadeem, Ming-Yen Ng, Ashish H. Shah, Edythe B. Tham, Judith Therrien, Andrew E. Warren, Isabelle F. Vonder Muhll, Alexander Van de Bruaene, Kenichiro Yamamura, Michael E. Farkouh, Rachel M. Wald
Summary: This study explored the relationship between pulmonary regurgitation and quality of life and health status in adults with Tetralogy of Fallot (TOF), and found that with advancing age, patients reported more problems in mobility and pain or discomfort. Factors associated with superior patient-reported outcomes include race, syndrome, employment, and left ventricular function, while being asymptomatic was found to have the greatest impact on quality of life and health status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Andreas Denys, Yves van Nieuwenhove, Dirk Van de Putte, Eva Pape, Piet Pattyn, Wim Ceelen, Gabrielle H. van Ramshorst
Summary: This study analyzed the use of patient-reported outcome measures (PROMs) in pelvic exenteration (PE) patients. The results showed that while the use of validated questionnaires increased over time, there is still a need for uniform use and timing of PROMs to enable multicenter studies.
COLORECTAL DISEASE
(2022)
Review
Oncology
Noorazrul Yahya, Hanani Abdul Manan
Summary: Synthesizing evidence from multiple studies, we found that proton therapy has advantages over photon therapy in terms of quality of life and patient-reported outcomes for oropharyngeal cancers. However, further confirmation is needed through randomized controlled trials due to potential biases in the existing studies.
Review
Economics
Fabio Efficaee, Gary S. Collins, Francesco Cottone, Johannes M. Giesinger, Kathrin Sommer, Amelie Anota, Michael Maia Schlussel, Paola Fazi, Marco Vignetti
Summary: This systematic review found that PROs are statistically significant predictors of survival in cancer patients, with the EORTC QLQ-C30 questionnaire playing a particularly important role in predicting overall survival. Further research is needed to develop prognostic tools based on this evidence to assist in clinical decision-making.
Article
Oncology
Myung-Kyung Lee, Jihyun Oh
Summary: Exercise can have a synergistic effect on improving health-related quality of life (HRQOL) and depression in patients with gastric cancer, by indirectly positively affecting depression and directly influencing HRQOL.
Review
Oncology
Nora Tabea Sibert, Holger Pfaff, Clara Breidenbach, Simone Wesselmann, Christoph Kowalski
Summary: Patient-reported outcomes are being used to compare the quality of outcomes between different healthcare providers, but fair comparisons require case-mix adjustment to account for differences in patient populations. This systematic review identified various approaches to case-mix adjustment for patient-reported outcomes, highlighting the need for a standardized methodological guideline.
Article
Cardiac & Cardiovascular Systems
Onkar Khullar, Aubriana Perez, Meredith Dixon, Jose N. Binongo, Manu S. Sancheti, Allan Pickens, Theresa Gillespie, Seth D. Force, Felix G. Fernandez
Summary: This study examined the success of routine patient-reported outcomes (PROs) assessment in an academic-based thoracic surgery practice. Results showed that out of 9725 thoracic surgery office visits, PROs data were obtained in 6899 visits from 3551 patients. The overall questionnaire completion rate was 65.7%, with a significant decline in April 2020. Rating: 8 out of 10.
ANNALS OF THORACIC SURGERY
(2023)
Article
Oncology
Emily E. van Seventer, Madeleine G. Fish, Kathryn Fosbenner, Katie Kanter, Amirkasra Mojtahed, Jill N. Allen, Lawrence Blaszkowsky, Jeffrey W. Clark, Jon Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Therese Mulvey, Areej El-Jawahri, Nora Horick, Ryan B. Corcoran, Aparna R. Parikh, Ryan D. Nipp
Summary: This study found that baseline patient-reported outcomes (PROs) are associated with treatment response, healthcare utilization, and survival in patients with advanced gastrointestinal cancer. Specifically, physical symptoms and functional quality of life were correlated with disease progression and survival.
Review
Dentistry, Oral Surgery & Medicine
Gotfredsen Klaus
Summary: Evidence-based dentistry involves using evidence from the literature, clinical expertise, and patient expectations to make decisions and assess treatment. Patient satisfaction can be evaluated using questionnaires or structured questions and includes affability, availability, and ability. Questionnaires such as the oral health impact profile (OHIP) or the dental impact on daily living (DIDL) can be used to assess patient perception and quality of life. Patient-reported outcome measures (PROMs) have shown to enhance patient engagement and should be integrated into clinical care.
PERIODONTOLOGY 2000
(2023)
Article
Surgery
S. R. Markar, V Sounderajah, A. Johar, G. Zaninotto, C. Castoro, P. Lagergren, J. A. Elliott, S. S. Gisbertz, C. Mariette, R. Alfieri, J. Huddy, E. Pinto, M. Scarpa, F. Klevebro, B. Sunde, C. F. Murphy, C. Greene, N. Ravi, G. Piessen, H. Brenkman, J. Ruurda, R. van Hillegersberg, S. M. Lagarde, B. P. Wijnhoven, M. Pera, J. Roigg, S. Castro, R. Matthijsen, J. Findlay, S. Antonowicz, N. Maynard, O. McCormack, A. Ariyarathenam, G. Sanders, E. Cheong, S. Jaunoo, W. Allum, J. van Lanschot, M. Nilsson, J. Reynolds, M. I. van Berge Henegouwen, G. B. Hanna
Summary: Long-term symptom burden is common after oesophageal cancer surgery, with symptoms clustering into six domains: lethargy, musculoskeletal pain, dumping, lower gastrointestinal symptoms, regurgitation/reflux, and swallowing problems. Factors associated with severe symptoms include surgical approach, neoadjuvant therapy, patient age, and sex.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Dermatology
Yael Renert-Yuval, Joel Correa da Rosa, Sandra Garcet, Ana B. Pavel, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Summary: This study investigated the utility of two different alopecia areata-targeted questionnaires, and found that the Alopecia Areata Symptom Impact Scale (AASIS) correlated strongly with alopecia areata severity and clinical response. Patients with <= 20% scalp hair loss after treatment reported improvement in multiple quality-of-life items, which may guide clinicians and improve the development of future clinical trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Oncology
Victoria Huynh, Kathryn Colborn, Shelby Smith, Levi N. Bonnell, Gretchen Ahrendt, Nicole Christian, Simon Kim, Dan D. Matlock, Clara Lee, Sarah E. Tevis
Summary: This study aimed to compare longitudinal patient-reported outcomes between breast cancer patients undergoing lumpectomy and mastectomy, finding that mastectomy patients experienced significantly greater decreases in breast satisfaction, psychosocial well-being, and sexual well-being over time compared with lumpectomy patients, with lumpectomy patients more likely to return to baseline scores at 3 and 6 months postoperatively. Understanding these differences can inform early intervention strategies to prevent long-term morbidities.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Christine Eckhardt, Florian Krismer, Eveline Donnemiller, Sabine Eschlboeck, Alessandra Fanciulli, Cecilia Raccagni, Sylvia Boesch, Katherina Mair, Christoph Scherfler, Atbin Djamshidian, Christian Uprimny, Bernhard Metzler, Klaus Seppi, Werner Poewe, Stefan Kiechl, Irene Virgolini, Gregor K. Wenning
Summary: The purpose of this study was to evaluate the diagnostic accuracy of the dual imaging method combining cardiac iodine-(123)-metaiodobenzylguanidine single-photon emission computed tomography combined with low-dose chest computed tomography compared to routine cardiac scintigraphy, and assess regional differences in tracer distribution and the relationships between imaging and autonomic function in Parkinson's disease and multiple system atrophy.
CLINICAL AUTONOMIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Thomas Sonnweber, Philipp Grubwieser, Sabina Sahanic, Anna Katharina Boehm, Alex Pizzini, Anna Luger, Christoph Schwabl, Sabine Koppelstaetter, Katharina Kurz, Bernhard Puchner, Barbara Sperner-Unterweger, Katharina Huefner, Ewald Woell, Manfred Nairz, Gerlig Widmann, Ivan Tancevski, Judith Loeffler-Ragg, Guenter Weiss
Summary: This study describes iron dyshomeostasis in COVID-19 patients during follow-up and investigates its association with long-term pulmonary and symptomatic recovery. The study found that iron dyshomeostasis and anemia are common findings after COVID-19 and may contribute to long-term symptomatic outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Sviridenko, Anna Boehm, Gianpaolo di Santo, Christian Uprimny, Bernhard Nilica, Josef Fritz, Frederik L. Giesel, Uwe Haberkorn, Sabina Sahanic, Clemens Decristoforo, Ivan Tancevski, Gerlig Widmann, Judith Loeffler-Ragg, Irene Virgolini
Summary: This study explores the potential diagnostic benefit of PET/CT in identifying the underlying inflammatory or fibrotic repair processes in COVID-19 patients with prolonged lung abnormalities. The results show that Ga-68-FAPI-46 PET/CT had clear positivity in six pulmonary impaired patients, while F-18-FDG showed reduced glucose avidity compared to the control group.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luka Lezaic, Paola Anna Erba, Clemens Decristoforo, Katja Zaletel, Renata Mikolajczak, Helmut Maecke, Theodosia Maina, Mark Konijnenberg, Petra Kolenc, Malgorzata Trofimiuk-Mueldner, Elwira Przybylik-Mazurek, Irene Virgolini, Marion de Jong, Alide C. Froeberg, Christine Rangger, Gianpaolo Di Santo, Konrad Skorkiewicz, Piotr Garnuszek, Bogdan Solnica, Berthold A. Nock, Danuta Fedak, Paulina Gaweda, Alicja Hubalewska-Dydejczyk
Summary: This study demonstrates that [In-111]In-CP04 is a safe and effective radiopharmaceutical with theranostic characteristics for patients with advanced MTC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth von Guggenberg, Christian Uprimny, Maximilian Klinger, Boris Warwitz, Anna Sviridenko, Steffen Bayerschmidt, Gianpaolo di Santo, Irene J. Virgolini
Summary: PET/CT with 68Ga-DOTA-MGS5 shows potential in detecting local recurrence and metastases in patients with advanced MTC, with higher radiotracer accumulation observed at 2 h compared to 1 h after injection.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
Maria Rothmund, Micha J. J. Pilz, Nathalie Egeter, Emma Lidington, Claire Piccinin, Juan I. I. Arraras, Mogens Gronvold, Bernhard Holzner, Marieke van Leeuwen, Morten Aa. Petersen, Heike Schmidt, Teresa Young, Johannes M. M. Giesinger, EORTC Quality Life Grp
Summary: This study compared the content of commonly used patient-reported outcome measures (PROMs) and found that they cover 132 unique items primarily focusing on emotional functioning, with the majority of items falling under the third-level category of "emotional functions, other specified".
Article
Oncology
Rie von Eyben, Daniel S. Kapp, Manuela Andrea Hoffmann, Cigdem Soydal, Christian Uprimny, Irene Virgolini, Murat Tuncel, Mathieu Gauthe, Finn E. von Eyben
Summary: This study analyzed 1216 patients with PSA-only recurrence using [Ga-68]Ga-PSMA-11 PET/CT restaging and proposed a new risk model that significantly predicted overall survival. The study found that restaging PSMA PET/CT markedly predicted the 5-year OS and has potential use for patients with PSA-only recurrence.
Review
Oncology
Julian Mangesius, Stephanie Mangesius, Matthias Demetz, Christian Uprimny, Gianpaolo Di Santo, Malik Galijasevic, Danijela Minasch, Elke R. Gizewski, Ute Ganswindt, Irene Virgolini, Claudius Thome, Christian F. Freyschlag, Johannes Kerschbaumer
Summary: Radiation necrosis is a common problem in neuro-oncology, and interdisciplinary collaboration is necessary for image interpretation and patient management. This article provides an institutional guideline for using current imaging tools to differentiate radiation necrosis from tumor recurrence, and discusses therapeutic possibilities and future developments.
Article
Biochemistry & Molecular Biology
Leonhard Gruber, Clemens Decristoforo, Christian Uprimny, Peter Hohenberger, Stefan O. Schoenberg, Francesca Orlandi, Maurizio Franco Mariani, Claudia Manzl, Maria Theresia Kasseroler, Herbert Tilg, Bettina Zelger, Werner R. Jaschke, Irene J. Virgolini
Summary: This study reports the diagnostic properties and factors influencing the uptake of Ga-68-NeoBOMB1 in advanced gastrointestinal stromal tumor (GIST) patients. The results demonstrate variable tumor uptake in some patients, which is correlated with lesion vitality, suggesting its potential as a therapeutic approach in selected cases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Kratochwil, Wolfgang P. Fendler, Matthias Eiber, Michael S. Hofman, Louise Emmett, Jeremie Calais, Joseph R. Osborne, Amir Iravani, Phillip Koo, Liza Lindenberg, Richard P. Baum, Murat Fani Bozkurt, Roberto Delgado C. Bolton, Samer Ezziddin, Flavio Forrer, Rodney J. Hicks, Thomas A. Hope, Levent Kabasakal, Mark Konijnenberg, Klaus Kopka, Michael Lassmann, Felix M. Mottaghy, Wim J. G. Oyen, Kambiz Rahbar, Heiko Schoder, Irene Virgolini, Lisa Bodei, Stefano Fanti, Uwe Haberkorn, Ken Hermann
Summary: PSMA is expressed in most clinically significant prostate adenocarcinomas, and PSMA PET imaging can easily identify patients with target-positive disease. Early-phase studies have shown promising results with PSMA-targeted radiopharmaceutical therapy using different targeting molecules and radiolabels. [Lu-177]Lu-PSMA-617 in combination with standard-of-care has been demonstrated to be safe and effective in patients with metastatic castration-resistant prostate cancer. Ongoing phase 3 trials are evaluating the radiopharmaceuticals [Lu-177]Lu-PSMA-617 and [Lu-177]Lu-PSMA-I&T.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Correction
Oncology
Rie von Eyben, Daniel S. Kapp, Manuela Andrea Hoffmann, Cigdem Soydal, Christian Uprimny, Irene Virgolini, Murat Tuncel, Mathieu Gauthe, Finn E. von Eyben
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Marta Opalinska, Luka Lezaic, Clemens Decristoforo, Petra Kolenc, Renata Mikolajczak, Andrej Studen, Urban Simoncic, Irene Virgolini, Malgorzata Trofimiuk-Muldner, Piotr Garnuszek, Christine Rangger, Melpomeni Fani, Boguslaw Glowa, Konrad Skorkiewicz, Alicja Hubalewska-Dydejczyk
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Health Care Sciences & Services
David Riedl, Jens Lehmann, Maria Rothmund, Daniel Dejaco, Vincent Grote, Michael J. Fischer, Gerhard Rumpold, Bernhard Holzner, Thomas Licht
Summary: This study demonstrates the feasibility of using electronic patient-reported outcomes (ePRO) for assessing the subjective health status of older cancer patients. However, older patients may require assistance to complete home-based assessments, suggesting that in-house assessments may be more suitable for this population. It is crucial to consider the necessary resources to support patients in using ePRO devices.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Oncology
Micha Pilz, Maria Rothmund, Emma Lidington, Claire I. Piccinin, Juan Arraras, Mogens Groenvold, Bernhard Holzner, Marieke van Leeuwen, Morten Aa. Petersen, Heike Schmidt, Teresa M. Young, Johannes Giesinger, EORTC Qual Life Grp
Summary: This study aimed to evaluate the role functioning (RF) and social functioning (SF) contents assessed by commonly used PRO measures in cancer patients. Through linking item content to the ICF framework, conceptual overlap and differences among PRO measures for the assessment of social health were identified. These findings can help in selecting the most appropriate measure for a specific setting or study purpose, and understanding the possibilities of linking scores across different PRO measures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Sviridenko, Gianpaolo di Santo, Irene Virgolini