TRPM8 and Migraine

Potential Future Pharmacological Treatment of Bladder Dysfunction

(2016) Karl-Erik Andersson   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

TRPM8: a potential target for cancer treatment

(2016) Zhaoguo Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators

(2016) Alessia Bertamino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distribution of transient receptor potential melastatin-8-containing nerve fibers in rat oral and craniofacial structures

(2015) Takehiro Yajima et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'

(2015) K. Morgan et al.   BIOSCIENCE REPORTS

Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry andex vivomeasurements of single-unit mechanosensitive bladder afferent activities in the rat

(2015) Hiroki Ito et al.   BJU INTERNATIONAL

Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache

(2015) Carolina C Burgos-Vega et al.   CEPHALALGIA

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

(2015) Huiying Zhao et al.   CEPHALALGIA

TRP channels

(2015) Silvia Benemei et al.   CURRENT OPINION IN PHARMACOLOGY

Function and Postnatal Changes of Dural Afferent Fibers Expressing TRPM8 Channels

(2015) Lynn Ren et al.   Molecular Pain

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

(2015) Sonya G. Lehto et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Cancer treatment-related neuropathic pain: proof of concept study with menthol—a TRPM8 agonist

(2015) M. T. Fallon et al.   SUPPORTIVE CARE IN CANCER

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

(2015) Mark D. Andrews et al.   ACS Medicinal Chemistry Letters

TRPM8 is a neuronal osmosensor that regulates eye blinking in mice

(2015) Talisia Quallo et al.   Nature Communications

Targeting TRP Channels For Novel Migraine Therapeutics

(2014) Gregory Dussor et al.   ACS Chemical Neuroscience

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist

(2014) Masashi Ohmi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura

(2014) Cèlia Sintas et al.   CEPHALALGIA

Innervation of Rat and Human Dura Mater and Pericranial Tissues in the Parieto-Temporal Region by Meningeal Afferents

(2014) Markus Schueler et al.   HEADACHE

The TRPM8 Protein Is a Testosterone Receptor

(2014) Swapna Asuthkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

(2014) Daniel B. Horne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced Behavioral Responses to Cold Stimuli following CGRPα Sensory Neuron Ablation are Dependent on TRPM8

(2014) Eric S McCoy et al.   Molecular Pain

Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol

(2014) Ryan Patel et al.   PAIN

The Effects of a Co-Application of Menthol and Capsaicin on Nociceptive Behaviors of the Rat on the Operant Orofacial Pain Assessment Device

(2014) Ethan M. Anderson et al.   PLoS One

Central Connectivity of Transient Receptor Potential Melastatin 8-Expressing Axons in the Brain Stem and Spinal Dorsal Horn

(2014) Yun Sook Kim et al.   PLoS One

Antibodies to the Extracellular Pore Loop of TRPM8 Act as Antagonists of Channel Activation

(2014) Silke Miller et al.   PLoS One

Selectivity in Genetic Association with Sub-classified Migraine in Women

(2014) Daniel I. Chasman et al.   PLoS Genetics

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

(2013) Bin Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics

(2013) J Sousa-Valente et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRP channels in lower urinary tract dysfunction

(2013) J Franken et al.   BRITISH JOURNAL OF PHARMACOLOGY

Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

(2013) A.-L. Esserlind et al.   EUROPEAN JOURNAL OF NEUROLOGY

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artemin, a Glial Cell Line-Derived Neurotrophic Factor Family Member, Induces TRPM8-Dependent Cold Pain

(2013) E. K. Lippoldt et al.   JOURNAL OF NEUROSCIENCE

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Operant Behavioral Responses to Orofacial Cold Stimuli in Rats with Chronic Constrictive Trigeminal Nerve Injury: Effects of Menthol and Capsazepine

(2013) Xiaozhuo Zuo et al.   Molecular Pain

The TRPM8 channel forms a complex with the 5-HT1B receptor and phospholipase D that amplifies its reversal of pain hypersensitivity

(2013) Ignacio Vinuela-Fernandez et al.   NEUROPHARMACOLOGY

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain

(2013) Boyi Liu et al.   PAIN

Characterization of a novel model of chronic migraine

(2013) Amynah A. Pradhan et al.   PAIN

Transient Receptor Potential Channels Encode Volatile Chemicals Sensed by Rat Trigeminal Ganglion Neurons

(2013) Matthias Lübbert et al.   PLoS One

TRPM8 activation attenuates inflammatory responses in mouse models of colitis

(2013) R. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pirt functions as an endogenous regulator of TRPM8

(2013) Zongxiang Tang et al.   Nature Communications

Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

(2012) M. C. Almeida et al.   JOURNAL OF NEUROSCIENCE

Sensory Discrimination between Innocuous and Noxious Cold by TRPM8-Expressing DRG Neurons of Rats

(2012) Ignacio Sarria et al.   Molecular Pain

Expression of the Transient Receptor Potential Channels TRPV1, TRPA1 and TRPM8 in Mouse Trigeminal Primary Afferent Neurons Innervating the Dura

(2012) Dongyue Huang et al.   Molecular Pain

Transient Receptor Potential Melastatin 8 (TRPM8) Channels are Involved in Body Temperature Regulation

(2012) Narender R Gavva et al.   Molecular Pain

Genome-wide association analysis identifies susceptibility loci for migraine without aura

(2012) Tobias Freilinger et al.   NATURE GENETICS

Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons

(2012) A.H. Klein et al.   NEUROSCIENCE

Characterization of two neuronal subclasses through constellation pharmacology

(2012) R. W. Teichert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

(2011) Daniel I Chasman et al.   NATURE GENETICS

A novel role for TRPM8 in visceral afferent function

(2011) Andrea M. Harrington et al.   PAIN

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats

(2010) Amanda H. Klein et al.   BEHAVIOURAL BRAIN RESEARCH

Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose–petrosal ganglion complex

(2010) Aki Hondoh et al.   BRAIN RESEARCH

Migraine prevalence by age and sex in the United States: A life-span study

(2010) TW Victor et al.   CEPHALALGIA

TRPM8: From Cold to Cancer, Peppermint to Pain

(2010) Wendy M. Knowlton et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cutaneous application of menthol 10% solution as an abortive treatment of migraine without aura: a randomised, double-blind, placebo-controlled, crossed-over study

(2010) A. Borhani Haghighi et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

(2010) E. Zakharian et al.   JOURNAL OF NEUROSCIENCE

Menthol Response and Adaptation in Nociceptive-Like and Nonnociceptive-Like Neurons: Role of Protein Kinases

(2010) Ignacio Sarria et al.   Molecular Pain

Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

(2010) Andrés Parra et al.   NATURE MEDICINE

The development of peripheral cold neural circuits based on TRPM8 expression

(2010) Y. Takashima et al.   NEUROSCIENCE

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons

(2009) Susanne Staaf et al.   GENE EXPRESSION PATTERNS

Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder

(2009) Tokumasa Hayashi et al.   NEUROSCIENCE RESEARCH

Activity of the Neuronal Cold Sensor TRPM8 Is Regulated by Phospholipase C via the Phospholipid Phosphoinositol 4,5-Bisphosphate

(2008) Richard L. Daniels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections

(2008) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE

TRPM8 Mechanism of Autonomic Nerve Response to Cold in Respiratory Airway

(2008) Hong Xing et al.   Molecular Pain