Article
Immunology
Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs, Johann Steiner
Summary: This study found that levels of neutrophils and C-reactive protein were higher, while eosinophils were lower in patients with major depression compared to controls. The changes in neutrophil and eosinophil counts were smaller in major depression compared to schizophrenia. These findings suggest that innate immunity may be involved in early stages of major depression, while adaptive immunity may be involved in chronic disease.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Zixuan Hu, Jiaying Zhou, Yupeng Li, Yizhao Luan, Huan Li, Bo Jia, Zhi Xie, Bin Cheng, Tong Wu
Summary: This study explored the relationship between peripheral immune signatures and the survival of head and neck squamous cell carcinoma (HNSCC) patients. The peripheral neutrophil-to-lymphocyte ratio (pNLR) was identified as a significant prognostic indicator. Analysis of tumor RNA-seq data further confirmed the association between high tissue NLR and poor prognosis, as well as the enrichment of immune-related genes in different prognostic groups. The correlation between peripheral immune signatures and the tumor immune microenvironment (TIME) was confirmed in an independent cohort. Overall, the findings suggest that pNLR is a feasible prognostic signature reflecting the TIME patterns in HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sophie Wildsmith, Weimin Li, Song Wu, Ross Stewart, Nassim Morsli, Rajiv Raja, Qu Zhang, Jiabu Ye, Philip He, Jagdish Shetty, Alejandro Yovine, Nicholas Holoweckyj, Katia Real, Jill Walker, Magdalena Wrona, Melissa de los Reyes, Craig Barker, Jessica Whiteley, Robert Haddad, Lisa Licitra, Robert Ferris, Jerome Fayette, Dan P. Zandberg, Lillian L. Siu, Ricard Mesia
Summary: This study found that tumor mutational burden can serve as a biomarker to predict survival in patients with recurrent or metastatic head and neck squamous cell carcinoma treated with immune check-point inhibitors. By analyzing tumor samples and blood samples from clinical trials, it was found that high mutational burden is associated with longer survival.
CLINICAL CANCER RESEARCH
(2023)
Article
Otorhinolaryngology
Masaaki Higashino, Kosuke Sugimoto, Shuji Onishi, Kohei Okabe, Chika Yasuda, Hiroshi Tadokoro, Ryo Kawata
Summary: This study found that PPI and NLR indicators are associated with the prognosis of patients with end-stage HNSCC. Patients with PPI ≥6 and NLR ≥10 have poorer prognosis and shorter median survival. Therefore, the combination of PPI and NLR is a useful indicator for predicting the prognosis of patients with end-stage HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Review
Dentistry, Oral Surgery & Medicine
Pierluigi Mariani, Diana Russo, Marco Maisto, Giuseppe Troiano, Vito Carlo Alberto Caponio, Marco Annunziata, Luigi Laino
Summary: The study showed that a higher pre-treatment NLR value is associated with a significant decrease in overall survival and disease-free survival rates in HNSCC patients.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Oncology
Siwei Zhang, Bozhi Wang, Fen Ma, Fangjia Tong, Bingqing Yan, Tianyang Liu, Huanhuan Xie, Lianhao Song, Siyang Yu, Lanlan Wei
Summary: The study revealed that HPV+ HNSCC patients have higher infiltration of plasma cells and memory B cells, which is correlated with better prognosis. The high density of B lymphocytes is positively correlated with high CXCL13 production mainly from CD4(+) T lymphocytes, indicating excellent prognosis prediction.
Article
Multidisciplinary Sciences
Kenro Tanoue, Shingo Tamura, Hitoshi Kusaba, Yudai Shinohara, Mamoru Ito, Kenji Tsuchihashi, Tsuyoshi Shirakawa, Taiga Otsuka, Hirofumi Ohmura, Taichi Isobe, Hiroshi Ariyama, Sakuya Koreishi, Yuzo Matsushita, Hozumi Shimokawa, Risa Tanaka, Kenji Mitsugi, Koichi Akashi, Eishi Baba
Summary: The study found that the pretreatment C-reactive protein/albumin ratio (CAR) may serve as an independent marker for prognosis and efficacy in patients with recurrent or metastatic head and neck cancer treated with nivolumab, with high CAR patients showing lower overall survival and progression-free survival rates.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Mario Sanchez-Canteli, Luis Juesas, Esther Redin, Alfonso Calvo, Fernando Lopez, Aurora Astudillo, Luis M. Montuenga, Juana M. Garcia-Pedrero, Juan P. Rodrigo
Summary: The study found that PD-L1 protein expression was correlated with the density of CD8+ and FOXP3+ tumor infiltrating lymphocytes, but not with the neutrophil-to-lymphocyte ratio. In HNSCC patients receiving induction chemotherapy, a high NLR may predict the response to ICT and is associated with lower disease-specific and overall survival rates.
Article
Health Care Sciences & Services
Giovanni Salzano, Francesco Perri, Fabio Maglitto, Giulia Togo, Gianluca Renato De Fazio, Michela Apolito, Federica Calabria, Claudia Laface, Luigi Angelo Vaira, Umberto Committeri, Mario Balia, Ettore Pavone, Corrado Aversa, Francesco Antonio Salzano, Vincenzo Abbate, Alessandro Ottaiano, Marco Cascella, Mariachiara Santorsola, Roberta Fusco, Luigi Califano, Franco Ionna
Summary: This study retrospectively reviewed data of LSCC patients and found a significant correlation between high NLR values and neck occult metastasis, with an NLR value of 2.26 corresponding to a 20% probability of OM.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Review
Oncology
Juan P. Rodrigo, Mario Sanchez-Canteli, Asterios Triantafyllou, Remco de Bree, Antti A. Maekitie, Alessandro Franchi, Henrik Hellquist, Nabil F. Saba, Goeran Stenman, Robert P. Takes, Cristina Valero, Nina Zidar, Alfio Ferlito
Summary: Neutrophil-to-lymphocyte ratio (NLR) has been associated with prognosis in various cancers, including head and neck cancer. However, its prognostic value in oropharyngeal carcinomas (OPSCC), especially in relation to HPV status, is limited. This meta-analysis shows that an elevated pretreatment NLR is associated with worse outcomes in OPSCC, specifically in HPV-positive cases. NLR could serve as an affordable prognostic marker in HPV-positive OPSCC.
Article
Oncology
Zhiguo Liu, Hongyan Liu, Qian Dong, Hongyu Li, Bin Zhang, Yufeng Liu, Limei Zhong, Haikuo Tang
Summary: The study found that DFNA5 expression is prognostic for patients with HNSCC, with higher levels associated with worse survival. DFNA5 may function in HNSCC by regulating lymphocyte infiltration.
Article
Oncology
Tomoki Abe, Taro Oshikiri, Hironobu Goto, Takashi Kato, Manabu Horikawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
Summary: The Alb-dNLR score has been shown to be an independent prognostic factor for ESCC patients, and can predict both overall survival and cause-specific survival rates by analyzing albumin and the neutrophil-to-lymphocyte ratio.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Otorhinolaryngology
M. Casasayas, A. Sansa, J. Garcia-Lorenzo, M. del Prado Venegas, M. Quer, X. Leon
Summary: This study found that there were no significant differences in the pharyngocutaneous fistula rate after total laryngectomy depending on the previous treatment with radiotherapy or chemoradiotherapy, or depending on the interval between radiotherapy treatment and surgery. Patients who received chemoradiotherapy required surgical repair more frequently.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2022)
Review
Otorhinolaryngology
Carlos M. Chiesa-Estomba, Jose A. Gonzalez-Garcia, Eric M. Genden, Cesare Piazza, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Luiz P. Kowalski, Fernando Lopez, Miquel Quer, Juan P. Rodrigo, Alvaro Sanabria, Veronica Fernandez-Alvarez, Carlos Suarez, Oded Cohen, Remco de Bree, Ashok R. Shaha, Antti A. Makitie, Alfio Ferlito
Summary: This study systematically reviewed and qualitatively analyzed methods for vascular perfusion assessment in Head and Neck microsurgical reconstruction. The results indicated that Cook-Swartz IDP is a safe and effective device. Further detailed prospective registration is needed to accurately evaluate results and complications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Xavier Leon, Gerard Pujals, Blanca Sauter, Eduard Neumann, Albert Pujol, Miquel Quer
Summary: This study aimed to analyze the differential characteristics of HNSCC patients without a history of toxic substance consumption. Through a retrospective study of 4,694 HNSCC patients treated in our center from 1985 to 2019, it was found that 7.7% of patients did not report a history of toxic substance consumption. Patients without a toxic history were older, had a higher proportion of women, a higher frequency of cases located in the oral cavity, a higher proportion of early-stage diagnoses, and a lower incidence of second neoplasms. The overall survival of patients without a history of toxic substance consumption was significantly higher than that of patients with toxic substance use.
ACTA OTORRINOLARINGOLOGICA ESPANOLA
(2023)
Article
Otorhinolaryngology
Aina Sansa, Cristina Valero, Anna Holgado, Rosselin Vasquez, Miquel Quer, Snehal G. Patel, Xavier Leon
Summary: This study validates the prognostic capacity of the H-index in patients with HNSCC, regardless of the primary tumor location, disease extent, or treatment performed.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Biochemistry & Molecular Biology
Nuria Puig, Jose Rives, Montserrat Estruch, Ana Aguilera-Simon, Noemi Rotllan, Mercedes Camacho, Nuria Colome, Francesc Canals, Jose Luis Sanchez-Quesada, Sonia Benitez
Summary: Electronegative low-density lipoprotein (LDL(-)) is a modified fraction of human plasma LDL with atherogenic properties, including increased bioactive lipid mediator content. The present study suggests the presence of ceramidase (CDase)-like activity in LDL(-), which is associated with the increased sphingosine (Sph) content. However, the exact origin of this activity remains unknown and requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Otorhinolaryngology
O. Laccourreye, H. Mirghani, S. Guiquerro, M. Quer, P. Giraud
Summary: This study evaluated the perception of the survival/laryngeal preservation trade-off in advanced T-stage laryngeal cancer. The findings showed that some patients had difficulty making a decision between treatment options, while others preferred to prioritize laryngeal preservation over survival. Factors such as patient status, occupation, and treatment data were found to influence the perception of trade-off.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Review
Oncology
Juan P. Rodrigo, Mario Sanchez-Canteli, Asterios Triantafyllou, Remco de Bree, Antti A. Maekitie, Alessandro Franchi, Henrik Hellquist, Nabil F. Saba, Goeran Stenman, Robert P. Takes, Cristina Valero, Nina Zidar, Alfio Ferlito
Summary: Neutrophil-to-lymphocyte ratio (NLR) has been associated with prognosis in various cancers, including head and neck cancer. However, its prognostic value in oropharyngeal carcinomas (OPSCC), especially in relation to HPV status, is limited. This meta-analysis shows that an elevated pretreatment NLR is associated with worse outcomes in OPSCC, specifically in HPV-positive cases. NLR could serve as an affordable prognostic marker in HPV-positive OPSCC.
Article
Biochemistry & Molecular Biology
Nuria Puig, Pol Camps-Renom, Arnau Sole, Ana Aguilera-Simon, Elena Jimenez-Xarrie, Alejandro Fernandez-Leon, Mercedes Camacho, Marina Guasch-Jimenez, Rebeca Marin, Joan Marti-Fabregas, Alejandro Martinez-Domeno, Luis Prats-Sanchez, Francesca Casoni, Belen Perez, Francesc Jimenez-Altayo, Jose Luis Sanchez-Quesada, Sonia Benitez
Summary: This study aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in patients with ischemic stroke and carotid atherosclerosis. Patients showed lower levels of cholesterol and apolipoproteins, as well as lower enzymatic activities of PAF-AH and PON-1 in HDL and higher levels of oxidized LDL and electronegative LDL. The proportion of LDL(-) was independently associated with carotid stenosis, hypoechoic plaque presence, and diffuse neovessels.
Article
Oncology
John R. de Almeida, Jie Susie Su, Mirko Manojlovic Kolarski, Tra Truong, Ilan Weinreb, Bayardo Perez-Ordonez, Stephen M. Smith, Ali Hosni, Snehal Patel, Cristina Valero, Bin Xu, Ronald Ghossein, Nora Katabi, Jonathan Clark, Tsu-Hui (Hubert) Low, Ruta Gupta, Evan M. Graboyes, Joel Davies, Mary Richardson, Vishu Pasham, Rachel Jester, David P. Goldstein, Shao Hui Huang, Wei Xu, Brian O'Sullivan
Summary: This study examined the lymph node characteristics of oral cavity squamous cell carcinoma patients and established a new N-classification method. The results showed that the new N classification method has better staging performance compared to TNM-8-N.
Article
Biophysics
Jan Trallero, Mercedes Camacho, Maribel Marin-Garcia, Elena Alvarez-Marimon, Nuria Benseny-Cases, Ramon Barnadas-Rodriguez
Summary: The discovery that carbon monoxide is a gasotransmitter involved in biological processes has increased its scientific relevance. This led to the synthesis of CO-releasing molecules for secure and targeted delivery. In this study, a vesicular CO delivery system composed of a metallosurfactant (TCOL10) and a molybdenum-carbonyl complex triggered by light was presented. The metallosomes showed stable characteristics and a lag phase before spontaneous CO release, and large vesicles were more efficiently internalized by cells compared to smaller ones.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nutrition & Dietetics
Jeimy Katherine Torres-Mendez, Julia Nino-Narvion, Patricia Martinez-Santos, Elena Maria Goretti Diarte-Anazco, Karen Alejandra Mendez-Lara, Tania Vazquez del Olmo, Noemi Rotllan, Maria Teresa Julian, Nuria Alonso, Didac Mauricio, Mercedes Camacho, Juan Pablo Munoz, Joana Rossell, Josep Julve
Summary: This study investigated the effects of nicotinamide (NAM) supplementation on brain inflammation and microglial activation in a mouse model of type 1 diabetes. The results showed that NAM supplementation prevented brain inflammation in diabetic mice through NAD+-dependent deacetylation mechanisms.
Article
Medicine, Research & Experimental
Cristina Valero, Mahdi Golkaram, Joris L. Vos, Bin Xu, Conall Fitzgerald, Mark Lee, Shannon Kaplan, Catherine Y. Han, Xin Pei, Reith Sarkar, Lillian A. Boe, Abhinav Pandey, Elizabeth S. Koh, Charlotte L. Zuur, David B. Solit, Traci Pawlowski, Li Liu, Alan L. Ho, Diego Chowell, Nadeem Riaz, Timothy A. Chan, Luc G. T. Morris
Summary: This study analyzed the clinical and genomic features of 133 ICB-treated patients with R/M HNSCC and identified 6 molecular subtypes that determine the response to ICB therapy. A predictive model based on clinical and genomic features outperformed the current biomarker of TMB alone. This validated predictive tool can help with clinical risk stratification in patients with R/M HNSCC considering ICB treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Neelam Sinha, Sanju Sinha, Cristina Valero, Alejandro A. Scha, Kenneth Aldape, Kevin Litch, Timothy A. Chan, Luc G. T. Morris, Eytan Ruppin
Summary: This study uncovers immune-related factors that may modulate the relationship between high tumor mutational burden and ICI response, which can help prioritize cancer types for clinical trials.
