Article
Pharmacology & Pharmacy
Federico Cucchiara, Sara Ferraro, Giacomo Luci, Guido Bocci
Summary: This review focuses on the interactions between alkylating agents and AEDs, providing guidance for rational treatment optimization to improve patients' quality of life. Clinicians should avoid using enzyme-inducing AEDs with alkylating agents and carefully monitor therapeutic drug levels to prevent adverse reactions.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Weiyi Cao, Qiaoning Yang, Wantong Zhang, Yonggang Xu, Shuge Wang, Yi Wu, Yang Zhao, Zhongning Guo, Rui Li, Rui Gao
Summary: This study found a pharmacokinetic drug-drug interaction between aspirin and salvianolate, with no difference in pharmacodynamics between the A + S and AP groups, but the combination group showed superior P2Y12 expression compared to the SV group.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Behdad Jahromi, Iulia Pirvulescu, Kenneth D. Candido, Nebojsa Nick Knezevic
Summary: Herbal medicines, although not part of conventional medicine, have gained attention for their efficacy and safety concerns. Due to their alternative role in treating pain traditionally managed by conventional therapies, clinical studies have focused on herbal medicines.
Article
Infectious Diseases
Joachim Andreas Koeck, Heike Hilgarth, Andreas von Ameln-Mayerhofer, Damaris Meyn, Ruediger Warlich, Andreas Muenstedt, Dagmar Horn, Christina Koenig
Summary: ICU patients are at high risk of drug-drug interactions due to polypharmacy, but little is known about the type and frequency of DDIs within German ICUs. Clinical pharmacists' interventions in a national database were filtered for ICU patients, and a Delphi process was employed to evaluate and develop guidance for clinical practice. Most DDIs involved macrolides, antifungals, or fluoroquinolones, highlighting the need for inter-professional discussion in managing DDIs for individual patients.
Article
Green & Sustainable Science & Technology
Adeli Beatriz Braun, Caroline Visentin, Adan William da Silva Trentin, Antonio Thome
Summary: This study developed a comprehensive list of 63 sustainable remediation indicators, validated them with experts from around the world, and determined their weights through a Likert scoring scale. Experts showed a greater emphasis on environmental and social indicators over economic ones, indicating a balance in sustainability dimensions.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Neurosciences
Tram T. Le, Sarah R. McGrath, Pius S. Fasinu
Summary: The use of herbal products as complementary medicine alongside prescription neuropsychiatric drugs is common, but it can lead to herb-drug interactions that may jeopardize the success of pharmacotherapy. This study identified 13 commonly used herbal products that have clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders, emphasizing the importance of caution in herb-drug co-medication.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Cell Biology
Lauren E. Kueffer, Raji E. Joseph, Amy H. Andreotti
Summary: BTK, a multidomain tyrosine kinase, plays a crucial role in primary immunodeficiency and B cell malignancies. Current therapeutic interventions target BTK, but are hindered by resistance mutations. Research focuses on the molecular mechanisms driving drug resistance and exploring new treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anne T. Nies, Joerg Koenig, Ute Hofmann, Charlotte Koelz, Martin F. Fromm, Matthias Schwab
Summary: Remdesivir has been approved for COVID-19 treatment, but the study indicates that OATP1B1 and its genetic variants, OATP1B3, OATP2B1 and OCT1, are not relevant for the hepatic uptake of the drug in humans. This suggests that there are no clinically relevant transporter-mediated drug interactions expected due to the rapid clearance of remdesivir.
Article
Pharmacology & Pharmacy
Kyeong-Ryoon Lee, Ji-Eun Chang, Jongmin Yoon, Hyojeong Jin, Yoon-Jee Chae
Summary: Understanding the necessity of labeling for drug interactions based on in vitro findings is important. This study analyzed the in vitro findings and follow-up actions for drugs approved by the FDA's Center for Drug Evaluation and Research in the last five years. It was found that a certain percentage of drugs showed higher interaction values in in vitro studies, and some of them were labeled with potential drug interactions with supporting studies or scientific rationales. Other drugs were not labeled for interactions based on clinical studies or scientific rationales. This systematic and comprehensive analysis provides insights into the management of in vitro findings for transporter substrate or inhibitor drugs.
Review
Plant Sciences
Claude Becker, Richard Berthome, Philippe Delavault, Timothee Flutre, Helene Freville, Stephanie Gibot-Leclerc, Valerie Le Corre, Jean-Benoit Morel, Nathalie Moutier, Stephane Munos, Celine Richard-Molard, James Westwood, Pierre-Emmanuel Courty, Alexandre de Saint Germain, Gaetan Louarn, Fabrice Roux
Summary: Interactions among plants are important for plant community dynamics and crop yield, but our understanding of the genetics associated with these interactions is limited. By studying phenotypic traits and their underlying genetic and molecular pathways, and considering environmental fluctuations, we can improve our predictions and modeling of plant interactions in wild habitats and crop fields.
TRENDS IN PLANT SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Cesar Augusto Roque-Borda, Marcos William de Lima Gualque, Fauller Henrique da Fonseca, Fernando Rogerio Pavan, Norival Alves Santos-Filho
Summary: Diseases such as cancer and infectious diseases are major causes of death worldwide, with their causative agents developing resistance to existing treatments. Biomacromolecules have therapeutic properties that are yet to be fully studied, representing a potential source for new drugs. Nanotechnology is helping to overcome challenges such as low bioavailability and stability of biomacromolecules in biological systems.
Article
Pharmacology & Pharmacy
Michael Hecker, Niklas Frahm, Paula Bachmann, Jane Louisa Debus, Marie-Celine Haker, Pegah Mashhadiakbar, Silvan Elias Langhorst, Julia Baldt, Barbara Streckenbach, Felicita Heidler, Uwe Klaus Zettl
Summary: This study compared three different screening tools for the detection and classification of potential drug-drug interactions (pDDIs) in multiple sclerosis (MS) patients, and identified factors associated with severe pDDIs. The results showed heterogeneity in the information on pDDIs between the examined databases, suggesting that multiple resources should be used in clinical practice to evaluate pDDIs. Regular medication reviews and information exchange between treating physicians can help prevent severe pDDIs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agronomy
Jessica Graca, Giulia Bondi, Achim Schmalenberger, Karen Daly
Summary: This study examined the distribution of labile and non-labile soil P fractions in temperate grasslands and identified the properties that influence their distribution. The results suggest that the Mehlich3 reagent is a better indicator for soil P dynamics and improved P advice to farmers.
Article
Pharmacology & Pharmacy
Chen Ning, Shengdi Su, Jiaming Li, Dexuan Kong, Hui Cai, Zhiying Qin, Han Xing, Xijing Chen, Jiake He
Summary: The study identified the impact of clopidogrel and its metabolite on the transport of rosuvastatin, potentially leading to hepatotoxicity. The findings suggest that clopidogrel can affect the metabolism and efficacy of rosuvastatin by inhibiting the transmembrane transport proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Arpad Turcsanyi, Ditta Ungor, Marek Wojnicki, Edit Csapo
Summary: Fabrication protocol of BSA- and LYZ-stabilized Au/Ag NCs was optimized by adjusting the protein/metal ion ratios, metal concentration, pH, and incubation time. The incorporation of silver into the gold core significantly enhanced the fluorescence properties of the nanoclusters. The stability of the bimetallic NCs during interaction with biocolloids was much higher compared to monometallic derivatives, indicating their potential as fluorescent reporters in biomedical applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)