TRUST trial: BAY 86-6150 use in haemophilia with inhibitors and assessment for immunogenicity

A new report of FVII-inhibitor in a patient suffering from severe congenital FVII deficiency

(2015) M. Borhany et al.   HAEMOPHILIA

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity

(2015) J. N. Mahlangu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics

(2014) Boris Gorovits et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Predicting dosing advantages of factor VIIa variants with altered tissue factor-dependent and lipid-dependent activities

(2014) A. M. Shibeko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recombinant factor VIIa analog in the management of hemophilia with inhibitors: results from a multicenter, randomized, controlled trial of vatreptacog alfa

(2014) S. R. Lentz et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Coagulation factor VII variants resistant to inhibitory antibodies

(2014) Caroline Pfeiffer et al.   THROMBOSIS AND HAEMOSTASIS

40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors

(2013) R. Ljung et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP)

(2013) S. Zollner et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibitors: our greatest challenge. Can we minimize the incidence?

(2012) R. Kruse-Jarres   HAEMOPHILIA

Guidelines for the management of hemophilia

(2012) A. Srivastava et al.   HAEMOPHILIA

Phase I, randomized, double-blind, placebo-controlled, single-dose escalation study of the recombinant factor VIIa variant BAY 86-6150 in hemophilia

(2012) J. N. MAHLANGU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibitors of propagation of coagulation (factors VIII, IX and XI): a review of current therapeutic practice

(2010) Massimo Franchini et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene

(2009) F. H. HERRMANN et al.   HAEMOPHILIA