Article
Microbiology
Jeremy J. Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Sanjay Kumar Singh, Simon Arunga, Victor H. Hu, David Macleod, Astrid Leck, Matthew J. Burton
Summary: This study investigated the clinical and epidemiological features of microbial keratitis in Nepal and developed a predictor score to determine the microbial aetiology. Fungal infection was found to be the main cause of keratitis, with dematiaceous fungi being particularly prevalent. Serrated infiltrate margins, patent nasolacrimal duct, raised corneal slough, and organic trauma were identified as independent predictors of fungal keratitis.
Article
Medicine, General & Internal
Sarah Atta, Rohan Bir Singh, Keerthana Samanthapudi, Chandrashan Perera, Mahmoud Omar, Shannon Nayyar, Regis P. Kowalski, Vishal Jhanji
Summary: This retrospective case series evaluated the clinical history and presentation of culture and PCR-negative infectious keratitis cases. Out of 121 cases included, the most common presumed etiology at presentation was viral (38.01%) followed by bacterial (27.27%) and fungal (8.26%). Risk factors included ocular surface diseases and contact lens use. The visual outcomes were generally favorable, but a history of ocular surface disease and poor contact lens hygiene were associated with worse outcomes.
Article
Public, Environmental & Occupational Health
Jingjing Luo, Xia Yu, Lingling Dong, Fengmin Huo, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang
Summary: This study aimed to identify the causes of smear-positive-culture-negative (S+/C-) outcomes in tuberculosis patients during treatment. A retrospective study was conducted at Beijing Chest Hospital in China. The results showed that the S+/C- rates were higher in the liquid culture group compared to the solid culture group.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Ophthalmology
Davide Borroni, Chiara Bonzano, Jose-Maria Sanchez-Gonzalez, Rahul Rachwani-Anil, Francisco Zamorano-Martin, Jorge Pereza-Nieves, Carlo Enrico Traverso, Maria Garcia Lorente, Marina Rodriguez-Calvo-de-Mora, Alfonso Esposito, Fernando Godin, Carlos Rocha-de-Lossada
Summary: Shotgun metagenomics analysis was used to evaluate the microbiota of culture negative Corneal Impression Membrane (CIM) microbial keratitis samples. The study found that Brevundimonas diminuta was present in 5 samples, viral infections were detected in 6 samples, and Cutibacterium acnes, Staphylococcus aureus, Moraxella lacunata, and Pseudomonas alcaligenes were identified as the presumed putative cause of infection in 7 samples.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Semir Yarimada, Ozlem Barut Selver, Melis Palamar, Sait Egrilmez, Sabire Sohret Aydemir, Suleyha Hilmioglu Polat, Ayse Yagci
Summary: This study evaluated and compared the risk factors, presenting features, and outcomes of patients with culture-positive and culture-negative microbial keratitis. The results showed that contact lens wear and younger age were more common in the culture-positive group. Bacterial infection was the most common pathogen, with Pseudomonas aeruginosa being the most common single pathogen.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Matthew Green, Susan Zhang, Thomas Nadivulath, Andrew Apel, Fiona Stapleton
Summary: This study found that positive cultures in suspected microbial keratitis were associated with older age, poor visual acuity, contact lens-related keratitis, anterior chamber reaction, and no prior treatment with antibiotics.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Psychology, Multidisciplinary
Shuyuan Xu, Yuyan Sun, Min Huang, Yanhong Huang, Jing Han, Xuemei Tang, Wei Ren
Summary: The study found that different reinforcement types did not show significant differences in learning signals, but negative reinforcement induced smaller FRN waves, stronger positive emotions and happiness, and less fatigue after learning.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Ophthalmology
Abdulmohsen Almulhim, Muhannad I. I. Alkhalifah, Hatem Kalantan, Waleed K. K. Alsarhani
Summary: This study reviewed the clinical features, causative organisms, complications, and outcomes of bacterial keratitis cases at a tertiary eye hospital. The study found that gram-positive bacteria were the most common causative organisms and complications included visual impairment and corneal perforation. Factors such as diabetes, poor presenting visual acuity, and positive cultures were associated with poor outcomes.
Article
Ophthalmology
Antonio Di Zazzo, Mugundhan Rajan, Rohit Dureja, Marco Antonini, Vaibhav Kanduri, Bhagyasree Madduri, Nitin Mohan, Ashik Mohamed, Merle Fernandes
Summary: This study retrospectively analyzed the risk factors, microbiological profile, and treatment efficacy in pediatric microbial keratitis, finding that ulcer location and size are key factors affecting resolution time. Empirical therapy can be considered for culture negative cases, but the importance of microbiological workup cannot be underestimated.
Article
Psychology, Experimental
Catherine J. Norris, Emily Wu
Summary: Ambivalence, feeling both positivity and negativity at the same time, is an uncomfortable but necessary catalyst for behavior change. Instructed emotion regulation of positive and negative affect can reduce feelings of ambivalence, with negative emotions being harder to regulate compared to positive ones, indicating a negativity bias in affective processing.
Letter
Ophthalmology
Davide Borroni
Summary: Metagenomics Next-Generation Sequencing provides taxonomic and functional profiles of microbial keratitis communities without the need for culture. In cases with negative culture but positive metagenomic results, this method can offer valuable insights for diagnosis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Medicine, General & Internal
Susanna Sagerfors, Chrysoula Karakoida, Martin Sundqvist, Birgitta Ejdervik Lindblad, Bo Soderquist
Summary: The study compared two different methods of corneal culture in infectious keratitis, with the standard method yielding higher proportions of positive culture outcomes and microorganisms compared to the indirect inoculation method. However, a combination of direct and indirect inoculation could reduce the number of corneal samples without significant differences in culture outcomes or proportion of detected microorganisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Anasua G. Kapoor, Vijitha S. Vempuluru, Srujana Laghimshetty, Aravind Roy, Savitri Sharma, Dilip K. Mishra, Ashik Mohamed, Swathi Kaliki
Summary: The study evaluated the incidence, clinical features, microbiology, risk factors, and treatment outcomes of ocular surface squamous neoplasia (OSSN) coexisting with microbial keratitis (MK). The results showed that the combination of MK and OSSN led to poor treatment outcomes, and risk factors for this association included male sex, human immunodeficiency virus seropositivity, large limbal pigmented OSSN lesion, noduloulcerative morphology, and scleral invasion.
Article
Political Science
Alexa Bankert
Summary: Researchers have developed and validated a multi-item scale to measure negative partisan identity; they found that most Americans have both negative and positive partisan identities, but the two are independent constructs; and compared the differential effects of negative and positive partisan identities on predicting political behaviors.
POLITICAL BEHAVIOR
(2021)
Correction
Multidisciplinary Sciences
Aris Konstantopoulos, Maria del Mar Cendra, Michael Tsatsos, Mariam Elabiary, Myron Christodoulides, Parwez Hossain
Summary: The paper has been amended and the amended version can be accessed through the link at the top of the paper.
SCIENTIFIC REPORTS
(2021)