Article
Obstetrics & Gynecology
Carolina von Grothusen, Caroline Frisendahl, Vijayachitra Modhukur, Parameswaran Grace Lalitkumar, Maire Peters, Omid R. Faridani, Andres Salumets, Nageswara Rao Boggavarapu, Kristina Gemzell-Danielsson
Summary: This study compares the abundance of miRNAs in uterine fluid between healthy fertile women and women with recurrent implantation failure (RIF). The results show that the composition of miRNAs in RIF uterine fluid is different from that of healthy fertile women, and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation. These findings shed light on the molecular mechanisms behind RIF and may have implications for future biomarker and clinical treatment studies.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
Jason M. Franasiak, Diana Alecsandru, Eric J. Forman, Laura C. Gemmell, Jeffrey M. Goldberg, Natalia Llarena, Cheri Margolis, Joop Laven, Sam Schoenmakers, Emre Seli
Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra E. Mrozikiewicz, Marcin Ozarowski, Piotr Jedrzejczak
Summary: Infertility affects 8-12% of reproductive age couples worldwide, with a significant impact on women experiencing recurrent implantation failure (RIF). RIF is a complex condition involving various physiological and molecular mechanisms, with studies suggesting associations with hormone level imbalances, disturbances of angiogenic and immunomodulatory factors, certain genetic polymorphisms, and ethnicity-related inconsistencies. This review highlights the importance of factors contributing to RIF development, potentially paving the way for new diagnostic and therapeutic solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Konstantinos Pantos, Sokratis Grigoriadis, Evangelos Maziotis, Kalliopi Pistola, Paraskevi Xystra, Agni Pantou, Georgia Kokkali, Athanasios Pappas, Maria Lambropoulou, Konstantinos Sfakianoudis, Mara Simopoulou
Summary: Recurrent implantation failure (RIF) is a complex condition affecting 10-15% of IVF couples. Dysregulation of interleukins (ILs), which are involved in immune responses, plays a crucial role in the pathogenesis of RIF. Further research is needed to understand the molecular mechanisms of ILs in order to provide evidence-based consultancy and decision making for RIF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Sophea Heng, Nirukshi Samarajeewa, Asma Aberkane, Wafaa Essahib, Hilde Van de Velde, Maxine Scelwyn, M. Louise Hull, Beverley Vollenhoven, Luk J. Rombauts, Guiying Nie
Summary: This study found that PCX inhibits embryo implantation in vitro and in IVF patients. High levels of PCX significantly inhibited blastocyst attachment and penetration. The presence of PCX in the luminal epithelium was negatively associated with the success rate of clinical pregnancy.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Ching Hung Chen, Farn Lu, Wen Jui Yang, Pok Eric Yang, Wei Ming Chen, Shih Ting Kang, Yu Shan Huang, Yi Chi Kao, Chi Ting Feng, Po Chang Chang, Tiffany Wang, Chi An Hsieh, Yu Chun Lin, Jack Yu Jen Huang, Lily Hui-Ching Wang
Summary: The study identified predictor microRNAs in patients with repeated implantation failure (RIF) by analyzing miRNA profiles from the endometrium of patients undergoing in vitro fertilization (IVF). A signature set of miRNAs associated with the risk of RIF was identified, and a 3-miRNA signature was able to predict patients with RIF with an accuracy >90% in the validation cohort. The findings suggest that specific endometrial miRNAs can be used as diagnostic biomarkers to predict RIF and potentially increase the success rate of implantation practice.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Huishan Zhao, Lili Chen, Yinghua Shan, Gang Chen, Yongli Chu, Huangguan Dai, Xuemei Liu, Hongchu Bao
Summary: In this study, a ceRNA network was constructed based on differentially expressed circRNAs, miRNAs, and mRNAs in RIF. The hsa_circ_0038383-mediated miR196b-5p/HOXA9 axis was identified as a potential key pathway in affecting RIF. This network provides new insights for exploring potential biomarkers for diagnosis and clinical treatment of RIF.
Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Endocrinology & Metabolism
Junying Ma, Wenyan Gao, Da Li
Summary: Recurrent implantation failure (RIF) is a common problem in couples undergoing in vitro fertilization and embryo transfer. The lack of widely accepted definitions and treatment protocols hampers the progress in predicting and preventing RIF. The possible causes of RIF include immunology, thrombophilias, endometrial receptivity, microbiome, anatomical abnormalities, male factors, and embryo aneuploidy. Individualized treatment aimed at addressing the primary cause is crucial in increasing the implantation rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jing Zhao, Jie Hao, Bin Xu, Yanping Li
Summary: This study aimed to determine the proteomic differences in endometrial receptivity between recurrent implantation failure (RIF) and recurrent implantation success (RIS). The results showed that there were 625 differentially expressed proteins between RIF and RIS women, and these proteins were involved in various important signaling pathways related to embryo implantation.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
David Huang, Meagan Chan, Mary Solomon, Marcelle I. Cedars, Linda C. Giudice, Hakan Cakmak
Summary: The objective of this study was to determine the differential expression of B-cell lymphoma 6 (BCL6) in the window of implantation with different uterine preparation regimens for frozen embryo transfers. The results showed that BCL6 expression was lower in patients exposed to exogenous progesterone. Further investigation is needed to explore the validity and utility of BCL6 testing under medicated endometrial state.
FERTILITY AND STERILITY
(2023)
Article
Cell Biology
Jiaxing Li, Jia Qi, Guangxin Yao, Qinling Zhu, Xinyu Li, Rui Xu, Zhenyi Zhu, Hanting Zhao, Yuan Wang, Ying Ding, Yun Sun
Summary: SIRT1 plays a crucial role in regulating differentiation and maintaining ROS homeostasis of human ESCs during decidualization. Decreased expression of SIRT1 in RIF patients disrupts ROS balance, leading to inhibition of decidualization and reduced expression of decidual markers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.