Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

(2021) Katrine Z. Leth-Espensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

(2021) Pyry Helkkula et al.   PLoS Genetics

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

(2020) Kristian K. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids

(2020) Yan Q. Chen et al.   JOURNAL OF LIPID RESEARCH

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

(2020) Federico Oldoni et al.   JCI Insight

Angiopoietin-like protein 4(E40K) and ANGPTL4/8 complex have reduced, temperature-dependent LPL-inhibitory activity compared to ANGPTL4

(2020) Yan Q. Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity

(2019) Oleg Kovrov et al.   JOURNAL OF LIPID RESEARCH

Cholesteryl ester transfer protein and its inhibitors

(2018) Sudichhya Shrestha et al.   JOURNAL OF LIPID RESEARCH

Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition.

(2018) Aspen Gutgsell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

(2016) Ren Zhang   Open Biology

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

(2014) Gina M. Peloso et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Diabetic dyslipidemia

(2014) Liya Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of lipoprotein lipase by Angptl4

(2014) Wieneke Dijk et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

(2012) Gang Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

(2012) Ren Zhang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atypical angiopoietin-like protein that regulates ANGPTL3

(2012) F. Quagliarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

(2009) Wu Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk

(2008) Pascual DeSantis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY