Article
Endocrinology & Metabolism
Hao Jin, Haiyan Yang, Jiujia Zheng, Jiechun Zhou, Rong Yu
Summary: This study aimed to evaluate the distribution data of oocyte retrieval rate (ORR) in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and explore the risk factors for low ORR. The results showed that low estradiol levels/follicles (≥12 mm), progesterone levels, and the use of progestin-primed protocol were significant risk factors for low ORR.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fang Yang, Jin-Chun Lu, Tao Shen, Yi-Han Jin, Yuan-Jiao Liang
Summary: Hyperlipidemia may have adverse effects on the outcome of IVF in PCOS patients, increasing the dosage of gonadotropin and affecting embryo quality and endometrial receptivity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Haijie Gao, Xiaohui Lu, Hui Huang, Hong Ji, Ling Zhang, Zhiying Su
Summary: In PCOS patients, TSH levels, both in serum and follicular fluid, were negatively correlated with IVF oocyte maturation rate and fertilization rate, likely mediated by the TSHR/cAMP signaling pathway.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Xiaoying Zheng, Wei Guo, Lin Zeng, Danni Zheng, Shuo Yang, Yalan Xu, Lina Wang, Rui Wang, Ben Willem Mol, Rong Li, Jie Qiao
Summary: In infertile women with PCOS, one cycle of unstimulated IVM resulted in inferior cumulative live birth rates compared to one cycle of standard IVF, when using single vitrified-warmed blastocyst transfer.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Wei Guo, Yalan Xu, Tian Tian, Shuo Yang, Rong Li, Jie Qiao, Xiaoying Zheng
Summary: This study compared the impact of in vitro maturation (IVM) treatment on subsequent in vitro fertilization (IVF) cycles in women with polycystic ovary syndrome (PCOS). The results showed that even if the first IVM attempt failed, comparable cumulative live birth rates were observed in the subsequent IVF cycle. IVM treatment does not adversely affect the subsequent IVF cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Su Liu, Ling Hong, Meilan Mo, Shan Xiao, Xuejin Wang, Xinfeng Fan, Sainan Zhang, Lianghui Diao, Yong Zeng
Summary: This study investigated the relationship between antimullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) phenotypes, and whether AMH is associated with pregnancy outcomes in infertile women undergoing their first in vitro fertilization (IVF) treatment. The results showed that AMH is associated with PCOS severity and ovarian stimulation, but after controlling for other confounders, AMH is not associated with clinical pregnancy rate and live birth rate in women undergoing IVF.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Lin Zhang, Cao-Qing Yin, Shi-Jie Sun, Xue-Qin Teng, Dong-Yan Li, Jie Sun, Yuan-Yong Cui
Summary: Comprehensive nursing intervention for PCOS patients undergoing IVF significantly improves IVF and pregnancy outcomes, reducing negative emotions and potentially increasing the chances of successful IVF and improved pregnancy outcomes.
Article
Endocrinology & Metabolism
Haixia Jin, Xiaoxue Shen, Wenyan Song, Yan Liu, Lin Qi, Fuli Zhang
Summary: A nomogram was constructed to predict blastocyst formation rates for patients with different types of infertility based on clinical characteristics. The model performed well with acceptable calibration for each group of patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Heidi N. Boyda, Michelle Pham, Joyce Huang, Amanzo A. Ho, Ric M. Procyshyn, Jessica W. Y. Yuen, William G. Honer, Alasdair M. Barr
Summary: This study examined the role of peripheral catecholamines in antipsychotic-induced glucose intolerance and found a significant association between increased peripheral catecholamines and glucose intolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Reproductive Biology
Xin Li, Ting Luan, Yi Wei, Juan Zhang, JuanJuan Zhang, Chun Zhao, Xiufeng Ling
Summary: The study found a correlation between the systemic immune-inflammation index (SII) and assisted reproductive outcomes in patients with polycystic ovary syndrome (PCOS). Patients with higher SII had poorer clinical and laboratory outcomes during assisted reproductive procedures.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Chemistry, Analytical
Zina Fredj, Mohamad Sawan
Summary: Catecholamines are crucial neurotransmitters in the central nervous system and play key roles in neurological disorders. Optical and electrochemical biosensors have been widely adopted for the real-time monitoring of catecholamine neurotransmitters and their development has been greatly accelerated in the last decade. This review provides a comprehensive overview on the recent advances and main challenges in catecholamines biosensors, with emphasis on electrochemical biosensors and the unique characteristics brought by nanotechnology. It also summarizes the therapeutic use of nanomaterials for catecholamine analysis and future development trends based on specific biosensors' performance metrics.
Review
Biology
Lara Mastnak, Rok Herman, Simona Ferjan, Andrej Janez, Mojca Jensterle
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women, often accompanied by obesity and insulin resistance. Prolactin, traditionally associated with lactation and reproduction, has emerging roles in metabolic homeostasis. However, research on the relationship between PCOS, prolactin levels, and metabolism is limited and inconsistent.
Article
Developmental Biology
Alyssa Hochberg, Ginevra Mills, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H. Dahan
Summary: This study aimed to evaluate the histopathological patterns of placentas in pregnant women with polycystic ovary syndrome (PCOS) who underwent in-vitro fertilization (IVF). The findings showed that the placentas of PCOS women were more likely to have circumvallate placentas and hypercoiled umbilical cords.
Article
Obstetrics & Gynecology
Yavuz Emre Sukur, Batuhan Ozmen, Betul Yakistiran, Cem Somer Atabekoglu, Bulent Berker, Rusen Aytac, Murat Sonmezer
Summary: The study aimed to assess the impact of laparoscopic removal of endometrioma on assisted reproductive technology outcomes. Results showed that while surgery increased the risk of cycle cancellation due to poor ovarian response, it did not affect live birth rates.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Bulent Berker, Yavuz Emre Sukur, Eda Ureyen Ozdemir, Batuhan Ozmen, Murat Sonmezer, Cem Somer Atabekoglu, Rusen Aytac
Summary: The study found a significant association between the commencement time of hMG and live birth chance in ART cycles of POSEIDON group 3 and 4 poor responders. Early initiation of hMG together with rFSH seems to be beneficial in this specific population.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Ali Gokce, Yavuz Emre Sukur, Batuhan ozmen, Murat Sonmezer, Bulent Berker, Rusen Aytac, Cem Somer Atabekoglu
Summary: The study found a significant association between operative hysteroscopy prior to ART cycles and cervical insufficiency in the second trimester of pregnancy, indicating an increased risk of CI with preconception hysteroscopy. Further investigation with larger cohorts is needed to clarify this issue.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Murat Sonmezer, Cagri Gulumser, Meltem Sonmezer, Emre Sukur, Cem Atabekoglu
Summary: The study demonstrated that TUGOR is a feasible, effective, and safe method of oocyte retrieval, which is significant for patients who require fertility preservation or have inaccessible ovaries via the transvaginal route.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Seyma Osmanlioglu, Yavuz Emre Sukur, Vehbi Yavuz Tokgoz, Batuhan Ozmen, Murat Sonmezer, Bulent Berker, Rusen Aytac, Cem Somer Atabekoglu
Summary: Up to three cycles of IUI with ovarian stimulation can be an effective treatment modality in unexplained infertility, with significant clinical pregnancy and live birth rates. The duration of infertility was found to be shorter in women who successfully underwent IUI attempts.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Esra Yaprak, Yavuz Emre Sukur, Batuhan Ozmen, Murat Sonmezer, Bulent Berker, Cem Atabekoglu, Rusen Aytac
Summary: This study aimed to assess the effect of endometrial compaction on the live birth rate in frozen-thawed embryo transfer cycles and investigate the associated parameters. The results showed that in FET cycles with artificial endometrial preparation, cycles with endometrial compaction had a significantly higher live birth rate. An endometrial thickness of 9.25mm at the end of the oestrogen phase was predictive of endometrial compaction.
Article
Obstetrics & Gynecology
Batuhan Turgay, Yavuz Emre Sukur, Bulent Berker, Salih Taskin, Cem Atabekoglu, Batuhan Ozmen, Murat Sonmezer
Summary: The research found that previous abdominal surgery does not negatively impact the outcomes of total laparoscopic hysterectomy (TLH). It also showed that laparoscopic surgery is more beneficial for obese patients in terms of shorter hospital stays when compared to open surgery. Additionally, TLH may be associated with lower major complication rates.
JOURNAL OF GYNECOLOGIC SURGERY
(2021)
Article
Obstetrics & Gynecology
Bulut Varli, Yavuz Emre Sukur, Batuhan Ozmen, Berrin Imge Erguder, Murat Sonmezer, Bulent Berker, Cem Atabekoglu, Rusen Aytac
Summary: The study found that serum obestatin levels were significantly lower in PCOS patients, but did not affect the clinical pregnancy rate. Additionally, ovarian hyperstimulation syndrome (OHSS) was diagnosed only in PCOS patients, with lower obestatin levels in OHSS patients.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2021)
Article
Obstetrics & Gynecology
Gulsen Dogan Durdag, Gizem Bektas, Esengul Turkyilmaz, Halime Goktepe, Meltem Sonmezer, Yavuz Emre Sukur, Batuhan Ozmen, Cem Atabekoglu, Bulent Berker, Rusen Aytac, Murat Sonmezer
Summary: This study compared the efficacy of flexible protocols using dydrogesterone and GnRH antagonist in suppressing LH surge. Results showed longer pituitary suppression duration in the dydrogesterone group but higher risk of premature ovulation. Collected oocyte counts and metaphase II oocyte counts were similar between the groups.
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Yavuz Emre Sukur, Batuhan Aslan, Batuhan Ozmen, Murat Sonmezer, Bulent Berker, Cem Somer Atabekoglu, Rusen Aytac
Summary: This study assessed the impact of estrogen replacement therapy on frozen embryo transfer cycle outcomes. The results showed that a step-up 4-mg regimen provided a thicker endometrium and had a remarkable tendency to increase clinical pregnancy and live birth rates.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Koray Gorkem Sacinti, Yavuz Emre Sukur, Gizem Oruc, Batuhan Ozmen, Murat Sonmezer, Bulent Berker, Cem Somer Atabekoglu, Rusen Aytac
Summary: Following surgery for tubo-ovarian abscess, serum inflammatory markers increase in the early post-operative period and then decline with time. Normalization of white blood cell count is faster compared to C-reactive protein. White blood cell count and neutrophil to lymphocyte ratio measurements may be useful for follow-up and predicting the need for medical or surgical intervention.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Seyma Osmanlioglu, Bulent Berker, Batuhan Aslan, Yavuz Emre Sukur, Batuhan Ozmen, Murat Sonmezer, Cem Somer Atabekoglu, Rusen Aytac
Summary: This study aims to assess the impact of endometrioma on embryo quality and cycle outcome in patients with diminished ovarian reserve (DOR). The study found that although endometrioma may affect some parameters, the live birth rates of DOR patients are not affected.
REPRODUCTIVE SCIENCES
(2023)
Article
Genetics & Heredity
Meltem Sonmezer, Koray Gorkem Sacinti, Cagri Gulumser, Sinan Ozkavukcu, Cem Atabekoglu, Yavuz Emre Sukur, Murat Sonmezer
Summary: This study compared the feasibility, effectiveness, and safety of transabdominal ultrasound-guided oocyte retrieval (TUGOR) using a vaginal probe and traditional vaginal approach in virgin patients undergoing oocyte cryopreservation. The results showed no statistical differences between the two groups in terms of follicle count, oocyte collection, cryopreserved MII oocytes, procedure duration, stimulation duration, gonadotropin consumption, mature oocyte ratio, and follicle-oocyte index. Two cases of superficial epigastric artery injury occurred in the TUGOR group but resolved spontaneously within a few days.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Letter
Obstetrics & Gynecology
Koray Gorkem Sacinti, Gulsah Demirci, Murat Sonmezer, Hasan Serdar Ozturk
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sveta Aghayeva, Murat Sonmezer, Yavuz Emre Sukur, Aytaj Jafarzade
Summary: This study compared the effects of thyroid dysfunction, vitamin deficiency, and microelement deficiency in fertile and infertile patients, finding that infertile patients had significantly lower levels of folic acid, ferritin, and zinc than pregnant patients.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)
