Article
Medicine, Research & Experimental
Ke Wang, Yu-Bo Hu, Ye Zhao, Cong Ye
Summary: The study revealed that ASAP1-IT1 expression was downregulated in ovarian tumor samples and cells, with its overexpression inhibiting ovarian cancer cell proliferation and inducing apoptosis. ASAP1-IT1 plays a role in upregulating LATS2 expression, which in turn affects the expression of YAP1 in ovarian cancer cells. These findings suggest that ASAP1-IT1 functions as a potential tumor suppressor lncRNA in ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Yanping Liu, Chengguang Hu, Xiaoyong Qu, Honghui Chen, Logen Liu, Linlin Zhou, Side Liu, Guoqing Li, Yuanping Zhou
Summary: ASAP1-IT1 is significantly upregulated in hepatocellular carcinoma (HCC), and higher levels are associated with poorer prognosis. It is mainly localized in the nucleus of hepatoma cells and plays a critical role in cell proliferation and migration, potentially promoting proliferation and migration of HCC cells by interacting with miR-221-3p.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yantao Liu, Yuping Yang, Lingli Zhang, Jiaqiang Lin, Bin Li, Min Yang, Honghui Li, Kangwu Chen, Wei Zhao
Summary: The study revealed that ASAP1-IT1 promotes NSCLC progression by regulating cancer cell stemness, interacts with miR-509-3p, and influences the level of YAP1. Targeting this ASAP1-IT1/miR-509-3p signaling axis may be a promising therapeutic strategy to overcome NSCLC stemness.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hosub Park, Hwangkyu Son, Hyebin Cha, Kihyuk Song, Seongsik Bang, Seungyun Jee, Hyunsung Kim, Jaekyung Myung, Su-Jin Shin, Chihwan Cha, Min Sung Chung, Seungsam Paik
Summary: This study found that low ASAP1 expression was associated with worse recurrence-free survival in invasive breast cancer, particularly in ER-positive cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wangkai Xie, Zheng Han, Ziyi Zuo, Dong Xin, Hua Chen, Juanjuan Huang, Siyu Zhu, Han Lou, Zhiqiang Yu, Chenbin Chen, Sian Chen, Yuanbo Hu, Jingjing Huang, Fabiao Zhang, Zhonglin Ni, Xian Shen, Xiangyang Xue, Kezhi Lin
Summary: This study analyzed the relationship between differential expression of cytoskeleton genes and prognosis in gastric cancer (GC). ASAP1 was found to play a key role in cytoskeletal remodeling and prognosis in GC patients, and its overexpression can be used as a predictor of poor prognosis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shanyang He, Wei Wang, Zhiyong Wan, Hongwei Shen, Yunhe Zhao, Zeshan You, Jun Liu, Liwen Zhu
Summary: The study found that FAM83B inhibits ovarian cancer cisplatin resistance by suppressing the Wnt pathway, providing a new target for ovarian cancer therapy.
Article
Biochemistry & Molecular Biology
Xiao Yu, Pengfei Zhao, Qingyu Luo, Xiaowei Wu, Yating Wang, Yabing Nan, Shi Liu, Wenyan Gao, Bin Li, Zhihua Liu, Zhumei Cui
Summary: This study reveals that lncRNA RUNX1-IT1 plays a critical role in the progression of ovarian cancer. Its overexpression is associated with shorter survival and worse prognosis in patients. Knockdown of RUNX1-IT1 suppresses the proliferation, migration, and invasion of ovarian cancer cells and reduces metastasis formation. Mechanistically, RUNX1-IT1 regulates intracellular reactive oxygen homeostasis by altering histone modification status and activates NF-κB signaling. Targeting RUNX1-IT1 may be a promising therapeutic strategy for ovarian cancer treatment.
Article
Multidisciplinary Sciences
Subir Biswas, Gunjan Mandal, Kyle K. Payne, Carmen M. Anadon, Chandler D. Gatenbee, Ricardo A. Chaurio, Tara Lee Costich, Carlos Moran, Carly M. Harro, Kristen E. Rigolizzo, Jessica A. Mine, Jimena Trillo-Tinoco, Naoko Sasamoto, Kathryn L. Terry, Douglas Marchion, Andrea Buras, Robert M. Wenham, Xiaoqing Yu, Mary K. Townsend, Shelley S. Tworoger, Paulo C. Rodriguez, Alexander R. Anderson, Jose R. Conejo-Garcia
Summary: Most ovarian cancers are infiltrated by activated T cells that have prognostic relevance, but they show low response rates to immune checkpoint inhibitors. On the contrary, memory B cell and plasma cell infiltrates associated with better outcomes may exert protective effects against tumor cells through B cell-derived IgA in ovarian cancer.
Article
Nutrition & Dietetics
Luo Jiang, Ting-Ting Gong, Song Gao, Xiu-Qin Li, Fang-Hua Liu, Zhao-Yan Wen, Yi-Fan Wei, Shi Yan, Rui Hou, Qi-Jun Wu
Summary: Pre-diagnosis dairy product consumption, including protein, fat, and calcium intake, was associated with higher mortality among ovarian cancer survivors. Specific components of dairy intake such as protein, fat, and calcium were linked to increased mortality among patients.
FRONTIERS IN NUTRITION
(2021)
Article
Oncology
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Jongmin Sim, Yeseul Kim, Hosub Park, Jaekyung Myung, Hyunsung Kim, Seungsam Paik
Summary: High expression of ASAP1 in HCC patients is associated with aggressive clinicopathological characteristics and poor clinical outcomes, indicating ASAP1 as a prognostic biomarker in HCC patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Doris Mayr, Elisa Schmoeckel, Nina Ditsch
Summary: The study investigated the subcellular localization of thyroid hormone receptors (TRs) in ovarian cancer (OC) and its association with patient prognosis. The results showed that cytoplasmatic localization of TR beta was linked to shorter overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ryon P. Graf, Ramez Eskander, Leo Brueggeman, Dwayne G. Stupack
Summary: This study showed that a CNV-based risk score is independent of and superior to current or future genomic biomarkers for ovarian cancer in predicting overall survival. The identified CNV regions were not strongly associated with canonical ovarian cancer biological pathways, indicating potential candidates for future mechanistic investigations. External validation of the CNV risk score, especially in conjunction with more extensive clinical features, could be pursued through existing FDA-approved assays.
Article
Oncology
Se Ik Kim, Ji Hyun Kim, Sanghee Lee, Hyunsoon Cho, Willemien J. van Driel, Gabe S. Sonke, Robert E. Bristow, Sang-Yoon Park, Christina Fotopoulou, Myong Cheol Lim
Summary: This study systematically evaluated the value of hyperthermic intraperitoneal chemotherapy (HIPEC) in cytoreductive surgery (CRS) for epithelial ovarian cancer (EOC). The results showed that HIPEC improved progression-free survival (PFS) and overall survival (OS) in the recent chemotherapy exposure group, but had no significant effect in the non-recent chemotherapy exposure group.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Immunology
Songwei Feng, Yi Xu, Zhu Dai, Han Yin, Ke Zhang, Yang Shen
Summary: This study identified prognostic genes associated with cancer-associated fibroblasts (CAFs) in ovarian cancer patients. The researchers used bioinformatics analysis to identify CAF-associated hub genes and constructed a prognostic signature. The analysis indicated that high-risk patients have worse prognosis, weaker immune response, and lower tumor mutational burden (TMB) status but may be more sensitive to routine chemotherapeutic agents. The study suggests that the CAF-related signature may serve as a pretreatment guide for anti-CAFs and prognostic markers in CAFs could be potential therapeutic targets to inhibit ovarian cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim, Sang-Soo Seo
Summary: The study aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer by comparing differences between double primary cancer and metastatic cancer. Results showed that although patients with double primary cancer had longer overall survival, multivariate analysis did not identify any influential factors.
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for the quantification of ceramides in liver and small intestine tissues was developed and applied. The method demonstrated good sensitivity and linearity, as well as stable extraction recoveries and precision. The composition of ceramides in the two tissues provides insights for exploring biomarkers and molecular mechanisms of ceramide-related diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Review
Pharmacology & Pharmacy
Kenneth Chat Pan Cheung, Ma Jiao, Xingxuan Chen, Jia Wei
Summary: This article discusses the potential of extracellular vesicles in the treatment of osteoporosis, and introduces their characteristics and application prospects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Summary: In this study, the difference in fecal microbiome and bile acid (BA) profiles between low birth weight (LBW) and normal birth weight (NBW) piglets were investigated. Fecal microbiota transplantation confirmed the link between microbial BA metabolism and intestinal inflammation. The therapeutic potential of ursodeoxycholic acid (UDCA) was evaluated and it was found to alleviate intestinal inflammation through M2 macrophage polarization and suppression of inflammatory cytokines.
Article
Microbiology
Lepeng Zhou, Wen Qiu, Jie Wang, Aihua Zhao, Chuhui Zhou, Tao Sun, Ziyu Xiong, Peihua Cao, Wei Shen, Jingfen Chen, Xiaolu Lai, Liu-hong Zhao, Yue Wu, Meng Li, Feng Qiu, Yanhong Yu, Zhenjiang Zech Xu, Hongwei Zhou, Wei Jia, Yan Liao, Ravi Retnakaran, Daniel Krewski, Shi Wu Wen, Jose C. Clemente, Tianlu Chen, Ri-hua Xie, Yan He
Summary: The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related micro biome disturbances. In this study, VMT was found to be safe and had positive effects on infant neurodevelopment, gut microbiota maturation, and fecal metabolites.
CELL HOST & MICROBE
(2023)
Review
Immunology
Kenneth C. P. Cheung, Jiao Ma, Rodrigo Azevedo Loiola, Xingxuan Chen, Wei Jia
Summary: Bile acid-activated receptors have important roles in regulating microbiota-host immunity and may influence the development of metabolic disorders. This perspective provides a summary of regulatory pathways and mechanisms of these receptors, their impact on immune system, cell proliferation, and signaling in inflammatory diseases. It also discusses new therapeutic approaches and clinical projects on bile acids for disease treatment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Biochemistry & Molecular Biology
Claire L. K. Boulange, Helle K. Pedersen, Francois-Pierre Martin, Lea Siegwald, Albert Palleja C. Caro, Aron C. Eklund, Wei Jia, Huizhen Zhang, Bernard Berger, Norbert G. Sprenger, Ralf G. Heine, CINNAMON Study Investigator Grp
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siu Leung Chau, Aihua Zhao, Wei Jia, Lu Wang
Summary: This study presents a method for rapidly detecting pesticide residues and mycotoxins in Pu-erh tea. The results showed no pesticide residues and mycotoxins detected in the collected samples, all of which were below the legal limits.
Article
Oncology
Roberta Rosso, Marta D'Alonzo, Valentina Elisabetta Bounous, Silvia Actis, Isabella Cipullo, Elena Salerno, Nicoletta Biglia
Summary: This study analyzed the side effects of adjuvant endocrine therapy (AET) and their impact on treatment adherence. It found that side effects led to a 12% discontinuation rate, and trustful patient-physician communication and a good-quality care network could improve adherence to treatment.
Article
Oncology
Francesca Accomasso, Silvia Actis, Carola Minella, Roberta Rosso, Claudia Granaglia, Riccardo Ponzone, Nicoletta Biglia, Valentina Elisabetta Bounous
Summary: This study compares male and female breast cancer in terms of clinical and anatomopathological features, treatment approach, and survival outcomes. The findings suggest that male and female breast cancer have similar prognostic factors and survival outcomes, but there is a higher dropout rate in males for adjuvant endocrine therapy.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for quantifying ceramides and dihydroceramides in animal tissues has been developed. The results indicate significant differences in ceramide and dihydroceramide levels between liver and small intestine tissues, which may be related to the compositional features of ceramides.
ANALYTICAL BIOCHEMISTRY
(2023)
