Article
Hematology
Marcel Levi, Nick van Es
Summary: Cancer patients are more susceptible to severe COVID-19 infection due to the cancer itself or immune suppression from anti-cancer treatment. Severe COVID-19 infections often lead to coagulopathy, which is already a common complication in cancer patients. While COVID-19 vaccination appears to be safe and effective in most cancer patients, customized vaccination plans may be beneficial for increasing immune response. There is a need for specific management strategies to improve outcomes of cancer patients with COVID-19.
THROMBOSIS RESEARCH
(2022)
Article
Medicine, General & Internal
Federica Melazzini, Margherita Reduzzi, Silvana Quaglini, Federica Fumoso, Marco Vincenzo Lenti, Antonio Di Sabatino
Summary: This study aimed to assess the diagnostic delay of PE in COVID-19 patients and found a significant correlation between overall diagnostic delay and physician-related delay. Factors such as fever, respiratory symptoms, and high levels of lactate dehydrogenase were related to the delay in diagnosis.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Marcel Levi, Toshiaki Iba
Summary: Severe COVID-19 infections can lead to coagulopathy related to both venous and arterial thromboembolic disease, with characteristics that are similar but not identical to DIC. The virus's direct infection and damage to endothelial cells affect the coagulation response to COVID-19, potentially requiring separate diagnostic criteria for this distinct intravascular coagulation syndrome.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
D. El-Qutob, L. Alvarez-Arroyo, I Barreda, M. Nieto, M. Pin, Jose Luis Poveda-Andres, F. J. Carrera-Hueso
Summary: A considerable incidence of PE diagnosed by CTPA in SARS-CoV-2 infected patients has been observed, with no significant differences in age and sex between the infected and non-infected patients. The infected group had PE patients with a lower median age compared to those without PE. There were no differences in the diagnosis of PE and overall patient mortality between infected and non-infected patients in this study.
Review
Biochemistry & Molecular Biology
Cristian-Mihail Niculae, Adriana Hristea, Ruxandra Moroti
Summary: COVID-19 is often associated with pulmonary thrombotic events, especially in hospitalized patients, due to the proinflammatory state and disbalance in hemostasis caused by severe SARS-CoV-2 infection. Immune cells, cytokines, chemokines, and the complement system play key roles in immunothrombosis, damaging endothelial cells and inducing proinflammatory and procoagulant positive feedback loops. COVID-19-associated cytokine storm, platelets, red blood cells, and coagulation pathways contribute to the inflammation-endotheliopathy-thrombosis axis. The hypothesis of immunothrombosis is supported by imaging data showing peripheral blood clots associated with inflammatory lesions and the high incidence of thrombotic events despite routine thromboprophylaxis for venous thromboembolism.
Article
Respiratory System
Muhammad H. H. Gul, Zin Mar Htun, Vinicio de Jesus Perez, Muhammad Suleman, Samiullah Arshad, Muhammad Imran, Mahender Vyasabattu, Jeremy P. P. Wood, Michael Anstead, Peter E. E. Morris
Summary: This study aimed to investigate whether COVID-19 patients with pulmonary embolism had a higher mortality rate and assess the utility of d-dimer in predicting acute pulmonary embolism. The results showed that patients with acute pulmonary embolism had higher mortality and intubation rates. In addition, the increasing d-dimer value was associated with improved predictive performance for pulmonary embolism.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Antonin Trimaille, Anais Curtiaud, Kensuke Matsushita, Benjamin Marchandot, Jean-Jacques Von Hunolstein, Chisato Sato, Ian Leonard-Lorant, Laurent Sattler, Lelia Grunebaum, Mickael Ohana, Patrick Ohlmann, Laurence Jesel, Olivier Morel
Summary: Patients with APE in the setting of COVID-19 present with particular clinical-radiological and biological profiles, as well as a poor prognosis. The study emphasizes the significant role of inflammation and a prothrombotic state in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Virology
Anastasiya S. Babkina, Irina V. Ostrova, Mikhail Ya Yadgarov, Artem N. Kuzovlev, Andrey V. Grechko, Alexey V. Volkov, Arkady M. Golubev
Summary: Increased plasma levels of VWF in COVID-19 patients are associated with thrombus formation. Duration of disease and thrombotic complications are independent predictors of increased VWF immunostaining in pulmonary vessels. Additionally, bacterial pneumonia and lung ventilation are also associated with increased VWF staining.
Article
Biochemistry & Molecular Biology
Cristina Rodriguez, Neus Luque, Isabel Blanco, Laura Sebastian, Joan Albert Barbera, Victor Peinado, Olga Tura-Ceide
Summary: SARS-CoV-2, causing COVID-19, poses a major threat to global public health with severe respiratory and multiorgan complications. The complications of COVID-19, including cytokine storm and thrombi formation, involve the pulmonary endothelium in regulating vascular homeostasis and coagulation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Emergency Medicine
Jatin Narang, Amy S. Nowacki, Spencer S. Seballos, Philip R. Wang, Sharon E. Mace
Summary: This study aimed to determine whether D-dimer concentration can differentiate patients that require anti-coagulation from those who do not in the absence of imaging. Results showed that age-adjusted D-dimer cut-offs were effective in distinguishing these two groups of patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Health Care Sciences & Services
Carles Garcia-Cervera, Vicente Giner-Galvan, Philip Wikman-Jorgensen, Jaime Laureiro, Manuel Rubio-Rivas, Anthony Gurjian Arena, Francisco Arnalich-Fernandez, Jose Luis Beato Perez, Juan Antonio Vargas Nunez, Jesus Javier Gonzalez Igual, Jesus Diez-Manglano, Manuel Mendez Bailon, Maria Jose Garcia Blanco, Santiago J. Freire Castro, Judit Aranda Lobo, Luis Manzano, Jeffrey Oskar Magallanes Gamboa, Luis Arribas Perez, Julio Gonzalez Moraleja, Ruth Calderon Hernaiz, Javier Garcia Alegria, Amara Gonzalez Noya, Ricardo Gomez Huelgas, Carlos Lumbreras Bermejo, Juan Miguel Anton Santos
Summary: In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Emergency Medicine
Beatriz Valente Silva, Claudia Jorge, Rui Placido, Carlos Mendonca, Maria Luisa Urbano, Tiago Rodrigues, Joana Brito, Pedro Alves da Silva, Joana Rigueira, Fausto J. Pinto
Summary: This study compared several diagnostic methods for pulmonary embolism in COVID-19 patients and found that none of the current diagnostic prediction rules are reliable predictors of PE in this population. A D-dimer threshold of 500 ng/mL may be a more suitable screening test for PE in COVID-19 patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Geriatrics & Gerontology
An-tian Chen, Chen-yu Wang, Wen-ling Zhu, Wei Chen
Summary: COVID-19 is an age-related disease with a higher risk of organ dysfunction and mortality in older adults. Coagulation disorders and thrombosis are important pathophysiological changes in COVID-19 infection, with 95% of patients having coagulation disorders. Endothelial cell activation and dysfunction play a pivotal role in COVID-19 patients.
Article
Emergency Medicine
Mohsin Khan, Scott M. Alter, Lisa M. Clayton, Patrick G. Hughes, Richard D. Shih, Joshua J. Solano
Summary: The study aimed to compare the test characteristics of AADD measured in DDU with different cutoff values in geriatric patients suspected of PE, showing that AADD maintained sensitivity with improved specificity compared to standard cutoff. In this population, AADD could safely reduce imaging by 19% without missing any PEs, highlighting its value as a valid tool for ruling out PE in geriatric patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gazala Abdulaziz-Opiela, Anna Sobieraj, Greta Sibrecht, Julia Bajdor, Bartlomiej Mrozinski, Zuzanna Kozlowska, Rafal Iciek, Katarzyna Wroblewska-Seniuk, Ewa Wender-Ozegowska, Tomasz Szczapa
Summary: Neonatal venous thrombosis is a rare condition that can be caused by iatrogenic factors, viral infections, or genetic mutations. SARS-CoV-2 infections are also associated with thromboembolic complications, particularly in pediatric patients with MIS-C or MIS-N. This case report suggests a possible link between maternal SARS-CoV-2 infection and thromboembolic complications in the fetus or neonate. Further research is needed to evaluate the potential neonatal complications of maternal SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Simon Schalla, Mitch J. F. G. Ramaekers, Elham Bidar, Casper Mihl, Joachim E. Wildberger, Bouke P. Adriaans
Summary: Acute type A aortic dissection (ATAAD) is a life-threatening condition that requires emergency surgery. Patients should undergo regular imaging examinations to evaluate the occurrence of complications.
Article
Cardiac & Cardiovascular Systems
Hedwig M. J. M. Nies, Suzanne Gommers, Geertruida P. Bijvoet, Luuk I. B. Heckman, Frits W. Prinzen, Gaston Vogel, Caroline M. Van de Heyning, Amedeo Chiribiri, Joachim E. Wildberger, Casper Mihl, Robert J. Holtackers
Summary: This study evaluated the performance of various semi-automated techniques for quantifying myocardial infarct size using histopathology as the reference standard. The results showed that the signal threshold vs. reference mean method with a threshold of 5 standard deviations demonstrated the most accurate quantification in both conventional bright-blood and novel dark-blood late gadolinium enhancement (LGE) images.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Sibel Altintas, Samanta van Workum, Madeleine Kok, Ivo A. P. G. Joosen, Mathijs O. Versteylen, Patricia J. Nelemans, Joachim E. Wildberger, Harry J. G. M. Crijns, Marco Das, Bas L. J. H. Kietselaer
Summary: This study investigated the association between body mass index (BMI) and coronary artery calcification (CAC), and found no significant association after adjusting for other risk factors.
OBESITY SCIENCE & PRACTICE
(2023)
Review
Oncology
Lidewij M. F. H. Neeter, M. M. Quirien. Robbe, Thiemo J. A. van Nijnatten, Maxine S. Jochelson, H. P. J. Raat, Joachim E. Wildberger, Marjolein L. Smidt, Patty J. Nelemans, Marc B. I. Lobbes
Summary: This study compared the diagnostic accuracy of contrast-enhanced mammography (CEM) and standard contrast-enhanced breast magnetic resonance imaging (breast MRI). The results showed that both CEM and breast MRI had high sensitivity and moderate specificity in detecting breast tumors, and the overall diagnostic performance of breast MRI was better than CEM. However, current scientific evidence is insufficient to prematurely consider CEM as an alternative to breast MRI.
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Joachim E. Wildberger, Thomas Flohr, Hatem Alkadhi
Summary: Since the 1970s, X-ray CT has become a significant diagnostic imaging technology in modern medicine, thanks to technological advances improving image quality and diagnostic value. Photon-counting detector (PCD)-CT, a novel technology, has emerged with the potential to overcome limitations of current CT systems and offer improved capabilities. This review summarizes the first clinical experience of PCD-CT, focusing on recent prototypes and clinically approved systems, presenting initial publications and corresponding clinical cases.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Cas J. Fuchs, Remco Kuipers, Jan A. Rombouts, Kim Brouwers, Vera B. Schrauwen-Hinderling, Joachim E. Wildberger, Lex B. Verdijk, Luc J. C. van Loon
Summary: This study assessed the differences in muscle group volumes between young and older males and found that the most significant differences were observed in the thigh muscle group, with the quadriceps femoris showing the largest difference in muscle volume between young and older men. Overall, young men have larger muscle volumes compared to older men.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael C. Mcdermott, Babs M. F. Hendriks, Joachim E. Wildberger, Sanne W. de Boer
Summary: Manual dilution of contrast media in endovascular procedures can result in inaccurate and uneven concentration, leading to incorrect reporting of administered doses to patients.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Hematology
Katherine J. Kearney, Henri M. H. Spronk, Jonas Emsley, Nigel S. Key, Helen Philippou
Summary: It was previously believed that plasma kallikrein (PKa) only functioned to activate factor XII (FXII) in the coagulation cascade. However, recent studies have revealed a new pathway where PKa can directly activate factor IX (FIX). These studies identified the binding of FIX/FIXa with PK/PKa, the PKa-induced thrombin generation and clot formation independent of FXI, and the increased formation of FIXa:AT complexes due to PKa activity. The existence of both a canonical (FXIa-dependent) and non-canonical (PKa-dependent) pathway of FIX activation is suggested.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc B. I. Lobbes, Lidewij M. F. H. Neeter, Frank Raat, Kim Turk, Joachim E. Wildberger, Thiemo J. A. van Nijnatten, Patricia J. Nelemans
Summary: Breast MRI is considered the best modality for preoperative staging of invasive lobular carcinoma (ILC). However, evidence of the accuracy of contrast-enhanced mammography (CEM) in women diagnosed with ILC is limited. This study aimed to retrospectively evaluate the accuracy of CEM and MRI in preoperative staging of ILC.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamed Kassem, Kelly P. H. Nies, Ellen Boswijk, Jochem van der Pol, Mueez Aizaz, Marion J. J. Gijbels, Debiao Li, Jan Bucerius, Werner H. Mess, Joachim E. Wildberger, Robert J. van Oostenbrugge, Rik P. M. Moonen, Zhaoyang Fan, M. Eline Kooi
Summary: This study compares the quantification of plaque composition with MATCH and multi-sequence MRI. The results show that MATCH can effectively quantify LRNC and IPH, but is not effective for calcifications. MATCH has the advantage of shorter scan time and inherent co-registration, despite lower image quality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Jos J. M. Westenberg, Bouke P. Adriaans, Estelle C. Nijssen, Joachim E. Wildberger, Hildo J. Lamb, Simon Schalla
Summary: Four-dimensional flow magnetic resonance imaging is a promising technique for diagnosing and stratifying the risk of aortic disease. This review aims to provide clinicians with a guide to the basics of flow imaging, commonly used flow-related parameters, and their relevance in the context of aortic disease.
INSIGHTS INTO IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Berta H. Ganizada, Koen D. Reesink, Shaiv Parikh, Mitch J. F. G. Ramaekers, Asim C. Akbulut, Pepijn J. M. H. Saraber, Gijs P. Debeij, Ehsan MUMC TAA Student Team, Armand M. Jaminon, Ehsan Natour, Roberto Lorusso, Joachim E. Wildberger, Barend Mees, Geert Willem Schurink, Michael J. Jacobs, Jack Cleutjens, Ingrid Krapels, Alexander Gombert, Jos G. Maessen, Ryan Accord, Tammo Delhaas, Simon Schalla, Leon J. Schurgers, Elham Bidar
Summary: Current management guidelines for ascending thoracic aortic aneurysms (aTAA) suggest intervention once the diameter reaches 5-5.5 cm or shows a growth rate of >0.5 cm/year. However, aTAA dissections (aTAAD) often occur in vessels with diameters below the surgical intervention threshold. To improve understanding of aTAA pathophysiology, the MAPEX platform focuses on the interactions between vascular smooth muscle cells and extracellular matrix, aiming to narrow knowledge gaps and improve diagnostic and prognostic possibilities.
Review
Cardiac & Cardiovascular Systems
Constance C. F. M. J. Baaten, Magdolna Nagy, Wolfgang Bergmeier, Henri M. H. Spronk, Paola E. J. van der Meijden
Summary: Coronary atherosclerosis is the leading cause of heart disease in developed countries and is a chronic inflammatory process. The composition and location of atherosclerotic plaques determine the phenotype of the lesion, and plaque rupture or erosion can lead to acute clinical events. The contribution of platelets to thrombus formation differs depending on the plaque phenotype.
EUROPEAN HEART JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. C. Nijssen, P. J. Nelemans, R. J. Rennenberg, G. van Ommen, J. E. Wildberger
Summary: According to the latest ESUR contrast media guidelines, standard prophylaxis is no longer recommended for patients with moderate chronic kidney disease (CKD). The guideline updates are based on indirect evidence and expert opinion, as there is limited direct evidence supporting the withdrawal of standard prophylaxis in moderate CKD patients. The updated guideline recommendation has shown substantial benefits for patients and hospitals in terms of burden reduction.
EUROPEAN RADIOLOGY
(2023)