High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo

Mitochondrial functional resilience after TFAM ablation in the adult heart

(2021) Nasab Ghazal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication

(2021) Min Jiang et al.   Science Advances

Mitochondrial Diseases: Hope for the Future

(2020) Oliver M. Russell et al.   CELL

Mitochondrial disease in children

(2020) S. Rahman   JOURNAL OF INTERNAL MEDICINE

Primary Role of the Nucleosome

(2020) Roger D. Kornberg et al.   MOLECULAR CELL

Mitochondrial DNA copy number in human disease: the more the better?

(2020) Roberta Filograna et al.   FEBS LETTERS

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Recent advances in understanding the molecular genetic basis of mitochondrial disease

(2019) Kyle Thompson et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

(2019) R. Filograna et al.   Science Advances

Mitochondrial fusion is required for regulation of mitochondrial DNA replication

(2019) Eduardo Silva Ramos et al.   PLoS Genetics

Live-cell STED nanoscopy of mitochondrial cristae

(2019) Till Stephan et al.   Scientific Reports

MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition

(2019) Jakob D. Busch et al.   Cell Reports

SnapShot: Mitochondrial Nucleoid

(2018) Nina A. Bonekamp et al.   CELL

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

(2018) Thomas J. Nicholls et al.   MOLECULAR CELL

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

(2018) Johanna H K Kauppila et al.   NUCLEIC ACIDS RESEARCH

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

(2018) Stanka Matic et al.   Nature Communications

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Maintenance and Expression of Mammalian Mitochondrial DNA

(2016) Claes M. Gustafsson et al.   Annual Review of Biochemistry

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

(2015) Christian Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and Transcription

(2014) Géraldine Farge et al.   Cell Reports

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

(2012) Lloye M. Dillon et al.   HUMAN MOLECULAR GENETICS

Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice

(2012) Nobutoshi Morimoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

(2012) Bin Lu et al.   MOLECULAR CELL

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

(2012) Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

(2011) T. A. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of human mitochondrial RNA polymerase

(2011) Rieke Ringel et al.   NATURE

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

(2011) Anna Rubio-Cosials et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

(2011) Huu B Ngo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system

(2010) Satoshi Nishiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High mitochondrial DNA copy number has detrimental effects in mice

(2010) Emil Ylikallio et al.   HUMAN MOLECULAR GENETICS

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

(2010) Javier Miralles Fusté et al.   MOLECULAR CELL

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

(2010) Masaaki Hokari et al.   NEUROPATHOLOGY

Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

(2010) Y. Matsushima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Phos-tag SDS-PAGE under neutral pH conditions for advanced protein phosphorylation profiling

(2010) Eiji Kinoshita et al.   PROTEOMICS

Mitochondrial nucleoids undergo remodeling in response to metabolic cues

(2008) M. Kucej et al.   JOURNAL OF CELL SCIENCE

Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice

(2008) Y. Hayashi et al.   JOURNAL OF NEUROSCIENCE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

(2008) S. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA