Article
Biochemistry & Molecular Biology
Jae Yoon An, Wooram Um, Dong Gil You, Yeari Song, Jeongjin Lee, Nguyen Van Quy, Hyeyeon Joo, Jueun Jeon, Jae Hyung Park
Summary: A novel hyaluronic acid hydrogel-based depot with ultrasound-triggered thermal elevation and on-demand cargo release for cancer therapy was reported in this study. The results demonstrated that the hydrogel significantly increased temperature and released cargo under ultrasound, showing potential for in vivo applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Yuning Luo, Junyan Tan, Yue Zhou, Yuqiong Guo, Xinying Liao, Li He, Dingxilei Li, Xinxin Li, Yang Liu
Summary: Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and moisturizing effect, which can affect angiogenesis, inflammation, and cell behavior. HA-based hydrogels formed by physical or chemical crosslinking strategies have both the physiological function of HA and the skeleton function of hydrogel. However, natural HA-based hydrogels have limitations such as insufficient mechanical strength and susceptibility to degradation. Researchers have developed various HA-based multifunctional hydrogels with notable properties by modifying the structure, using novel crosslinking strategies, and introducing reactive molecules. These hydrogels have extended the application scope in anticancer drug delivery, cartilage repair, three-dimensional cell culture, skin dressing, and other fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Pengcheng Zhang, Weijia Yan, Hong Yan
Summary: The changes in vitreous body after vitreous hemorrhage were observed in this study. It was found that the changes were relatively minor earlier (2-4 weeks), but irreversible later. Specifically, the degree of liquefaction increased with a decrease in viscosity, and the chemotaxis of macrophages and bFGF induction led to incomplete posterior vitreous detachment.
Article
Biochemistry & Molecular Biology
Sheida Jahanbekam, Negin Mozafari, Azar Bagheri-Alamooti, Soliman Mohammadi-Samani, Saeid Daneshamouz, Reza Heidari, Negar Azarpira, Hajar Ashrafi, Amir Azadi
Summary: An injectable thermo-ultrasound-triggered drug carrier based on Pluronic® F-127, hyaluronic acid, and gelatin was designed for the treatment of arthritis. The thermo-responsive hydrogel showed a prolonged drug release and improved the disease status in an animal model. This study highlights the potential of ultrasound-responsive in situ-forming hydrogels for efficient treatment of arthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Shuqin Yu, Shuo Wang, Lixin Xia, Huiwen Hu, Mingyu Zou, Zhiwen Jiang, Jinhua Chi, Yijie Zhang, Hongjian Li, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: A study has successfully prepared a thiolated hyaluronic acid (SH-HA) hydrogel as a vitreous substitute, which demonstrated excellent biocompatibility and intraocular compatibility in experimental rabbits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sheila Maiz-Fernandez, Nagore Barroso, Leyre Perez-Alvarez, Unai Silvan, Jose Luis Vilas-Vilela, Senentxu Lanceros-Mendez
Summary: This study evaluates the various properties of HA/CHI polycomplex hydrogels and optimizes their synthesis parameters, demonstrating their potential in advanced biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Simona Serini, Roberta Cassano, Matilde Bruni, Camilla Servidio, Gabriella Calviello, Sonia Trombino
Summary: A hyaluronic acid- and folic acid-based hydrogel (GEL-CIS) was successfully prepared and characterized for the delivery of cisplatin, which showed improved efficacy in inhibiting ovarian cancer cell growth and migration compared to pure cisplatin, as well as modulating the expression of proteins involved in Epithelial Mesenchymal Transition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Otorhinolaryngology
Hiromi Nagai, Koichiro Nishiyama, Yutomo Seino, Yasuhiko Tabata, Taku Yamashita
Summary: In an animal experiment study, it was found that implanting bFGF and autologous fascia in lateral thyroarytenoid muscle can improve severe laryngeal paralysis. This treatment showed histologic improvement by reconstructing the vascular network, suggesting that the decrease in muscle mass after paralysis can be countered. Other treated groups did not show significant effects in comparison to the untreated group.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Yu Fang, Lele Shi, Zhiwei Duan, Saeed Rohani
Summary: Stem cell-based therapies have great potential for organ repair, but actual outcomes are disappointing. Hyaluronic acid-based hydrogels show promise for stem cell delivery, but differentiation process is easily influenced. Hyaluronic acid holds broad prospects in stem cell delivery and fate control.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Mario Saletti, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto Giacometti Schieroni, Agnese Magnani, Andrea Cappelli
Summary: An easy and viable crosslinking procedure using click-chemistry was developed for hyaluronic acid. The resulting crosslinked materials showed no cytotoxic effects, tunable water affinity, and rheological properties, suggesting potential applications in different biomedical fields.
Article
Chemistry, Applied
Xin Li, Xueyu Tang, Meijuan Chen, Peng Wang, Liang Liu, Junhua Zhang, Yimin Fan
Summary: An implantable and in-vivo shape-recoverable hydrogel based on hyaluronic acid (HA) has been developed for tissue filling. It is formed by hydrogen bonding between HA and TEMPO-oxidation cellulose nano-fiber, and has good shaping ability and biocompatibility.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Anna Szarpak, Rachel Auzely-Velty
Summary: In this study, a simple method is demonstrated to prepare a hyaluronic acid (HA) single-network hydrogel that is stretchable and highly elastic without the need for additional components or complicated processes. The hydrogel is formed by densely entangled HA chains tied together by a small number of covalent bonds. The presence of covalent cross-links prevents disintegration of the HA network, while entanglements provide high stretchability. The hydrogel shows negligible hysteresis and perfect recovery after stretching-relaxation cycles.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Penghui Fan, Qi Dong, Junfeng Yang, Yun Chen, Hongjun Yang, Shaojin Gu, Weilin Xu, Yingshan Zhou
Summary: A flexible hyaluronic acid hydrogel adhesive with rapid gelation and strong tissue adhesion properties was fabricated via photopolymerization. The introduction of acrylate groups and high substitution of catechol groups enhanced its adhesive and procoagulant properties. The hydrogel exhibited superior hemostatic performance and biocompatibility compared to commercial products.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Kasra Goodarzi, Rachel Lane, Shreyas S. Rao
Summary: This study investigates the impact of biochemical cues on dormancy and proliferation in brain metastatic breast cancer cells using hyaluronic acid (HA) hydrogels as a biomimetic platform. The results demonstrate that biochemical cues influence cell morphology, cell spreading area, and cell proliferation. The study also reveals that dormancy in these cells is regulated by biochemical cues and is reversible. Furthermore, the involvement of beta 1 integrin in mediating cell phenotype in the hydrogel platform is demonstrated. These findings provide insight into the role of biochemical cues in the biology of brain metastatic breast cancer cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Lijie Huang, Junjie Wang, Lili Kong, Xing Wang, Qiulei Li, Lingjiao Zhang, Jingru Shi, Jinyou Duan, Haibo Mu
Summary: Probiotics are commonly used in inflammatory bowel disease, but their effectiveness is limited by low survival rate and short retention time. To address this issue, researchers developed a ROS-responsive hydrogel based on hyaluronic acid for encapsulation and targeted delivery of probiotics. The hydrogel improved the survival rate of encapsulated probiotics in simulated digestive conditions and selectively released them at inflammation sites. Animal experiments showed that hydrogel-encapsulated probiotics significantly alleviated symptoms and improved survival rate in mice with colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Pegah Rahimizadeh, Tohid Rezaei Topraggaleh, Mohammad Hossein Nasr-Esfahani, Niloofar Ziarati, Shahab Mirshahvaladi, Vahid Esmaeili, Soroush Seifi, Poopak Eftekhari-Yazdi, Abdolhossein Shahverdi
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2020)
Article
Cell Biology
Samaneh Faraji, Leila Rashki Ghaleno, Mohsen Sharafi, Maryam Hezavehei, Mehdi Totonchi, Abdolhossein Shahverdi, Rouhollah Fathi
Summary: The study evaluated the effects of cryopreservation on the expressions of SPAG genes in human sperm, finding a decrease in the expression of certain SPAG genes during freezing. This suggests that the freezing procedure could negatively affect gene expression in human spermatozoa.
BIOPRESERVATION AND BIOBANKING
(2021)
Article
Anatomy & Morphology
Mohammad Rabiei, Naser Kalhor, Aisan Farhadi, Sorour Ramezanpour, Yaser Tahamtani, Mahnaz Azarnia
Summary: Despite the availability of efficient pharmaceuticals for diabetes management, new drugs are needed to preserve and restore the function of pancreatic beta-cells. In this study, small molecules with potential anti-diabetic activity were tested using an in vitro screening model. Some of these molecules were found to increase the expression of genes related to insulin production and secretion, providing potential opportunities for diabetes intervention.
CELLS TISSUES ORGANS
(2023)
Article
Cell Biology
Maryam Jazayeri, Poopak Eftekhari-Yazdi, Mohammad Ali Sadighi Gilani, Mohsen Sharafi, Abdolhossein Shahverdi
Summary: High rates of infertility in type 2 diabetic men have led to attempts to understand the mechanisms involved. This study found that T2DM alters the methylation profile and epigenetic programming in spermatozoa of humans and may ultimately influence the fertility status of men with diabetes.
Article
Andrology
Vahid Esmaeili, Morteza Zendehdel, Abdolhossein Shahverdi, AliReza Alizadeh
Summary: Obesity is associated with male infertility, and little is known about the relationship between obesity-related markers and sperm parameters. This study found that obese men had higher waist circumference, hip circumference, waist to hip ratio, body fat mass, skeletal muscle, resting metabolism, and visceral fat compared to normal-weight and overweight men. In normal-weight men, body fat mass and visceral adiposity index were positively correlated with sperm progressive motility. In obese men, sperm progressive motility was positively correlated with height and negatively correlated with waist to hip ratio. The study also found that the association between serum testosterone levels, testosterone/estradiol ratios, and semen parameters depended on obesity-related markers.
Article
Geriatrics & Gerontology
Fariba Nosrati, Johannes Grillari, Mahnaz Azarnia, Mohammad Nabiuni, Reza Moghadasali, Latifeh Karimzadeh, Ingo Laemmermann
Summary: Tissue fibrosis is a common issue in organ aging, caused by the chronic accumulation of senescent cells. Fibroblasts, especially in the skin, play a crucial role in fibrosis by proliferating and depositing excessive extracellular matrix (ECM). This study aims to investigate the influence of senescent fibroblasts and their secretome on dermal fibrosis. The results show that senescent fibroblasts have the potential to be profibrotic, but their secretome failed to induce a fibrotic response in non-senescent cells, contrary to studies on lung fibroblasts.
Review
Agriculture, Dairy & Animal Science
Mohsen Sharafi, Seyyed Mohsen Borghei-Rad, Maryam Hezavehei, Abdolhossein Shahverdi, James D. Benson
Summary: This comprehensive review examines the mechanisms of damage caused by cryopreservation and highlights classical and novel strategies to reduce this damage and improve sperm survival. Cryopreservation is an important method for preserving germplasm in various fields, but the current methods only yield about 50% viable spermatozoa after cryopreservation. Various sperm components, including the plasma membrane, nucleus, mitochondria, proteins, mRNAs, and microRNAs, can be damaged during the process. Conventional strategies using chemical additives have been employed, but they are not completely effective in preventing damage.
Article
Cell Biology
Shahab Mirshahvaladi, Tohid Rezaei Topraggaleh, Mustafa Numan Bucak, Pegah Rahimizadeh, Abdolhossein Shahverdi
Summary: Asthenozoospermia, characterized by low sperm motility, is a common cause of male infertility. This study identified and quantified a total of 2140 proteins in the sperm tails of asthenozoospermic patients and controls, with 409 differentially expressed proteins. Bioinformatics analysis further revealed alterations in mitochondrial energy production, stress response, and other biological processes in asthenozoospermic sperm tails.
CELL AND TISSUE RESEARCH
(2023)
Article
Cell Biology
Davood Zaeifi, Mahnaz Azarnia
Summary: The study focuses on efficiently transdifferentiating rat bone marrow-derived mesenchymal stem cells (BM-MSCs) into islet-like cells and encapsulating and transplanting them for the treatment of T1DM. High glucose concentration combined with specific factors is used to induce the transdifferentiation. Encapsulated beta-cells show enhanced viability and functionality, leading to significant reduction of glucose levels in diabetic rats.
CELL AND TISSUE RESEARCH
(2023)
Article
Andrology
Parisa Yazdanpanah Ghadikolaei, Leila Rashki Ghaleno, Samira Vesali, Ehsan Janzamin, Mohammad Ali Sadighi Gilani, Hesamoddin Sajadi, Ahmad Vosough Taghi Dizaj, Abdolhossein Shahverdi, Joel R. Drevet, AliReza Alizadeh Moghadam Masouleh
Summary: This study analyzed nearly 1200 sperm samples to evaluate the sperm DNA fragmentation index and its association with factors such as age, body mass index, season of sperm collection, geographical location, medical history, and addictive behaviors. The results showed that the sperm DNA fragmentation index increased with age, was higher in spring and summer samples, was not correlated with body mass index, and was higher in rural and epileptic patients. Overall, age was found to be the strongest factor associated with the sperm DNA fragmentation index.
Article
Medicine, General & Internal
Sima Mashayekh, Mahnaz Azarnia, Esmail Fattahi, Reza Moghadasali
Summary: In this study, it was found that flavonoid compounds derived from walnut green skin could effectively induce the differentiation of adipose tissue-derived mesenchymal stem cells (AD-MSCs) into insulin-producing cells.
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Hadi Zeinali, Mahnaz Azarnia, Peyman Keyhanvar, Reza Moghadasali, Somayeh Ebrahimi-Barough, Majid Marandi-Kouchaki
Summary: Human endometrial stromal/stem cells (hEnSCs) show promising potential in the treatment of cisplatin-induced acute kidney injury (AKI) due to their anti-inflammatory and immunomodulatory effects, as well as their ability to enhance cell proliferation.
Article
Cell Biology
Hadis Zeinali, Mahnaz Azarnia, Peyman Keyhanvar, Reza Moghadasali, Somayeh Ebrahimi-Barough
Summary: The study investigated the effects of hEnSCs on cisplatin-induced AKI and found that hEnSCs injection may improve AKI through reducing apoptosis in renal cells.
Article
Pharmacology & Pharmacy
Fatemeh Kamalipour, Hanieh Jalali, Mahnaz Azarnia
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Atefeh Hemati, Mohammad Hossein Modarressi, Sedighe Kolivand, Mahnaz Azarnia
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)
