When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells

Processive RNA polymerization and promoter recognition in an RNA World

(2021) Razvan Cojocaru et al.   SCIENCE

Prebiotic Syntheses of Noncanonical Nucleosides and Nucleotides

(2020) David M. Fialho et al.   CHEMICAL REVIEWS

Autocatalytic chemical networks at the origin of metabolism

(2020) Joana C. Xavier et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nonenzymatic Metabolic Reactions and Life’s Origins

(2020) Kamila B. Muchowska et al.   CHEMICAL REVIEWS

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids

(2020) R. Trent Stubbs et al.   Nature Chemistry

Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry

(2018) Raghav R. Poudyal et al.   BIOCHEMISTRY

Copying of Mixed-Sequence RNA Templates inside Model Protocells

(2018) Derek K. O’Flaherty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid vesicles chaperone an encapsulated RNA aptamer

(2018) Ranajay Saha et al.   Nature Communications

Ribozyme-catalysed RNA synthesis using triplet building blocks

(2018) James Attwater et al.   eLife

Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

(2018) Travis Walton et al.   BIOCHEMISTRY

Chemical Evolution and the Evolutionary Definition of Life

(2017) Paul G. Higgs   JOURNAL OF MOLECULAR EVOLUTION

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

(2017) Shaun Stairs et al.   Nature Communications

Prebiotic Systems Chemistry: Complexity Overcoming Clutter

(2017) Saidul Islam et al.   Chem

Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution

(2017) Gabriel Piedrafita et al.   Scientific Reports

The origin and spread of a cooperative replicase in a prebiotic chemical system

(2015) Julie A. Shay et al.   JOURNAL OF THEORETICAL BIOLOGY

A recursive vesicle-based model protocell with a primitive model cell cycle

(2015) Kensuke Kurihara et al.   Nature Communications

Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean

(2014) M. A. Keller et al.   Molecular Systems Biology

Modelling Lipid Competition Dynamics in Heterogeneous Protocell Populations

(2014) Ben Shirt-Ediss et al.   Scientific Reports

Autocatalytic Replication and Homochirality in Biopolymers: Is Homochirality a Requirement of Life or a Result of It?

(2012) Meng Wu et al.   ASTROBIOLOGY

The origin of life is a spatially localized stochastic transition

(2012) Meng Wu et al.   Biology Direct

Theoretical conditions for the stationary reproduction of model protocells

(2012) Fabio Mavelli et al.   Integrative Biology

Cascade of Reduced Speed and Accuracy after Errors in Enzyme-Free Copying of Nucleic Acid Sequences

(2012) Kevin Leu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Size matters: Influence of stochasticity on the self-maintenance of a simple model of metabolic closure

(2012) Gabriel Piedrafita et al.   JOURNAL OF THEORETICAL BIOLOGY

The Importance of Stochastic Transitions for the Origin of Life

(2012) Paul G Higgs et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach

(2012) Gabriel Piedrafita et al.   PLoS One

The Origins of Nucleotides

(2011) Matthew Powner et al.   SYNLETT

Lack of evolvability in self-sustaining autocatalytic networks constraints metabolism-first scenarios for the origin of life

(2010) V. Vasas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins of Cellular Life

(2010) J. P. Schrum et al.   Cold Spring Harbor Perspectives in Biology

A Simple Self-Maintaining Metabolic System: Robustness, Autocatalysis, Bistability

(2010) Gabriel Piedrafita et al.   PLoS Computational Biology

Origin of Self-Replicating Biopolymers: Autocatalytic Feedback Can Jump-Start the RNA World

(2009) Meng Wu et al.   JOURNAL OF MOLECULAR EVOLUTION

Coupled Growth and Division of Model Protocell Membranes

(2009) Ting F. Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY