Journal
GREEN CHEMISTRY
Volume 18, Issue 14, Pages 3990-3996Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6gc00932h
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Funding
- Eastman Chemical Company
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Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU Substances of Very High Concern list. Accordingly there is an urgent need for nontoxic alternatives to the dipolar aprotic solvents. N-Butylpyrrolidinone, although structurally similar to NMP, is not mutagenic or reprotoxic, yet retains many of the characteristics of a dipolar aprotic solvent. This work introduces N-butylpyrrolidinone as a new solvent for cross-coupling reactions and other syntheses typically requiring a conventional dipolar aprotic solvent.
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