Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi

Anti-Trypanosoma cruzi Activity of Metabolism Modifier Compounds

(2021) Nieves Martinez-Peinado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells

(2021) Álvaro Lorente‐Macías et al.   ARCHIV DER PHARMAZIE

Emerging agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?

(2020) Nieves Martínez-Peinado et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

β-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth

(2020) Thomas Cheviet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity

(2020) Nieves Martinez-Peinado et al.   Parasites & Vectors

Energy blackout against glycolytic parasites

(2020) Alba Martínez-Flórez et al.   International Journal for Parasitology-Drugs and Drug Resistance

Triazole derivatives and their antiplasmodial and antimalarial activities

(2019) Xue-Mei Chu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues

(2019) Thomas Cheviet et al.   JOURNAL OF MEDICINAL CHEMISTRY

New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations

(2018) Débora Inácio Leite et al.   Chemical Biology & Drug Design

Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis

(2018) Clara Crespillo-Andújar et al.   DRUG SAFETY

Searching for new drugs for Chagas diseases: triazole analogs display high in vitro activity against Trypanosoma cruzi and low toxicity toward mammalian cells

(2018) Robson Xavier Faria et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

1 H and 13 C assignments of 6-, 8-, 9- substituted purines

(2018) Álvaro Lorente-Macías et al.   MAGNETIC RESONANCE IN CHEMISTRY

Synthesis and antiplasmodial activity of purine-based C-nucleoside analogues

(2018) Kartikey Singh et al.   MedChemComm

Discovery of novel 7-aryl 7-deazapurine 3’-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

(2018) Fabian Hulpia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

(2017) Benjamin Blasco et al.   NATURE MEDICINE

Database resources of the National Center for Biotechnology Information

(2017) et al.   NUCLEIC ACIDS RESEARCH

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

A systematic analysis of atomic protein–ligand interactions in the PDB

(2017) Renato Ferreira de Freitas et al.   MedChemComm

Immucillins in Infectious Diseases

(2017) Gary B. Evans et al.   ACS Infectious Diseases

Global Epidemiology of Plasmodium vivax

(2016) Rosalind E. Howes et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Safety Profile of Nifurtimox for Treatment of Chagas Disease in the United States

(2016) Colin J. Forsyth et al.   CLINICAL INFECTIOUS DISEASES

Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors

(2015) Maria J. Pineda de las Infantas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity

(2015) Maria J. Pineda de las Infantas y Villatoro et al.   Scientific Reports

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics

(2014) Jong Min Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

(2011) Marcela Krečmerová et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

(2011) María B. Cassera et al.   PLoS One

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

Chagas disease in Spain, the United States and other non-endemic countries

(2009) Joaquim Gascon et al.   ACTA TROPICA

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

(2009) Esther Bettiol et al.   PLoS Neglected Tropical Diseases

Purine Salvage Pathways in the Intraerythrocytic Malaria ParasitePlasmodium falciparum

(2008) Megan J. Downie et al.   EUKARYOTIC CELL

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH