Journal
ISCIENCE
Volume 24, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2021.102995
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Aerobic fitness and physical activity play a crucial role in improving cardiometabolic risk markers and reducing mortality risk, more effectively than weight-loss programs. Weight loss does not necessarily reduce mortality risk, while intentional increases in physical activity can bring more benefits.
We propose a weight-neutral strategy for obesity treatment on the following grounds: (1) the mortality risk associated with obesity is largely attenuated or eliminated by moderate-to-high levels of cardiorespiratory fitness (CRF) or physical activity (PA), (2) most cardiometabolic risk markers associated with obesity can be improved with exercise training independent of weight loss and by a magnitude similar to that observed with weight-loss programs, (3) weight loss, even if intentional, is not consistently associated with lower mortality risk, (4) increases in CRF or PA are consistently associated with greater reductions in mortality risk than is intentional weight loss, and (5) weight cycling is associated with numerous adverse health outcomes including increased mortality. Adherence to PAmay improve if health care professionals consider PA and CRF as essential vital signs and consistently emphasize to their patients the myriad benefits of PA and CRF in the absence of weight loss.
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