4.6 Article

Hendra virus: Epidemiology dynamics in relation to climate change, diagnostic tests and control measures

Journal

ONE HEALTH
Volume 12, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.onehlt.2020.100207

Keywords

One health; Vaccine; Zoonosis; Climate change; Infectious disease; Biosecurity

Ask authors/readers for more resources

Hendra virus (HeV) remains a serious public health concern, with symptoms including frothy nasal discharge and ataxia. The Equivac (R) HeV vaccine is the most effective preventive measure, protecting horses and humans from infection.
Hendra virus (HeV) continues to pose a serious public health concern as spillover events occur sporadically. Terminally ill horses can exhibit a range of clinical signs including frothy nasal discharge, ataxia or forebrain signs. Early signs, if detected, can include depression, inappetence, colic or mild respiratory signs. All unvaccinated ill horses in areas where flying foxes exist, may potentially be infected with HeV, posing a significant risk to the veterinary community. Equivac (R) HeV vaccine has been fully registered in Australia since 2015 (and under an Australian Pesticides and Veterinary Medicines Authority special permit since 2012) for immunization of horses against HeV and is the most effective and direct solution to prevent disease transmission to horses and protect humans. No HeV vaccinated horse has tested positive for HeV infection. There is no registered vaccine to prevent, or therapeutics to treat, HeV infection in humans. Previous equine HeV outbreaks tended to cluster in winter overlapping with the foaling season (August to December), when veterinarians and horse owners have frequent close contact with horses and their bodily fluids, increasing the chance of zoonotic disease transmission. The most southerly case was detected in 2019 in the Upper Hunter region in New South Wales, which is Australia's Thoroughbred horse breeding capital. Future spillover events are predicted to move further south and inland in Queensland and New South Wales, aligning with the moving distribution of the main reservoir hosts. Here we (1) review HeV epidemiology and climate change predicted infection dynamics, (2) present a biosecurity protocol for veterinary clinics and hospitals to adopt, and (3) describe diagnostic tests currently available and those under development. Major knowledge and research gaps have been identified, including evaluation of vaccine efficacy in foals to assess current vaccination protocol recommendations.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Veterinary Sciences

Successful treatment of a chronic oroantral fistula infected with extensively drug resistant bacteria using long-term oesophageal tube feeding and several non-conventional treatments in a horse

J. R. Fletcher, K. Y. Yuen, A. J. Stewart, A. C. Young, J. S. Gibson, O. A. James, C. E. Medina-Torres, B. M. Forde, A. Sole-Guitart

Summary: Chronic oroantral fistulae (OAF) with secondary sinusitis can occur in horses following repulsion of cheek teeth. This case report describes the successful treatment of a complicated OAF with concurrent MDR Escherichia coli infection using various therapeutic strategies. Whole-genome sequencing may be beneficial in guiding antimicrobial selection for MDR or XDR infections in the future.

AUSTRALIAN VETERINARY JOURNAL (2022)

Article Veterinary Sciences

Fatal non-traumatic gas gangrene caused by Clostridium perfringens type A in a Siberian Husky dog

Cleide H. Sprohnle-Barrera, Justine S. Gibson, Rochelle Price, Rikki M. Graham, Amy Jennison, Madeline R. Ricca, Rachel E. Allavena

Summary: This study reports a case of severe subcutaneous emphysema and multi-organ failure in a Siberian Husky dog. Pathological and genetic analysis revealed Clostridium perfringens type A as the causative pathogen with multiple virulence-related genes.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION (2022)

Article Virology

Epidemiological Study of Multiple Zoonotic Mosquito-Borne Alphaviruses in Horses in Queensland, Australia (2018-2020)

Ka Y. Yuen, Joerg Henning, Melodie D. Eng, Althea S. W. Wang, Martin F. Lenz, Karen M. Caldwell, Mitchell P. Coyle, Helle Bielefeldt-Ohmann

Summary: The seroprevalence of common mosquito-borne virus infections in horses in Australia, as well as the impact of climate change on the epidemiology of these diseases, was investigated in this study. It was found that Ross River virus is the most common arbovirus infection in horses, followed by Barmah Forest virus. The potential use of horses as sentinels for arbovirus monitoring and the cross-reactivity of antibodies between different viruses should be further studied.

VIRUSES-BASEL (2022)

Article Veterinary Sciences

Hendra Virus An Update on Diagnosis, Vaccination, and Biosecurity Protocols for Horses

Xueli Wang, Jessica C. Wise, Allison J. Stewart

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE (2023)

Article Multidisciplinary Sciences

Social and cognitive factors influencing commercial chicken farmers' antimicrobial usage in Bangladesh

Tasneem Imam, Justine S. Gibson, Suman Das Gupta, Mohammad Foysal, Shetu B. Das, Md Ahasanul Hoque, Guillaume Fournie, Joerg Henning

Summary: Adapting the Social Cognitive Theory framework, a cross-sectional study was conducted on 137 commercial chicken farms in Bangladesh to investigate factors influencing farmers' behavior towards the application of antimicrobials. The study found that almost all farmers used antimicrobials for treating poultry diseases, with a significant percentage also using them for healthy growth and increased production. The inappropriate usage of antimicrobials was primarily driven by short-term goals, while farmers' perception of control over antimicrobial administration had a marginal influence. The study suggests the need for targeted education programs to reduce antimicrobial application in poultry flocks.

SCIENTIFIC REPORTS (2023)

Article Veterinary Sciences

Evaluation of an HMGA2 variant contribution to height and basal insulin concentrations in ponies

Brianna L. Clark, Nicholas J. Bamford, Allison J. Stewart, Molly E. McCue, Aaron Rendahl, Simon R. Bailey, Francois-Rene Bertin, Elaine M. Norton

Summary: The study revealed that the HMGA2:c.83G>A variant is associated with decreased height and higher insulin concentrations in ponies across different breeds. This variant explains 90.5% of the height variation and 7.1% of the insulin variation. Ponies with the A/A genotype are over 10 cm shorter than other genotypes, and A/A and G/A individuals have significantly higher basal insulin concentrations compared to G/G individuals.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2023)

Article Veterinary Sciences

Development and application of a new liver pathology recording system for use in cattle abattoirs

Helen Owen, Emily Jones, Carla Kowald, Sebastian Hand, Michael McGowan, Rowland Cobbold, Tamsin S. Barnes, Justine S. Gibson, Shahab Ranjbar, Chiara Palmieri, Rachel Allavena

Summary: This study aimed to create a post-mortem data collection tool for evaluating liver diseases in Australian beef cattle and to analyze the pathological findings in both normal and condemned livers. The study developed an efficient tool for rapid assessment of large numbers of cattle livers, allowing thorough investigation into the impact of liver disease on beef production.

RESEARCH IN VETERINARY SCIENCE (2023)

Article Multidisciplinary Sciences

Nasal microbiota profiles in shelter dogs with dermatological conditions carrying methicillin-resistant and methicillin-sensitive Staphylococcus species

Sara Horsman, Erika Meler, Deirdre Mikkelsen, John Mallyon, Hong Yao, Ricardo J. Soares Magalhaes, Justine S. S. Gibson

Summary: This study investigates the associations between Staphylococcus spp. infections and nasal microbiota in a canine animal shelter population. It reveals that shelter dogs with dermatological conditions have different nasal microbial communities compared to those without dermatological conditions, with decreased diversity and abundance. The study emphasizes the importance of exploring decolonization and probiotic therapies for restoring the nasal microbiota.

SCIENTIFIC REPORTS (2023)

Review Agriculture, Dairy & Animal Science

Animal and Human Dirofilariasis in India and Sri Lanka: A Systematic Review and Meta-Analysis

Sandani S. Thilakarathne, Nicholas K. Y. Yuen, Mohammad Mahmudul Hassan, Thishan C. Yahathugoda, Swaid Abdullah

Summary: This study evaluated the distribution and prevalence of dirofilariasis in Sri Lanka and India, finding that most cases in these countries are subcutaneous infections, with the eye being the most commonly affected organ. India has both heartworm and subcutaneous infections in dogs, while Sri Lanka has only reported subcutaneous infections. The distribution pattern and reasons behind this difference require further research.

ANIMALS (2023)

Article Veterinary Sciences

Right dorsal colitis in horses: A multicenter retrospective study of 35 cases

Jordan Flood, David Byrne, Jennifer Bauquier, Gustavo Ferlini Agne, Jessica C. Wise, Carlos E. Medina-Torres, Kelly Wood, Olivia Sullivan, Allison J. Stewart

Summary: Right dorsal colitis (RDC) is a gastrointestinal disease in horses caused by nonsteroidal anti-inflammatory drugs (NSAIDs), which can have serious consequences. Overdose of NSAIDs is a common cause, and clinical presentations include diarrhea, colic, and increased heart rate. According to the analysis of clinical data, increased heart rate, increased packed cell volume, and abnormal appearance of mucous membranes are associated with a significantly decreased survival rate.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2023)

Article Veterinary Sciences

Mapping of dressed and processed poultry products in Bangladesh: Identifying the food safety risks for policy intervention

Jinnat Ferdous, Md Helal Uddin, Rashed Mahmud, Mathew Hennessey, Abdullah Al Sattar, Suman Das Gupta, Justine S. Gibson, Robyn Alders, Joerg Henning, Guillaume Fournie, Md. Ahasanul Hoque

Summary: Bangladesh's commercial poultry production is rapidly growing, primarily due to the perception that processed poultry provides safer food than traditional live bird markets. However, this study found a lack of consistency in quality control and meat traceability within the dressed and processed poultry production and distribution network (PDN). This raises concerns about the safety of dressed poultry products and the potential increase in food-borne disease risks.

VETERINARY RESEARCH COMMUNICATIONS (2023)

Correction Veterinary Sciences

Mapping of dressed and processed poultry products in Bangladesh: Identifying the food safety risks for policy intervention (Jun, 10.1007/s11259-023-10153-7, 2023)

Jinnat Ferdous, Helal Uddin, Rashed Mahmud, Mathew Hennessey, Abdullah Al Sattar, Suman Das Gupta, Justine S. Gibson, Robyn Alders, Joerg Henning, Guillaume Fournie, Ahasanul Hoque

VETERINARY RESEARCH COMMUNICATIONS (2023)

Article Marine & Freshwater Biology

Identification of Antimicrobial Resistance in Faecal Microbes from Wild Dugongs (Dugong dugon)

Alexandra M. McGowan, Jennifer M. Seddon, Janet M. Lanyon, Nicholas Clark, Justine S. Gibson

Summary: Bacterial isolates cultured from the fresh faeces of dugongs in Queensland, Australia, showed resistance to antibiotics such as penicillin and trimethoprim, and contained various resistance and virulence genes. This highlights the role that dugongs can play as a sentinel species for antimicrobial resistance in coastal waters.

AQUATIC MAMMALS (2023)

Review Agriculture, Dairy & Animal Science

Insect Bite Hypersensitivity in Horses: Causes, Diagnosis, Scoring and New Therapies

Abbey Cox, Allison J. Stewart

Summary: Insect Bite Hypersensitivity (IBH) is the most common pruritic disease of horses, caused by sensitivity to the saliva of biting midges or other insects. It affects up to 60% of horses in some areas and has significant welfare concerns. There is currently no cure, but management strategies include minimizing insect bites and symptomatic therapy with corticosteroids and antihistamines. New therapies such as vaccines and desensitization procedures show promise in controlling hypersensitivity reactions.

ANIMALS (2023)

Article Veterinary Sciences

The Effect of Disease and Injury on Faecal Cortisol Metabolites, as an Indicator of Stress in Wild Hospitalised Koalas, Endangered Australian Marsupials

Flavia Santamaria, Rolf Schlagloth, Ludovica Valenza, Rupert Palme, Deidre de Villiers, Joerg Henning

Summary: Habitat loss, urbanisation and climate change can cause stress in koalas. Non-invasive monitoring of faecal cortisol metabolites (FCMs) can be used to evaluate the impact of stress. The effectiveness of two enzyme immunoassays (EIAs), 50c and cortisol, in measuring FCM values in wild, stressed koalas was tested. Diseased and injured koalas had significantly higher FCM values than clinically healthy control animals as measured by the 50c EIA. Only the 50c EIA detected higher absolute values in males, and also found that females showed a more elevated response to stress manifested by injury and disease. The cortisol EIA was also found unreliable in detecting stress in rehabilitated koalas treated with synthetic glucocorticoids as it cross-reacts with these chemicals.

VETERINARY SCIENCES (2023)

No Data Available