Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review

Stroke is a leading cause of death worldwide, and about a quarter of stroke patients are dead within 1 month. The prognosis is even worse for those with hemorrhagic stroke because the 1-month mortality approaches 50%. Besides, most patients who survive experience complications such as nausea, vomiting, and chronic pain. These adverse experiences, especially the existence of chronic pain, can lead to a decline in the patient's quality of life. In order to improve the treatment and prognosis of hemorrhagic stroke, there is an urgent need to understand its pathophysiological mechanism as well as the chronic pain it induces. This paper reviews studies of the molecular mechanisms of hemorrhagic stroke, especially the activation of microglia and the relationship between microglia and pain after stroke, which could shed new light on hemorrhagic stroke treatment.

Automated summary

Stroke is a leading cause of death worldwide, with about a quarter of stroke patients dead within 1 month, and the prognosis for those with hemorrhagic stroke is even worse, approaching 50% mortality within 1 month. Survivors often experience complications such as nausea, vomiting, and chronic pain, which can significantly impact their quality of life. Further research on the molecular mechanisms of hemorrhagic stroke, especially the role of microglia and pain after stroke, could provide new insights for treatment.