Article
Cardiac & Cardiovascular Systems
Yin Wang, Wenming Li, Tingrui Zhao, Yao Zou, Tao Deng, Zhangyou Yang, Zhiyi Yuan, Limei Ma, Ruihong Yu, Tingting Wang, Chao Yu
Summary: Th17 cells play important roles in regulating inflammation in hyperlipidemic patients and different stages of atherosclerosis, supporting the potential of IL-17 as a therapeutic target for the treatment of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Li-Wei Dong, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Deming Sun, Cheng Lan
Summary: This study found that modulation of adenosine 2A receptor (A2AR) can promote the Th17 polarization of CD4+ T cells and increase the incidence of post-infectious irritable bowel syndrome (PI-IBS). Additionally, the A2AR antagonist improved the clinical symptoms of PI-IBS, such as abdominal withdrawal reflex and colon transportation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Yangke Cai, Xuan Jia, Liyi Xu, Hanwen Chen, Siyuan Xie, Jianting Cai
Summary: This study used Mendelian Randomization analysis to confirm the causal associations between different subtypes of IL-17 and inflammatory bowel disease (IBD). IL-17B, IL-17E, and IL-17RB were found to be significantly associated with an increased risk of ulcerative colitis (UC), while IL-17C and IL-17RC showed causal effects on the increased risk of Crohn's disease (CD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Hongyun Liu, Xiaoyan Liu, Guoyang Zhang, Jieyu Wang, Duolan Naren, Shuangfeng Xie, Yiqing Li, Danian Nie, Zhixiong Li, Liping Ma
Summary: This study found that patients with ITP have higher concentrations of Th1 and Th17 cells and lower levels of Treg cells. Treatment outcomes showed that higher levels of Th2 and IL-2 were associated with treatment resistance, while the CR group had elevated levels of IL-17. Moreover, patients who required 2x pulses of high-dose DXM after 30 days of treatment had higher levels of Th2 cells, suggesting that lower Treg cells may predict a positive response.
THROMBOSIS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anna Tosi, Lavinia Nardinocchi, Maria Luigia Carbone, Lorena Capriotti, Elena Pagani, Simona Mastroeni, Cristina Fortes, Fernanda Scopelliti, Caterina Cattani, Francesca Passarelli, Antonio Rosato, Stefania D'Atri, Cristina Maria Failla, Andrea Cavani
Summary: The study found that in cutaneous melanoma, there is a lower percentage of Th17 lymphocytes compared to basal cell carcinomas, and TIL clones could not differentiate into the Th17 phenotype in vitro. The presence of Th17 cells did not correlate with patient characteristics, but a lower amount was observed in samples from female donors. The expression of placenta growth factor by melanoma cells may be associated with the presence of Th17 lymphocytes.
Review
Biochemistry & Molecular Biology
Raquel Gomez-Bris, Angela Saez, Beatriz Herrero-Fernandez, Cristina Rius, Hector Sanchez-Martinez, Jose M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD) refers to chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, presenting as Crohn's disease (CD) or ulcerative colitis (UC). It is characterized by exacerbated innate and adaptive immunity in the gut, along with microbiota dysbiosis and disruption of the intestinal barrier, leading to increased bacterial exposure. CD4 T-cells play a crucial role in the development of IBD, with various phenotypes and interactions with other immune cells determining the progression of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li-En Hsieh, Jaeyoon Song, Alba Grifoni, Chisato Shimizu, Adriana H. Tremoulet, Kirsten B. Dummer, Jane C. Burns, Alessandro Sette, Alessandra Franco
Summary: In this study, SARS-CoV-2-specific T cell responses were analyzed in 22 subacute MIS-C children. CD4+ and CD8+ T cell responses were detected in some subjects, and a subset of DN T cells recognizing SARS-CoV-2 peptides was observed. T cell epitope spreading and increased magnitude of Th and CTL responses were noted during the follow-up period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lisanne Lutter, Jose J. M. ter Linde, Eelco C. Brand, David P. Hoytema van Konijnenburg, Britt Roosenboom, Carmen Horjus Talabur-Horje, Bas Oldenburg, Femke van Wijk
Summary: This study investigates the role of the mucosal immune system in the development and progression of inflammatory bowel diseases. It finds that inflammation mainly affects the gut epithelium rather than the lamina propria, leading to changes in CD4 T-cell populations and compartment-specific programming. Overall, intraepithelial adaptation leads to a dampening of broad (pro-inflammatory) responses and tight regulation of lifespan, regardless of inflammation.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Minhao Yu, Hui Ding, Shuai Gong, Yang Luo, Haiping Lin, Yifei Mu, Hao Li, Xiaobo Li, Ming Zhong
Summary: This study found that intestinal fungi play a role in regulating immune responses in inflammatory bowel disease (IBD). Antibiotic-mediated depletion of fungi facilitated IBD development. Fungi enhance oxidative phosphorylation (OXPHOS) by enhancing glutaminolysis. Mechanistically, fungi activate the dectin-1-Syk-NF-kappa B signaling pathway to promote the expression of key enzymes and transporters involved in glutaminolysis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Yi Liu, Xiao-Qi Chen, Fang Wang, Bo Cheng, Gang Zhou
Summary: This study found that serum and saliva melatonin levels were lower in pSS patients than in healthy controls, which were negatively correlated with disease activity. Melatonin alleviated the inflammatory responses of Th17 and DN T cells in PBMCs from pSS patients in a nuclear receptors-dependent manner, suggesting potential benefits of melatonin for pSS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson, Marcel Wuthrich, Bruce Klein
Summary: Using single cell transcriptome analysis, we identified transcriptionally diverse and distinctive antigen-specific T cells associated with protective vaccine-induced immunity. These cells exhibited a strong type I interferon response and high expression of the natural killer cell marker gene NKG7. We also observed differences in TCR gene use and Th1 and Th17 skewed responses after protective and nonprotective vaccination.
Article
Cell Biology
Lina Wu, Lu Wang, Xin Chai
Summary: This study aims to understand the role of granulocyte-macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in the pathophysiology of mouse experimental autoimmune uveitis (EAU). The study found that ThGM cells were present in the spleen and the eye after EAU induction, and they had an impact on the severity of EAU.
CELLULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Review
Immunology
Xinzou Fan, Panyin Shu, Ying Wang, Ning Ji, Dunfang Zhang
Summary: Neutrophils are the predominant immune cells in human peripheral circulation that play a crucial role in fighting infections, autoimmune diseases, and cancer. This review discusses the physiological roles of Th17 cells and neutrophils, their interactions, and their involvement in pathological processes. The study also provides a summary of drugs targeting IL-17A and their clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Michael J. Rosen
Article
Gastroenterology & Hepatology
Ryan W. Stidham, Deahan Yu, Xinyan Zhao, Shrinivas Bishu, Michael Rice, Charlie Bourque, Vinod V. G. Vydiswaran
Summary: This study developed a natural language processing (NLP) system to identify the presence and status of extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients using clinical notes. The results showed that NLP methods can accurately detect and infer the activity status of EIMs, offering exciting possibilities for population-based research and decision support in IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Michael J. Duryee, Rizwan Ahmad, Derrick D. Eichele, Carlos D. Hunter, Ananya Mitra, Geoffrey A. Talmon, Shailender Singh, Lynette M. Smith, Michael J. Rosen, Punita Dhawan, Geoffrey M. Thiele, Amar B. Singh
Summary: This study found that circulating IgG anti-MAA antibody levels can serve as a novel, noninvasive, and highly sensitive test to identify patients with UC and possibly differentiate them from patients with CD.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Review
Allergy
Dilawar Khokhar, Sahiti Marella, Gila Idelman, Joy W. Chang, Mirna Chehade, Simon P. Hogan
Summary: Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by upper gastrointestinal symptoms. The underlying allergic inflammatory response and dysregulation of key epithelial barrier genes are thought to contribute to the disease manifestations. Further research is needed to fully understand the clinical and histological aspects of EoE.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Allergy
Varsha Ganesan, Ankit Sharma, Sunil Tomar, Charles F. Schuler, Simon P. Hogan
Summary: Food allergy diagnosis and management pose challenges for individuals and their caregivers, leading to interest in predicting allergy severity and treatment outcomes. A murine model was used to study the effects of IL-4R alpha polymorphisms on clinical symptoms and treatment outcomes of food allergic reactions. The results show that IL-4R alpha polymorphisms can alter clinical symptoms, severity, and reactive dose of food allergic reactions in mice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kathryn Clarkston, Rebekah Karns, Anil G. Jegga, Mihika Sharma, Sejal Fox, Babajide A. Ojo, Phillip Minar, Thomas D. Walters, Anne M. Griffiths, David R. Mack, Brendan Boyle, Neal S. LeLeiko, James Markowitz, Joel R. Rosh, Ashish S. Patel, Sapana Shah, Robert N. Baldassano, Marian Pfefferkorn, Cary Sauer, Subra Kugathasan, Yael Haberman, Jeffrey S. Hyams, Lee A. Denson, Michael J. Rosen
Summary: This study aimed to predict clinical outcomes in pediatric ulcerative colitis (UC) through assessing gene expression and investigate the potential pathogenic roles of predictive genes. IL13RA2 was associated with corticosteroid-free remission, while RORC was associated with a lower likelihood of colectomy. RNA sequencing and immunostaining supported these findings.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Kaitlin G. Whaley, Ye Xiong, Rebekah Karns, Jeffrey S. Hyams, Subra Kugathasan, Brendan M. Boyle, Thomas D. Walters, Judith Kelsen, Neal LeLeiko, Jason Shapiro, Amanda Waddell, Sejal Fox, Ramona Bezold, Stephanie Bruns, Robin Widing, Yael Haberman, Margaret H. Collins, Tomoyuki Mizuno, Phillip Minar, Geert R. D'Haens, Lee A. Denson, Alexander A. Vinks, Michael J. Rosen
Summary: This study aimed to model the pharmacokinetics of infliximab (IFX) in pediatric acute severe ulcerative colitis (ASUC) and assess the association between IFX exposure and clinical response. The results showed that IFX exposure was not predictive of clinical outcomes in pediatric ASUC, and a higher initial dose may optimize early outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Dante Picchioni, Kathleen C. Schmidt, Inna Loutaev, Adriana J. Pavletic, Carrie Sheeler, Shrinivas Bishu, Thomas J. Balkin, Carolyn B. Smith
Summary: During sleep, protein synthesis is active in N1 and N2 stages, while similar to sleep-deprived awake state in N3 stage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Ciro M. Amato, Ariel Fricke, Sahiti Marella, Joshua P. Mogus, Michael Bereman, Krista A. McCoy
Summary: This study found that enhancing natural protective mechanisms can reduce the severity of pollutant-induced birth defects, such as hypospadias, through the use of Nrf2 activator, sulforaphane. The results showed that sulforaphane supplementation increased masculinization and reduced the occurrence and severity of hypospadias. The presence of Nrf2 was critical for the rescue effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michael A. Schumacher, Cambrian Y. Liu, Kay Katada, Megan H. Thai, Jonathan J. Hsieh, Britany J. Hansten, Amanda Waddell, Michael J. Rosen, Mark R. Frey
Summary: This study found that Sprouty2 limits the differentiation of colonic deep crypt secretory (DCS) cells by suppressing the IL13 signaling pathway. The DCS cells express high levels of the antimicrobial peptide RELM beta in homeostasis. Loss of Sprouty2 leads to the release of IL13, promoting the proliferation of DCS cells and increased levels of colonic RELM beta.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Allergy
Ankit Sharma, Matija Rijavec, Sunil Tomar, Amnah Yamani, Varsha Ganesan, James Krempski, Charles F. Schuler, Supinda Bunyavanich, Peter Korosec, Simon P. Hogan
Summary: This study aimed to identify dysregulated immunological processes associated with severe food allergic reactions by integrating bulk RNA-sequencing data from human and mouse samples. The results showed that genes related to innate and inflammatory immune responses, MAPK and NFkB signaling, as well as 429 genes correlated with reaction severity in mice. By comparing the mouse transcriptome with two independent human cohorts, 11 significantly dysregulated genes correlated with severity were identified. Additionally, during IgE-mediated reactions, rapid changes in blood leukocytes, particularly inflammatory monocytes and neutrophils, were observed along with changes in surface expression of CLEC4E, CD218A, and GPR27.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Gastroenterology & Hepatology
Elliot M. Berinstein, Jessica L. Sheehan, Janson Jacob, Calen A. Steiner, Ryan W. Stidham, Carol Shannon, Shrinivas Bishu, Jacob Levine, Shirley A. Cohen-Mekelburg, Akbar K. Waljee, Peter D. R. Higgins, Jeffrey A. Berinstein
Summary: Dual targeted therapy is a promising approach for improving the treatment of inflammatory bowel disease in patients who do not respond well to targeted monotherapy. However, more research is needed to confirm its effectiveness and identify the patients who would benefit the most from this treatment.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, Research & Experimental
Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman
Summary: This study analyzes patient data to identify dysregulation of long noncoding RNAs (lncRNAs) in inflammatory bowel diseases. The HNF1A-AS1 lncRNA is found to be reduced in ulcerative colitis and associated with disease severity. These findings provide potential targets for future preclinical studies.
Article
Gastroenterology & Hepatology
Eileen Crowley, Christopher Ma, Leonard Guizzetti, Guangyong Zou, Peter J. Lewindon, Michael S. Gee, Jeffrey S. Hyams, Michael J. Rosen, Daniel von Allmen, Anthony de Buck van Overstraeten, Lisa M. Shackelton, Julie Remillard, Lauren Schleicher, Jonathan R. Dillman, Jordi Rimola, Stuart A. Taylor, Joel G. Fletcher, Peter C. Church, Brian G. Feagan, Anne M. Griffiths, Vipul Jairath, Mary-Louise C. Greer
Summary: This study aims to determine the appropriateness of MRI-based disease activity indices, assessment methods, and clinical trial design for pediatric perianal fistulizing CD. The findings suggest that existing indices can be adapted and used for children, and further research is needed to assess their operating properties in a pediatric patient population.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jake Levine, Jey McKibbin, Rebecca Ham, Peter Higgins, Shrinivas Bishu, Jeffrey Berinstein
Article
Gastroenterology & Hepatology
Kyle G. Williams, Ramya Kongala, Donna M. Shows, Andrew J. Konecny, Duncan C. Hindmarch, Astrid S. Clarke, James D. Lord
Summary: CD8 T-cell clones are found homogeneously throughout the length of the colon in patients with inflammatory bowel disease (IBD), regardless of inflammation. There is a high degree of repertoire overlap for T-cell receptor (TCR) between the colon and peripheral blood, suggesting T-cell trafficking plays a significant role in the pathogenesis of IBD, particularly in relation to the alpha 4 beta 7+ T-cell subpopulation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Yueqi Zhang, Yue Luo, Xinhui Liu, Matti Kiupel, Aimin Li, Hongbing Wang, Qing-Sheng Mi, Hua Xiao
Summary: This study reveals a novel mechanism for the onset of NAFLD/NASH and HCC initiated by NCOA5-deficient macrophages, suggesting the NCOA5-PF4 axis in macrophages as a potential target for developing preventive and therapeutic interventions against NAFLD/NASH and HCC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Daria Krzikalla, Alena Laschtowitz, Lisa Leypoldt, Cornelia Gottwick, Pia Averhoff, Soren Weidemann, Ansgar W. Lohse, Samuel Huber, Christoph Schramm, Dorothee Schwinge, Johannes Herkel, Antonella Carambia
Summary: This study investigated the immune mechanisms that establish liver tolerance. It was found that MBP-specific T cells were activated to produce IFN-gamma in the liver, which induced the up-regulation of recruitment molecules and redirected the T cells into the liver parenchyma. Some of the translocated T cells converted into regulatory T cells producing IL-10 and up-regulated the expression of immune checkpoint molecules. The up-regulation of IFN gamma and immune checkpoint molecules, including CTLA-4, were essential for tolerance induction in the liver.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Review
Gastroenterology & Hepatology
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Summary: Liver fibrosis is a serious global health problem with no effective therapy currently available. Studies have shown that liver fibrosis is reversible and regression can occur when the underlying cause is removed. This review discusses the research progress in understanding the molecular mechanisms underlying the development and reversibility of liver fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Quan Pan, Mingming Gao, Dami Kim, Weiqi Ai, Wanbao Yang, Wen Jiang, Wesley Brashear, Yujiao Dai, Sha Li, Yuxiang Sun, Yajuan Qi, Shaodong Guo
Summary: This study investigates the role of hepatocyte FoxO1 in liver fibrosis and finds that it mediates CCL4-induced liver fibrosis through upregulating hepatocyte TGF-beta 1 expression, stimulating hepatic inflammation, and TGF-beta 1-mediated HSC activation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)