Article
Multidisciplinary Sciences
Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R. Jeffrey Karnes, Rafael Jimenez, Liguo Wang, Liewei Wang, Martin E. Gleave, Yuzhuo Wang, Lei Shi, Haojie Huang
Summary: Resistance to next-generation anti-androgen enzalutamide in castration-resistant prostate cancer (CRPC) is a major challenge. Through genome-wide ChIP-seq profiling, it was found that AR-dependent transcription of noncanonical targets drives an ENZ-resistant mechanism, making resistant cells susceptible to dual inhibition of BET and CBP/p300 signaling.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Jacob J. Orme, Lance C. Pagliaro, J. Fernando Quevedo, Sean S. Park, Brian A. Costello
Summary: This report provides a comprehensive overview of the evidence and rational sequencing strategies for the use of second-generation antiandrogens in prostate cancer treatment. It highlights the growing list of approvals and indications for these drugs and suggests a prioritization sequence for their use in different stages of the disease. The report concludes that an optimized sequencing of second-generation antiandrogens with other treatment options is feasible based on current data.
Article
Oncology
Dae-Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S. Rodansky, Joshua A. Urrutia, Jacob A. Schwartzman, Chao Zhang, Himisha Beltran, Mark P. Labrecque, Colm Morrissey, Jared M. Lucas, Ilsa M. Coleman, Peter S. Nelson, Eva Corey, Samuel K. Handelman, Jonathan Z. Sexton, Rahul Aggarwal, Wassim Abida, Felix Y. Feng, Eric J. Small, Daniel E. Spratt, Armand Bankhead, Arvind Rao, Emily M. Gesner, Sarah Attwell, Sanjay Lakhotia, Eric Campeau, Joel A. Yates, Zheng Xia, Joshi J. Alumkal
Summary: NEPC is the most aggressive lineage plasticity in prostate cancer, with limited treatment options. By inhibiting AR and using BET inhibitors, it is possible to block this lineage plasticity, showing promising potential for t-NEPC treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M. Mason, Lauren E. Jamieson, Grace H. McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H. Y. Kung, Marine Leclercq, Catriona A. Ford, Linda K. Rushworth, David J. McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J. Salji, Elke Markert, Gillian M. MacKay, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E. Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J. Murphy, Sara Zanivan, Hing Y. Leung
Summary: THEM6 has been identified as a marker of ADT resistance in PCa, with its deletion reducing tumor growth and restoring castration sensitivity. It regulates intracellular levels of ether lipids to induce the ER stress response, altering ER function and preventing lipid-mediated activation. High THEM6 expression is associated with poor survival and high levels of UPR activation in PCa patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jianzhong Ai, Jia Li, Qin Su, Hong Ma, Qiang Wei, Hong Li, Guangping Gao
Summary: This study found that PTEN and CDKN1B expression levels were significantly downregulated in prostate cancer cells, suggesting that modulating their expression could be a promising therapeutic approach. Overexpressing PTEN inhibited cell migration, cell-cycle progression, and promoted apoptosis in prostate cancer cells. Treatment with recombinant adeno-associated virus carrying PTEN or CDKN1B also inhibited tumor growth in mice models.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Huan Xu, Sangsang Li, Yi Sun, Lingfan Xu, Xin Hong, Zhong Wang, Hailiang Hu
Summary: This study reveals the impact of long-chain polyunsaturated fatty acid ELOVL5 on enzalutamide resistance and neuroendocrine differentiation in prostate cancer, providing a potential therapeutic target for treating enzalutamide-resistant NE-like prostate cancer.
Review
Oncology
Natalia Scaglia, Yesica Romina Frontini-Lopez, Giorgia Zadra
Summary: Advanced prostate cancer is the fifth leading cause of cancer death globally. Lipids and their metabolism have been increasingly recognized as playing a role in PCa development, progression, and metastasis. Targeting enzymes and transporters involved in lipid metabolism is a growing focus in therapeutic approaches for PCa. Studies also support dietary modulation in improving the efficacy of standard care and synthetic lethality in PCa treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shijia Pan, Yuan Guo, Fan Hong, Pengfei Xu, Yonggong Zhai
Summary: Colorectal cancer (CRC) is a common gastrointestinal malignancy with complex development processes. Obesity and dysbacteriosis are main risk factors, while melatonin plays a potential role in lipid metabolism and beneficial effects on CRC, and gut microbiota plays a significant role in the relationship between obesity and increased CRC risk.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Endocrinology & Metabolism
Reuben S. E. Young, Britt S. R. Claes, Andrew P. Bowman, Elizabeth D. Williams, Benjamin Shepherd, Aurel Perren, Berwyck L. J. Poad, Shane R. Ellis, Ron M. A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Summary: Prostate cancer diagnosis relies on biopsy and histopathology, which can vary between pathologists, leading to investigation of biomolecular markers. This study used isomer-resolved lipidomics and imaging mass spectrometry to explore lipid metabolic signatures in prostate cancer tissue sections, finding correlations between lipid isomers and pre-malignant lesions and inflammation. The results suggest a potential role for isomer-resolved mass spectrometry imaging in assisting pathologists with prostate cancer diagnoses and patient stratification.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
S. E. H. Detert Oude Weme, L. M. G. Hulskotte, W. L. Vervenne, A. L. T. Imholz, R. G. H. M. Cremers, K. Taxis, A. K. L. Reyners, I. R. F. van Berlo-van de Laar, F. G. A. Jansman, G. E. Benoist
Summary: This study evaluated the potential drug-drug interaction between enzalutamide and oxycodone. The results showed that enzalutamide significantly reduced the exposure to oxycodone and its active metabolite oxymorphone. Therefore, this interaction should be considered when prescribing enzalutamide combined with oxycodone.
CLINICAL PHARMACOKINETICS
(2023)
Review
Pharmacology & Pharmacy
Yuanyuan Wang, Jiyuan Chen, Zhengjie Wu, Weihong Ding, Shen Gao, Yuan Gao, Chuanliang Xu
Summary: This review examines the emerging information on resistance mechanisms to enzalutamide in castration-resistant prostate cancer, including various signaling pathways and metabolic effects, and suggests potential therapeutic strategies for overcoming enzalutamide resistance.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Zachary A. Schaaf, Shu Ning, Amy R. Leslie, Masuda Sharifi, Xianrui Han, Cameron Armstrong, Wei Lou, Alan P. Lombard, Chengfei Liu, Allen C. Gao
Summary: Treatment resistance is a common challenge in castration-resistant prostate cancer. This study examines the resistance patterns of different therapeutic classes and emphasizes the importance of rational drug sequencing in treatment. The findings reveal distinct cross-resistance characteristics among different resistant cell sublines and provide insights into the underlying mechanisms of resistance.
Article
Multidisciplinary Sciences
Anouk C. de Jong, Alexandra Danyi, Job van Riet, Ronald de Wit, Martin Sjostrom, Felix Feng, Jeroen de Ridder, Martijn P. Lolkema
Summary: In order to improve the response to androgen receptor signaling inhibitors (ARSI) in metastatic castration resistant prostate cancer (mCRPC), the discovery of biomarkers and development of machine learning-based prediction models are necessary. Researchers utilized whole-genomics and whole-transcriptomics to identify genomic markers and transcriptomic profiles associated with poor responders. Predictive models combining genomic, transcriptomic, and clinical data can potentially enhance treatment guidance for mCRPC patients.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Marvin C. J. Lim, Anne-Marie Baird, John Greene, Ciara McNevin, Karine Ronan, Petar Podlesniy, Orla Sheils, Steven G. Gray, Ray S. McDermott, Stephen P. Finn
Summary: This study evaluated the role of circRNAs in enzalutamide-resistant prostate cancer, identifying hsa_circ_0001275 as a potential therapeutic target. The research also explored the trend of circRNA expression in patient plasma, showing a possible association with enzalutamide resistance.
Article
Biochemistry & Molecular Biology
Eunjeong Seo, Byula Jee, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Minyong Kang
Summary: In this study, the researchers discovered that the AR-V7/YAP1/TAZ axis represses the expression of SLC22A3, leading to resistance to enzalutamide (ENZ) in metastatic castration-resistant prostate cancer (mCRPC). This finding provides new insights into potential treatment targets for prostate cancer.
Article
Engineering, Chemical
Chao Yang, Zhelin Su, Yeshuang Wang, Huiling Fan, Meisheng Liang, Zhaohui Chen
Summary: A series of ZnO/SiO2 adsorbents was prepared using a sol-gel method, and the impact of gel drying temperature on their structure and desulfurization performance was investigated. It was found that low drying temperature resulted in weak interactions in the gel system, leading to oxidation of ethylene glycol (EG) and the formation of zinc glyoxylate complex. The formation of this complex hindered the desulfurization performance of the adsorbents. On the other hand, drying the gel at 120 degrees C improved the interactions in the gel system and resulted in the formation of ZnO nanoparticles with a size of 6 nm, leading to a higher sulfur capacity of 104.9 mg center dot g (-1).
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Shuli Sun, Zhen Ma, Zhaohui Chen, Pu Liu, Yu Song, Qiang Lu, Xiaoxiao Fu, Qiang Wang, Weibin Cui
Summary: Seven novel inherently nanolaminated transition metal carbides with R in-plane chemical ordering in the carbide sheet have been synthesized and crystallized in Cmcm orthorhombic structure. The Vickers hardness of these compounds is significantly higher than that of Cr2AlC benchmark, resulting in higher compressive fracture strength and better wear resistance. The compression at high temperature reveals the nanoscale co-existence of monoclinic and orthorhombic structures, which is caused by random stackings and high-density slidings within ab plane.
Article
Chemistry, Inorganic & Nuclear
Juanjuan Zheng, Maierhaba Abudoureheman, Peng Wang, Alimujiang Yalikun, Bo Wei, Zhaohui Chen, Lin Sun, Jun Zhang
Summary: A mixed-alkaline metal copper-containing phosphate LiKCuP2O7 has been synthesized by cation substitution, and its structure has been studied in detail. The compound exhibits a unique 3D network structure, where CuO5 polyhedra are interconnected with P2O7 units via vertex-sharing O atoms to form 2D layers. Additionally, the compound shows antiferromagnetic behavior.
INORGANICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Mingbin He, Lijing Zou, Zhaohui Chen, Ruoming Huang
Summary: Anti-reversion agents play a crucial role in sulfur-cured natural rubber. In this study, five structurally different bis-citraconimides were synthesized and their effects on the cure characteristics, cross-linked structure, and physical-mechanical properties of sulfur-cured natural rubber were investigated. The results provide valuable information on the differences in reactivity and cross-linking chemistry of the anti-reversion agents.
JOURNAL OF ELASTOMERS AND PLASTICS
(2023)
Article
Chemistry, Multidisciplinary
Yuemei Liu, Junhong Ma, Tuan K. A. Hoang, Lijing Yang, Zhaohui Chen
Summary: NiFe-based nanoparticles attached to heteroatom-doped carbon demonstrate efficient catalytic activity for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). This study presents a two-stage pyrolysis approach to prepare nitrogen-doped carbon encapsulated Ni3Fe nanoparticles (Ni3Fe@NC), which shows uniform distribution and enhanced synergism with NC layers. The Ni3Fe@NC-600 exhibits improved catalytic performance and durability, making it a promising bifunctional oxygen electrocatalyst.
Article
Chemistry, Multidisciplinary
Hongyu Huang, Na Li, Ruixin Zhang, Xinmei Wang, Xianmeng He, Lei Wu, Lili Liu, Qun Jing, Zhaohui Chen
Summary: In this work, four new Sb-based phosphates were successfully synthesized, and two new Rb-containing alkali metal Sb-based phosphates were discovered. A detailed structural comparison showed that the structure dimensions of these compounds transitioned from 1D to complex 3D frameworks with the increase of (Sb+P)/O ratio, which affected their performances. Optical property and energy band structure calculations based on DFT were also performed, laying the foundation for further exploration of their optical properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xianmen He, Lu Qi, Wenyao Zhang, Ruixin Zhang, Xiaoyu Dong, Junhong Ma, Maierhaba Abudoureheman, Qun Jing, Zhaohui Chen
Summary: Regulating the crystal structure through A-site cation substitution is an effective method for exploring high-performance nonlinear optical materials. In this study, two non-centrosymmetric compounds, alpha-LiZnPO4 and alpha-KZnPO4, were obtained by A-site cation substitution, with short UV absorption edges at 221 and 225 nm, respectively. It is noteworthy that alpha-LZPO achieved more than 10 times second harmonic generation (SHG) enhancement compared to alpha-KZPO, which is the only case among phosphates with different A-site cations. Structural analysis and theoretical calculations were conducted to understand the role of A-site cations in anion rearrangements and the structural features of the two compounds. This study confirms the feasibility of designing promising NLO materials with enhanced SHG response and structural stability in the orthophosphate system.
Article
Multidisciplinary Sciences
Shuyu Wang, Xiaohui Ma, Shenghui Zhou, Lixin Wu, Hong Wang, Zhili Tang, Guangzhi Xu, Zhao Jing, Zhaohui Chen, Bolan Gan
Summary: Extreme atmospheric rivers (EARs) are responsible for severe precipitation and flooding along coastal regions. Current climate models underestimate EARs, but a new high-resolution simulation shows significant improvement in their prediction and projects a doubling or more of EARs occurrence with global warming.
NATURE COMMUNICATIONS
(2023)
Article
Crystallography
Tao Zhang, Haoran Wang, Chongmei Peng, Zhaohui Chen
Summary: This paper introduces a linear-to-dual-circular polarization metasurface decomposer, which can transform a linearly polarized wave into two circular polarized waves. The proposed design consists of rotated trimming stub loaded circular patches to achieve the desired phase gradients. A 12 x 12 metasurface polarization decomposer is designed, fabricated, and measured, showing good agreement between simulated and measured results.
Article
Agriculture, Dairy & Animal Science
Tianxu Liu, Chenxi Gao, Shenfei Long, Qianqian Wang, Tengfei He, Zhenlong Wu, Zhaohui Chen
Summary: This study aimed to investigate the effects of drinking heated water on the growth performance, serum biochemical indexes, nutrient digestibility, and ruminal fermentation function of yak calves. The results showed that drinking heated water significantly increased weight gain, immune function, nutrient digestibility, and ruminal fermentation function compared with drinking cold water. Overall, drinking heated water at 20°C improved the performance of yak calves in terms of better nutrient digestibility and ruminal function.
Article
Thermodynamics
Mohammad Monzavi, Zhaohui Chen, Abdelrahman Hussain, Jamal Chaouki
Summary: This study proposed a method of upgrading heavy oils and plastic waste to high quality products using microwave catalytic pyrolysis. By employing a unique design of the catalyst, sufficient mass and heat transfer and enhanced catalyst surface area were achieved. The addition of LDPE eliminated hazardous elements of heavy oil and promoted secondary and side reactions, resulting in optimized product yield and quality.
APPLIED THERMAL ENGINEERING
(2023)
Article
Materials Science, Ceramics
Zhuang Lin, Ben Ma, Zhaohui Chen, Yingke Zhou
Summary: Commercial use of solid oxide fuel cells (SOFCs) requires high output performance and excellent long-term stability. In this study, a nanostructured spinel high-entropy oxide (Fe0.2Mn0.2Co0.2Ni0.2Zn0.2)3O4 (FMCNZ) was developed as the SOFC cathode using an impregnation method. The FMCNZ cathode showed higher oxygen reduction reaction (ORR) performance compared to traditional spinel cathodes, attributed to the diversity of surface metal cations and the increase of surface oxygen vacancies brought on by the high entropy design. The nanostructured FMCNZ cathode exhibited stable performance after 100 hours of cell operation, providing a promising path for developing high-performance cathodes.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Ruixin Zhang, Xiuhua Cui, Haiming Duan, Qun Jing, Zhaohui Chen, Ming-Hsien Lee, Haibin Cao
Summary: In this paper, the electronic structures, optical properties, and polarization of AlPS4 compounds were investigated. The results showed that all compounds had relatively large birefringence, which was related to the induced polarization under external electronic field. The tetragonal structures of AlS4 and PS4 contributed significantly to the birefringence and second harmonic generation response.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Engineering, Environmental
Zhaohui Chen, Jiacong Wu, Wenrui Huang, Yuanyuan Li, Yanli Mao, Juan Han, Yun Wang, Liang Ni
Summary: In this study, UCST-type temperature-responsive polymer was combined with horseradish peroxidase (HRP) to produce a smart polymerase with enhanced stability. The smart polymerase exhibited strong temperature stability, pH stability, and storage stability compared to free enzymes. It was capable of degrading 91% of phenol in a 100 mg/L phenol solution within 1 hour and removing a significant amount of phenol from real water samples.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Energy & Fuels
Jiehan Zhang, Mingyu Ma, Zhaohui Chen, Xinyu Zhang, Hang Yang, Xinkun Wang, Hongbo Feng, Jian Yu, Shiqiu Gao
Summary: Ex-situ catalytic pyrolysis of low-density polyethylene (LDPE) was performed using a two-stage fixed bed. Results showed that Ga/ZSM-5 and Ga/P/ZSM-5 catalysts were beneficial for the production of olefins and aromatics, and the introduction of P improved the selectivity of aromatics. Compared to in-situ catalytic pyrolysis, ex-situ catalytic pyrolysis was identified as a better method for processing plastic waste.
JOURNAL OF THE ENERGY INSTITUTE
(2023)