Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Pathology
Chen Wang, Tao Ding, Deping Yang, Ping Zhang, Xiongmin Hu, Wei Qin, Jianghua Zheng
Summary: OGFRP1 functions by sequestering miR-149-5p to indirectly promote upregulation of IL-6, thus increasing chemoresistance in PC cells. This OGFRP1/miR-149-5p/IL-6 axis may serve as a promising target for sensitizing and treating PC chemoresistance.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xu Zhao, Jizhao Wang, Rui Zhu, Jing Zhang, Yunfeng Zhang
Summary: DLX6-AS1 regulates cisplatin sensitivity of lung squamous cell carcinoma cells through the miR-181a-5p/miR-382-5p/CELF1 axis, playing a key role in promoting secondary cisplatin resistance. Targeting DLX6-AS1 may be a novel approach to overcome cisplatin resistance in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Long Huang, Gang Dai
Summary: This study reveals the overexpression of lncRNA DCST1-AS1 in colorectal cancer (CRC) tissues and cell lines, which is associated with poor prognosis in CRC patients. Functional experiments confirm the role of lncRNA DCST1-AS1 in promoting malignant phenotypes of CRC cells. Furthermore, the study identifies the binding sites between lncRNA DCST1-AS1 and hsa-miR-582-5p, as well as between hsa-miR-582-5p and High Mobility Group Box 1 (HMGB1), which play a crucial role in modulating the aggressiveness of CRC cells.
Article
Immunology
Shengqiang Fu, Qiaoyun Fan, Juntao Xu, Shengjun Yu, Ming Sun, Yuan Ji, Dun Liu
Summary: Circular RNA circ_0008956 is highly expressed in OA and acts as a sponge for miR-149-5p to up-regulate NAMPT expression, contributing to IL-1 beta-induced growth arrest and ECM degradation. This study provides new insights into the pathogenesis of OA and identifies a potential therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Qing Li, Dachuan Zhang, Hui Wang, Jun Xie, Lei Peng, Yan Peng, Xiao Zheng, Jingting Jiang
Summary: The overexpression of SLCO4A1-AS1 in gastric cancer promotes cell proliferation, migration, and invasion, inhibits apoptosis, and may mediate these effects through miR-149-5p and STAT3. miR-149-5p mimic can suppress the malignant development of gastric cancer cells.
JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Linlin Qu, Yan Chen, Fan Zhang, Liang He
Summary: The study found that DLGAP1-AS1 plays a crucial role in the progression of colorectal carcinoma and 5-FU resistance through the miR-149-5p/TGFB2 regulatory axis. Silencing DLGAP1-AS1 inhibited cell proliferation and invasiveness, while enhancing the sensitivity of CRC cells to 5-FU chemotherapy.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Cell Biology
Yanling Tao, Jingjing Zhang, Lulu Chen, Xin Liu, Mingkang Yao, Hao Zhang
Summary: High expression of CD27-AS1 in AML is associated with shorter overall survival time, its downregulation can inhibit the proliferation and induce apoptosis of AML cells, while overexpression enhances the malignant phenotype. CD27-AS1 regulates the growth of AML cells through the miR-224-5p/PBX3/MAPK signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Fei Xu, Qun-Fang Hu, Jia Li, Chang-Jiang Shi, Jin-Wei Luo, Wei-Chao Tian, Li-Wei Pan
Summary: In this study, the expression and underlying network of long non-coding RNA (lncRNA) MCM3AP-AS1 in osteoarthritis (OA) were investigated. The results showed that MCM3AP-AS1 was upregulated in OA patients and IL-1 beta-induced chondrocytes. Knockdown of MCM3APAS1 enhanced autophagy, while alleviating extracellular matrix (ECM) degradation and cartilage injury. Mechanistically, MCM3AP-AS1 acted as a molecular sponge or epigenetic regulator of miR-149-5p to facilitate Notch1 expression. Inhibition of MCM3AP-AS1 might be a potential treatment strategy of OA.
Article
Immunology
Yeuni Yu, Sohee Park, Hansong Lee, Eun Jung Kwon, Hae Ryoun Park, Yun Hak Kim, Seung-Geun Lee
Summary: This study aimed to develop potential biomarkers for rheumatoid arthritis (RA) by sequencing small non-coding RNA (sncRNA) in circulating exosomes. The expression levels of hsa-miR-335-5p and hsa-miR-486-5p were found to be higher in RA patients compared to healthy controls, while the expression of the SRSF4 gene was decreased. These findings suggest that circulating exosomal miRNAs and SRSF4 could serve as valuable biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pediatrics
Jing Zhao, Daye Chen
Summary: SOCS2-AS1 promotes the progression of HUVECs in KD by upregulating CUEDC2 through inhibiting miR-324-5p. These findings provide new insights for KD treatment.
PEDIATRIC RESEARCH
(2022)
Article
Oncology
Xu Zhao, Yajun Liu, Chenggong Luo, Yali Zuo
Summary: AGAP2-AS1, acting as an oncogene in some cancers like prostate cancer, is highly expressed in PCa cells and promotes cell growth by sponging miR-628-5p and regulating the expression of FOXP2. The feedback loop among AGAP2-AS1, miR-628-5p, and FOXP2 facilitates PCa cell growth by activating the WNT pathway.
Article
Medicine, Research & Experimental
Jose L. Sanchez-Gloria, Roxana Carbo, Mabel Buelna-Chontal, Horacio Osorio-Alonso, Adrian Henandez-Diazcouder, Rosa Luz de la Fuente-leon, Julio Sandoval, Fausto Sanchez, I. Rubio-Gayosso, Fausto Sanchez-Munoz
Summary: Chronic cold exposure exacerbates MCT-induced pulmonary arterial hypertension in rats, resulting in increased levels of inflammatory markers and miRNAs in plasma EVs and lungs.
Article
Oncology
Aliza Mohd Yacob, Nor Asiah Muhamad, Kian Meng Chang, Hamidah Akmal Hisham, Yuslina Mat Yusoff, Latifah Ibrahim
Summary: The study used Next Generation Sequencing (NGS) to identify microRNAs (miRNAs) at the molecular response in CML adult patients receiving TKIs treatment. Specific miRNAs showed significant expression in the treatment response of CML patients and may serve as new therapeutic biomarkers.
Article
Respiratory System
Weifeng Zou, Xiaoqian Wang, Wei Hong, Fang He, Jinxing Hu, Qing Sheng, Tao Zhu, Pixin Ran
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2020)
Article
Environmental Sciences
Zihui Wang, Yumin Zhou, Yongbo Zhang, Xiaoliang Huang, Xianzhong Duan, Duohong Chen, Yubo Ou, Longhui Tang, Shiliang Liu, Wei Hu, Chenghao Liao, Yijia Zheng, Long Wang, Min Xie, Jinzhen Zheng, Sha Liu, Ming Luo, Fan Wu, Zhishan Deng, Heshen Tian, Jieqi Peng, Huajing Yang, Shan Xiao, Xinwang Wang, Nanshan Zhong, Pixin Ran
Summary: In Guangdong, the reduction in PM2.5, PM10, and SO2 concentrations may lead to a decrease in attributable hospital admissions for AECOPD, while ozone (O-3) has emerged as an important risk factor.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Binwei Hao, Ruiting Sun, Xiaotong Guo, Lili Zhang, Jieda Cui, Yumin Zhou, Wei Hong, Yanan Zhang, Jinxi He, Xiaoming Liu, Bing Li, Pixin Ran, Juan Chen
Summary: NOX4-mediated ROS production alters TGF-beta(1) induced cell differentiation and collagen I protein synthesis in HBSMCs through the p38MAPK/Akt signaling pathway in a Smad-dependent manner.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Multidisciplinary Sciences
Zhongfang Wang, Xiaoyun Yang, Jiaying Zhong, Yumin Zhou, Zhiqiang Tang, Haibo Zhou, Jun He, Xinyue Mei, Yonghong Tang, Bijia Lin, Zhenjun Chen, James McCluskey, Ji Yang, Alexandra J. Corbett, Pixin Ran
Summary: The study found virus-specific T-cell memory in COVID-19 patients and close contacts. Patients had stronger T cell responses compared to close contacts. Despite lacking detectable infection, close contacts were able to gain T-cell immunity against SARS-CoV-2.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Huanhuan Fan, Fan Wu, Jing Liu, Weifeng Zeng, Silan Zheng, Heshen Tian, Haiqing Li, Huajing Yang, Zihui Wang, Zhishan Deng, Jieqi Peng, Youlan Zheng, Shan Xiao, Guoping Hu, Yumin Zhou, Pixin Ran
Summary: Individuals with prior pulmonary tuberculosis have an increased risk and high prevalence of chronic obstructive pulmonary disease (COPD). Future studies are needed to identify the underlying mechanisms for tuberculosis-associated COPD and therapeutic strategies.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Toxicology
Jinding Pu, Juan Xu, Lu Chen, Hongbin Zhou, Weitao Cao, Binwei Hao, Naijian Li, Jianxiong Wu, JinZhen Zheng, Wei Hong, Bing Li, Pixin Ran
Summary: Research has shown that biomass smoke exposure may induce Th17 responses through activation of dendritic cells and lead to the development of chronic obstructive pulmonary disease in a rat model. By studying the role of antigen-presenting cells and the effect of biomass-related particulate matter, it was found that biomass smoke activates lung dendritic cells via the Toll-like receptor 2 pathway.
TOXICOLOGY LETTERS
(2021)
Article
Environmental Sciences
Mi Gao, Chunxiao Liang, Wei Hong, Xiaoyuan Yu, Yumin Zhou, Ruiting Sun, Haiqing Li, Haichao Huang, Xuhong Gan, Ze Yuan, Jiahuan Zhang, Juan Chen, Qiudi Mo, Luyao Wang, Biting Lin, Bing Li, Pixin Ran
Summary: Exposure to biomass-related PM2.5 may lead to mitochondrial dysfunction in human airway epithelial cells, resulting in altered mitochondrial metabolism and dynamics. Mitochondria targeted peptide could alleviate these effects.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cardiac & Cardiovascular Systems
Jieqi Peng, Fan Wu, Heshen Tian, Huajing Yang, Youlan Zheng, Zhishan Deng, Zihui Wang, Shan Xiao, Xiang Wen, Peiyu Huang, Lifei Lu, Cuiqiong Dai, Ningning Zhao, Suyin Huang, Pixin Ran, Yumin Zhou
Summary: In a study of 1327 subjects, the prevalence of IOS-SAD in a community-based population was 32.9%, with the IOS-SAD group exhibiting increased airway resistance and poorer lung function compared to the non-SAD group. Risk factors for SAD included older age, higher BMI, smoking, childhood cough, and asthma.
RESPIRATORY MEDICINE
(2021)
Article
Respiratory System
Weifeng Zou, Dong Ye, Sha Liu, Jinxing Hu, Tao Zhu, Fang He, Pixin Ran
Summary: Inhibition of GSK-3 beta weakens the PM2.5-induced inflammatory response by regulating the JNK/NF-kappa B signaling pathway in bronchial epithelial cells. The use of GSK-3 beta inhibitors TDZD-8 and SB216763 significantly suppressed the effects of PM2.5 on inflammation, with TDZD-8 showing greater differences in inflammation-related cytokine levels compared to SB216763. JNK inhibitor SP600125 also reduced the level of NF-kappa B phosphorylation induced by PM2.5.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Medicine, Research & Experimental
Erkang Yi, Weitao Cao, Jiahuan Zhang, Biting Lin, Zihui Wang, Xiaoyu Wang, Ge Bai, Xinyue Mei, ChengShu Xie, Jing Jin, Xinyuan Liu, Haiqing Li, Fan Wu, Zhiwei Lin, Ruiting Sun, Bing Li, Yumin Zhou, Pixin Ran
Summary: This study aims to identify and validate the key genes driving the development of chronic obstructive pulmonary disease (COPD) through bioinformatics analysis and experimental validation. Results revealed a series of potential pathogenic genes of COPD, among which MMP1 was the most likely gene responsible for the progression of COPD. MMP1 is significantly related to inflammatory effects and cilia function in human bronchial epithelial cells.
Article
Oncology
Erkang Yi, Biting Lin, Yi Zhang, Xiaoyu Wang, Jiahuan Zhang, Yu Liu, Jing Jin, Wei Hong, Zhiwei Lin, Weitao Cao, Xinyue Mei, Ge Bai, Bing Bing Li, Yumin Zhou, Pixin Ran
Summary: In this study, it was found that lncRNA HSALR1 is highly correlated with TGF-beta 1 and mainly expressed in human lung fibroblasts. HSALR1 is induced by Smad3 and promotes fibroblast proliferation. Mechanistically, it directly binds to HSP90AB1 protein and acts as a scaffold to stabilize the binding between Akt and HSP90AB1, thereby promoting Akt phosphorylation. In a mouse model simulating COPD, mice expressing HSALR1 showed worse lung function and more pronounced airway remodeling compared to wild type mice. This finding suggests that lncRNA can participate in COPD development, and HSALR1 is a promising molecular target for COPD therapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Respiratory System
Naijian Li, Zhouli Dai, Zhang Wang, Zhishan Deng, Jiahuan Zhang, Jinding Pu, Weitao Cao, Tianhui Pan, Yumin Zhou, Zhaowei Yang, Jing Li, Bing Li, Pixin Ran
Summary: The gut microbiome of COPD patients differs from healthy controls, with distinct microbial diversity, Prevotella-dominated gut enterotype, and lower levels of short-chain fatty acids. Transplantation of fecal microbiota from COPD patients into mice led to elevated lung inflammation, while exposure to biomass fuel smoke exacerbated lung function decline, emphysematous changes, airway remodeling, and mucus hypersecretion in a COPD-like manner.
RESPIRATORY RESEARCH
(2021)
