Review
Biochemistry & Molecular Biology
Chen Yu, Bing Zhao, Yan Li, Hengchang Zang, Lian Li
Summary: This review discusses the current research status of osteoarthritis (OA), the importance of early diagnosis, the potential application of vibrational spectroscopy in OA diagnosis, comparison of various diagnostic methods, and the promising role of vibrational spectroscopy as a tool for early OA diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Ceramics
Brian Topper, Elizabeth M. Tsekrekas, Lucas Greiner, Randall E. Youngman, Efstratios Kamitsos, Doris Moncke
Summary: The structures of glasses in the lithium-bismuth orthoborate composition range show deviation from the short-range order structure of crystalline end-members. The increase in bismuth oxide content leads to an increase in the fraction of tetrahedral boron and a continuous rise in glass transition temperature. However, the glass stability reaches a maximum in the multicomponent glass of x = 40.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Spectroscopy
Jordana Dias Santos, Priscila F. Pinto, Howell G. M. Edwards, Luiz F. Cappa de Oliveira
Summary: Vibrational spectroscopic techniques, such as Raman and infrared spectroscopy, have been increasingly utilized in the analytical studies of hair structures, showing efficiency in analyzing the permeation of cosmetic treatments into the hair fiber. These techniques demonstrated the internal characteristics of the fiber and the diffusion of different cosmetics, proving to be valuable tools for studying cosmetic permeation into the hair fiber and analyzing its external and internal structure.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Endocrinology & Metabolism
Savannah Heath, Yan Han, Rui Hua, Anuradha Roy, Jean Jiang, Jeffry S. Nyman, Xiaodu Wang
Summary: This study demonstrates the ability of Raman spectroscopy to detect changes in GAG content in bone non-destructively. The -1378 cm-1 peak in Raman spectra was found to be sensitive to GAG changes, while the -1070 cm-1 peak was not suitable for detecting GAG changes.
Article
Chemistry, Analytical
Zhongyue Guo, Yeran Bai, Meng Zhang, Lu Lan, Ji-Xin Cheng
Summary: Antimicrobial resistance poses a major threat to global health and economics, necessitating rapid AST methods. We introduce a rapid AST method based on wide-field mid-infrared photothermal imaging, capable of metabolic imaging for hundreds of bacteria at single-cell resolution within seconds. This method enables probing of perturbed microbial protein synthesis within 1 hour after antibiotic treatment in E. coli cells, providing insights into antibiotic susceptibility.
ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Daniel Cozzolino
Summary: Vibrational spectroscopy techniques are widely used in food analysis, especially in the evaluation and quantification of nutraceuticals.
Article
Biochemical Research Methods
Signe H. Ptak, Lee Sanchez, Xavier Frette, Dmitry Kurouski
Summary: Fucoidans are sulfated polysaccharides extracted from brown algae, with various applications in medicine. Raman and Infrared spectroscopies have been found to be effective tools for studying the structure of fucoidans. Additionally, they can help identify impurities in fucoidan extracts that may affect their medicinal quality.
Article
Agriculture, Dairy & Animal Science
Hulya Yaman, Didem P. Aykas, Rafael Jimenez-Flores, Luis E. Rodriguez-Saona
Summary: A rapid and simple method based on vibrational spectroscopic techniques was developed to understand biochemical changes during the ripening process of Turkish white cheese and generate predictive algorithms. The models showed good correlation between predicted values by vibrational spectroscopy and reference values, providing real-time tools for addressing deviations in cheese manufacturing. Portable vibrational spectroscopy units can be used for rapid in-situ monitoring of cheese quality during aging.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Spectroscopy
Karlis Berzins, Samuel D. L. Harrison, Claudia Leong, Sara J. Fraser-Miller, Michelle J. Harper, Aly Diana, Rosalind S. Gibson, Lisa A. Houghton, Keith C. Gordon
Summary: Raman and ATR-FTIR spectroscopy were used to analyze 208 breast milk samples as part of a larger research study. Comprehensive qualitative and quantitative analysis was carried out using chemometric methods, revealing the relationship between macronutrients and sample metadata. The study location and primary food sources were found to have a stronger impact on fat composition than its absolute content, highlighting the limitations and challenges of using spectroscopic techniques for this type of analysis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Physical
Francisco Zaera
Summary: Catalysis in industrial chemical processes has long been studied through various spectroscopic techniques like vibrational and X-ray spectroscopies, allowing for a molecular-level understanding of catalytic mechanisms. These techniques help researchers explore the intricate details of catalytic processes and advancements in the field.
JOURNAL OF CATALYSIS
(2021)
Review
Instruments & Instrumentation
Miia Marika Jansson, Martin Kogler, Sohvi Horkko, Tero Ala-Kokko, Lassi Rieppo
Summary: This review provides an overview of the vibrational spectroscopic techniques, including FTIR and Raman spectroscopy, applied in microbiology during the past decade. The results of this review show that these spectroscopic techniques are promising alternatives to conventional diagnostic approaches, providing label-free and noninvasive bacterial detection, identification, and antibiotic susceptibility testing.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Review
Environmental Sciences
Naifu Jin, Qiuyuan Yang, Kai Yang, Yizhi Song, Aizhong Ding, Yujiao Sun, Guanghe Li, Dayi Zhang
Summary: This article reviews traditional toxicity assays for environmental pollutants and proposes a biosensor-biospectroscopy coupling approach for quantification and source determination of ecotoxicity. The method has the ability to examine toxicity levels and mechanisms, and can be potentially applied in wastewater treatment, environmental remediation, and emergency response.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Medicine, General & Internal
Francesco Vigo, Alessandra Tozzi, Muriel Disler, Alessia Gisi, Vasileios Kavvadias, Tilemachos Kavvadias
Summary: Although spectroscopic techniques have been known since the first half of the twentieth century, their evolution has significantly accelerated after the 2000s due to the development of new computer technologies for analyzing large amounts of data. These techniques are now not limited to analytical chemistry, but are also useful instruments in the medical field. The analysis of urine samples using spectroscopy provides a potential diagnostic tool for early detection of diseases, with its versatility, speed, and ability to obtain a large volume of information.
Article
Biophysics
Rebecca M. Irwin, Tianyu Gao, Alexander J. Boys, Kyla Ortved, Itai Cohen, Lawrence J. Bonassar
Summary: The study found that the interface slope had a stronger correlation with local tissue strains under compressive and shear loading, compared to current histological integration assessments and local compositional measures. Therefore, controlling interface geometry at the time of surgery is important for cartilage repair integration and long-term healing.
JOURNAL OF BIOMECHANICS
(2021)
Article
Chemistry, Physical
Xianze Meng, Xinran Li, Qinhao Zhang, Liankui Wu, Fahe Cao
Summary: In this paper, the structure and evolution of the hydrogen bond network in an aqueous solution simulating the marine environment were studied using molecular simulation and in-situ Raman spectroscopy. The results showed that the hydrogen bond structure in the solution was affected by ions. The enthalpy and entropy change of the hydrogen bond evolution were also calculated. This work lays the foundation for studying life phenomena, physical properties, and chemical reactions in the marine environment.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Charlie Colin-Pierre, Valerie Untereiner, Ganesh D. Sockalingum, Nicolas Berthelemy, Louis Danoux, Vincent Bardey, Solene Mine, Christine Jeanmaire, Laurent Ramont, Stephane Brezillon
Summary: This study utilized infrared spectral imaging (IRSI) to investigate the expression and distribution changes of glypicans in different hair follicle compartments during various phases of the hair growth cycle, providing a new perspective on hair shaft growth. The results demonstrate the capability of IRSI to simultaneously reveal the location of proteins, PGs, GAGs, and sulfated GAGs in hair follicles in a reagent- and label-free manner.
Article
Biochemistry & Molecular Biology
Shaza Ahmed, Hossam Taha Mohamed, Noura El-Husseiny, Manal M. El Mahdy, Gehan Safwat, Ayman A. Diab, Ahmed A. El-Sherif, Mohamed El-Shinawi, Mona Mostafa Mohamed
Summary: Locally advanced breast cancer (LABC) is a challenging disease with low survival rates due to treatment resistance, and the study suggests that the cytokine IL-8 secreted by TAMs may contribute to lapatinib resistance in LABC patients. Therefore, combination therapy to neutralize or block IL-8 action could potentially enhance the response to lapatinib treatment in LABC patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Oncology
Camille Mazza, Vincent Gaydou, Jean-Christophe Eymard, Philippe Birembaut, Valerie Untereiner, Jean-Francois Cote, Isabelle Brocheriou, David Coeffic, Philippe Villena, Stephane Larre, Vincent Vuiblet, Olivier Piot
Summary: Assessing the tumor response to chemotherapy is crucial for improving patient care. In this study, we used infrared spectroscopy to analyze tissue samples from muscle-invasive bladder cancer and developed a classification model to predict the response to chemotherapy. This study highlights the potential of infrared imaging for personalized treatment.
Article
Multidisciplinary Sciences
Moustafa A. Shehata, Julia Contreras, Ana Martin-Hurtado, Aurane Froux, Hossam Taha Mohamed, Ahmed A. El-Sherif, Ivan Plaza-Menacho
Summary: This study investigates the structural and dynamic determinants of highly selective RET kinase inhibition, identifying a new druggable target called the post-lysine pocket. It demonstrates that second generation RET inhibitors exploit this vulnerability, providing important implications for future drug design and personalized therapies for RET-driven cancers.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Hossam Taha Mohamed, Aya Ali El-Sharkawy, Mohamed El-Shinawi, Robert J. Schneider, Mona Mostafa Mohamed
Summary: The secretome of HCMV+ TAMs enhances the proliferation, invasion, colony formation, and BCSC properties of IBC cells by activating the phosphorylation of p-STAT3, p-AMPK alpha, p-PRAS40, and p-SAPK/JNK intracellular signaling molecules.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Romain Rivet, Rajas Mallenahalli Rao, Pierre Nizet, Nicolas Belloy, Louise Huber, Manuel Dauchez, Laurent Ramont, Stephanie Baud, Stephane Brezillon
Summary: This study characterized the structure and dynamics of four SLRPs using in silico 3D modeling, and evaluated their capacity to bind to MMP-14 and regulate its activity. The results demonstrated that each SLRP exhibited significant inhibition of MMP-14 activity, which was related to the core protein conformation as well as the glycan chain structures and dynamics.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hossam Taha Mohamed, Gihan Kamel, Noura El-Husseiny, Aya Ali El-Sharkawy, Ahmed A. El-Sherif, Mohamed El-Shinawi, Mona Mostafa Mohamed
Summary: This study suggests that the pathogenesis of inflammatory breast cancer is related to inflammatory manifestations accompanied by specific cellular and molecular mechanisms in the tumor microenvironment. Tumor-associated macrophages play a significant role in the metastatic process of IBC through the secretion of cytokines. Gene expression signature and SR-mu FTIR were used to study the changes in macrophages stimulated by the secretome of IBC and non-IBC cells, showing significant differences in polarization-related genes and biochemical changes between the two. This research helps to better understand the potential role of TAMs in IBC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Medicine, General & Internal
Alshaimaa Tarek, Hossam Taha Mohamed, Aya Ali El-Sharkawy, Shrouk Khalaf El-Sayed, Jon Mark Hirshon, Wendy A. Woodward, Mohamed El-Shinawi, Mona Mostafa Mohamed
Summary: By comparing the gene expression profiles of matrisome and adhesome in non-IBC and IBC tissues, as well as the secretory inflammatory mediators in patient-derived explants, we found that these genes and cytokines play a significant role in the metastasis of inflammatory breast cancer.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Cell & Tissue Engineering
Charlie Colin-Pierre, Oussama El Baraka, Louis Danoux, Vincent Bardey, Valerie Andre, Laurent Ramont, Stephane Brezillon
Summary: This article reviews the structure, classification, and role of heparan sulfate proteoglycans (HSPGs) in stem cell fate regulation. Specifically, it focuses on hair follicle stem cell fate and the potential use of HSPGs to treat hair loss from dermatological and cosmeceutical perspectives.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Charlie Colin-Pierre, Valerie Untereiner, Ganesh D. Sockalingum, Laurent Ramont, Stephane Brezillon
Summary: The expression of glypicans in different hair follicle (HF) compartments was investigated using infrared spectral imaging (IRSI) for the first time, showing the distribution changes of GPC4 and GPC6 in HFs during different phases of the hair growth cycle. Western blot assays confirmed these findings. IRSI demonstrated its ability to identify the location of proteins, proteoglycans, glycosaminoglycans, and sulfated glycosaminoglycans in HFs in a label-free manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Critical Care Medicine
Auguste Dargent, Hugo Dumargne, Marie Labruyere, Stephane Brezillon, Sylvie Brassart-Pasco, Mathieu Blot, Pierre-Emmanuel Charles, Isabelle Fournel, Jean-Pierre Quenot, Marine Jacquier
Summary: This article aims to review the literature and summarize the current knowledge along these specific axes, as well as methodological aspects related to interstitium exploration.
JOURNAL OF INTENSIVE CARE
(2023)
Meeting Abstract
Oncology
Hossam T. Mohamed, Gihan Kamel, Aya A. El-Sharkawy, Noura El-Husseiny, Mohamed El-Shinawi, Mona M. Mohamed
Meeting Abstract
Oncology
Hossam T. Mohamed, Gihan Kamel, Aya A. El-Sharkawy, Noura El-Husseiny, Mohamed El-Shinawi, Mona M. Mohamed
Meeting Abstract
Oncology
Shaza Ahmed, Nasra F. Abdel Fattah, Shimaa A. Metwally, Marwa A. Abdelwahed, Hossam Taha Mohamed, Sara H. Agwa, AbdelWahab El Ghareeb, Gehan Safwat, Ahmed A. El Sherif, Mohamed M. Moneer, Samah A. Loutfy
Meeting Abstract
Oncology
Shaza Ahmed, Nasra F. Abdel Fattah, Shimaa A. Metwally, Marwa A. Abdelwahed, Hossam Taha Mohamed, Sara H. Agwa, AbdelWahab El Ghareeb, Gehan Safwat, Ahmed A. El Sherif, Mohamed M. Moneer, Samah A. Loutfy