TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway

Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro

(2021) Dai-Chao Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

TREM2, microglia, and Alzheimer’s disease

(2021) Qi Qin et al.   MECHANISMS OF AGEING AND DEVELOPMENT

TREM2 Regulates Heat Acclimation-Induced Microglial M2 Polarization Involving the PI3K-Akt Pathway Following EMF Exposure

(2020) Gen-Lin He et al.   Frontiers in Cellular Neuroscience

Oral treatment with glycyrrhizin inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization after traumatic spinal cord injury

(2020) Xiao-Qiang Su et al.   BRAIN RESEARCH BULLETIN

TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling

(2020) Zhenbang Zhu et al.   PLoS Pathogens

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH

(2020) Weixiang Chen et al.   PHARMACOLOGICAL RESEARCH

Mechanisms of NLRP3 priming in inflammaging and age related diseases

(2020) Anna Gritsenko et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

(2020) Yaping Wang et al.   Journal of Neuroinflammation

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling

(2019) Huiping Long et al.   NEUROCHEMICAL RESEARCH

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

(2019) Rebecca Ward et al.   PHARMACOLOGICAL RESEARCH

Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2

(2019) Qiming Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis

(2019) Zhaofei Wan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

(2019) Sujuan Ding et al.   Biomolecules

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

(2018) Youwen Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Targeting Inflammation in the Prevention and Treatment of Type 2 Diabetes

(2018) Subodh Verma et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

(2018) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

p66Shc Signaling Mediates Diabetes-Related Cognitive Decline

(2018) Yohei Minami et al.   Scientific Reports

LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling

(2018) Li-Qing Wang et al.   Scientific Reports

Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis

(2018) Wenting Qu et al.   Frontiers in Immunology

Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor

(2018) Yuan Li et al.   CURRENT PHARMACEUTICAL DESIGN

Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation

(2017) Filipa I. Baptista et al.   MEDIATORS OF INFLAMMATION

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Exercise and type 2 diabetes: focus on metabolism and inflammation

(2015) Kristian Karstoft et al.   IMMUNOLOGY AND CELL BIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?

(2015) Chen Bing   Adipocyte

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response

(2012) Carmen Correale et al.   GASTROENTEROLOGY

High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways

(2011) Yi Quan et al.   ACTA PHARMACOLOGICA SINICA