Journal
FOODS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/foods10081690
Keywords
microgreens; green pea; Red Rambo radish; LED; Ewing sarcoma; RD-ES; A673; polyphenols
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The study found that pea and radish microgreen extracts have anti-proliferative and pro-apoptotic effects, effectively preventing tumor development. It also showed that Red Rambo radish has anti-tumor effects in RD-ES spheroids, and that pea and radish have good growth quality parameters.
The anti-proliferative/pro-oxidant efficacy of green pea, soybean, radish, Red Rambo radish, and rocket microgreens, cultivated under either fluorescent lighting (predominant spectral peaks in green and orange) or combination light-emitting diode (LED, predominant spectral peak in blue) was investigated using Ewing sarcoma lines, RD-ES and A673, respectively. All aqueous microgreen extracts significantly reduced cell proliferation (cancer prevention effect) to varying extents in two-dimensional sarcoma cell cultures. The effect of the polyphenol fraction in the aqueous food matrix was unrelated to total polyphenol content, which differed between species and light treatment. Only Pisum sativum (LED-grown) extracts exercised anti-proliferative and pro-apoptotic effects in both three-dimensional RD-ES and A673 spheroids (early tumor progression prevention), without cytotoxic effects on healthy L929 fibroblasts. A similar anti-tumor effect of Red Rambo radish (LED and fluorescent-grown) was evident only in the RD-ES spheroids. Aside from the promising anti-tumor potential of the polyphenol fraction of green pea microgreens, the latter also displayed favorable growth quality parameters, along with radish, under both light treatments over the 10 day cultivation period.
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