Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules

(2020) Guanshi Zhang et al.   Metabolomics

2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia

(2020) Susan F. Fitzpatrick et al.   Frontiers in Physiology

Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study

(2020) Brian Kwan et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

(2020) Anne C. Hesp et al.   KIDNEY INTERNATIONAL

Teleological Role of L-2-Hydroxyglutarate Dehydrogenase in the Kidney

(2020) Garrett Brinkley et al.   Disease Models & Mechanisms

Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan

(2020) Jin Seong Hyeon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proximal Tubular Cell–Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis

(2019) Claudia Kruger et al.   DIABETES

NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db/db mice

(2019) Marina Mora-Ortiz et al.   Metabolomics

Metabolomic Changes of Human Proximal Tubular Cell Line in High Glucose Environment

(2019) Pascal Zhongping Wei et al.   Scientific Reports

Improved LC/MS Methods for the Analysis of Metal-Sensitive Analytes Using Medronic Acid as a Mobile Phase Additive

(2018) Jordy J. Hsiao et al.   ANALYTICAL CHEMISTRY

High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase BO-GlcNAcylation

(2018) Diogo de Barros Peruchetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosine methylation predicts renal function decline in American Indians

(2018) Chengxiang Qiu et al.   KIDNEY INTERNATIONAL

Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease

(2018) James A. Shayman   SEMINARS IN NEPHROLOGY

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

(2018) Rémi Longuespée et al.   Acta Neuropathologica Communications

Urine tricarboxylic acid (TCA) cycle metabolites predict progressive chronic kidney disease in type 2 diabetes

(2018) Jian-Jun Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Trace Phosphate Improves ZIC-pHILIC Peak Shape, Sensitivity, and Coverage for Untargeted Metabolomics

(2018) Jonathan L. Spalding et al.   JOURNAL OF PROTEOME RESEARCH

Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model

(2017) Kelli M. Sas et al.   JOURNAL OF LIPID RESEARCH

Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients

(2017) Ling Li et al.   Molecular BioSystems

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2017) Tao Xu et al.   NATURE

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

(2016) Zhuo Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

(2016) Anja Karlstaedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

(2016) Satoshi Miyamoto et al.   EBioMedicine

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

(2016) Ernesto S. Nakayasu et al.   mSystems

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

(2016) Linda A. Gallo et al.   Scientific Reports

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

(2015) Xudong Fu et al.   Cell Metabolism

Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis

(2015) Qing-Yun Cheng et al.   Scientific Reports

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

(2014) Jing Fan et al.   ACS Chemical Biology

Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles

(2014) Kerri J. Grove et al.   JOURNAL OF LIPID RESEARCH

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

(2010) Aaron L. McLain et al.   FREE RADICAL RESEARCH

Mouse Models of Diabetic Nephropathy

(2009) F. C. Brosius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy

(2009) L. M. Russo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

l-2-Hydroxyglutaric aciduria, a disorder of metabolite repair

(2008) E. Van Schaftingen et al.   JOURNAL OF INHERITED METABOLIC DISEASE