Mathematical Model of SARS-Cov-2 Propagation Versus ACE2 Fits COVID-19 Lethality Across Age and Sex and Predicts That of SARS

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review

(2020) Nicholas E. Ingraham et al.   EUROPEAN RESPIRATORY JOURNAL

Decreased Mortality of COVID-19 with Renin-Angiotensin-Aldosterone System Inhibitors Therapy in Patients with Hypertension: A Meta-Analysis

(2020) Xiaoming Guo et al.   HYPERTENSION

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19

(2020) James H Diaz   JOURNAL OF TRAVEL MEDICINE

What would sérgio ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?

(2020) Lucas A.D. Nicolau et al.   MEDICAL HYPOTHESES

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

(2020) Frank L van de Veerdonk et al.   eLife

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 in the lung airways is lower in children compared to adults and increases due to smoking and COPD

(2020) Narjes Saheb Sharif-Askari et al.   Molecular Therapy-Methods & Clinical Development

COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children

(2020) Elena Ciaglia et al.   Frontiers in Pediatrics

The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin–angiotensin system

(2020) Annette Offringa et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

SARS‐CoV‐2 receptorACE2 protein expression in serum is significantly associated with age

(2020) Ana B. Pavel et al.   ALLERGY

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications

(2020) Betty Diamond   JOURNAL OF EXPERIMENTAL MEDICINE

Two hits to the renin‐angiotensin system may play a key role in severe COVID ‐19

(2020) Yu‐Hsin Tseng et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Age-dependent effects in the transmission and control of COVID-19 epidemics

(2020) Nicholas G. Davies et al.   NATURE MEDICINE

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

(2020) Michael R Garvin et al.   eLife

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

(2020) Carl A. Pierce et al.   Science Translational Medicine

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

(2020) Miguel E. Ortiz et al.   EBioMedicine

Distinct disease severity between children and older adults with COVID-19: Impacts of ACE2 expression, distribution, and lung progenitor cells

(2020) Zhao Zhang et al.   CLINICAL INFECTIOUS DISEASES

Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study

(2020) Roberto Pastor-Barriuso et al.   BMJ-British Medical Journal

Counter-regulatory renin–angiotensin system in cardiovascular disease

(2019) Maria Paz Ocaranza et al.   Nature Reviews Cardiology

Can Conformational Changes of Proteins Be Represented in Torsion Angle Space? A Study with Rescaled Ridge Regression

(2019) Ugo Bastolla et al.   Journal of Chemical Information and Modeling

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure

(2018) Ryousuke Satou et al.   CURRENT HYPERTENSION REPORTS

AT2 receptors in cardiovascular and renal diseases

(2017) Elena Kaschina et al.   PHARMACOLOGICAL RESEARCH

A growing microcolony can survive and support persistent propagation of virulent phages

(2017) Rasmus Skytte Eriksen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats

(2016) Laura R. A. Schouten et al.   CRITICAL CARE MEDICINE

Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice

(2016) Hye Eun Yoon et al.   Oxidative Medicine and Cellular Longevity

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

Angiotensin II Mediates Angiotensin Converting Enzyme Type 2 Internalization and Degradation Through an Angiotensin II Type I Receptor–Dependent Mechanism

(2014) Matthew R. Deshotels et al.   HYPERTENSION

Angiotensin II causes imbalance between pro- and anti-inflammatory cytokines by modulating GSK-3β in neuronal culture

(2013) Deepmala Agarwal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis

(2012) D. Caldeira et al.   BMJ-British Medical Journal

Influenza A virus infection kinetics: quantitative data and models

(2011) Amber M. Smith et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The nuclear factor- B-interleukin-6 signalling pathway mediating vascular inflammation

(2010) A. R. Brasier   CARDIOVASCULAR RESEARCH

ACE2 and Diabetes: ACE of ACEs?

(2010) D. Batlle et al.   DIABETES

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

(2009) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

(2008) Yumiko Imai et al.   EXPERIMENTAL PHYSIOLOGY

Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2

(2008) A. C. Mathewson et al.   JOURNAL OF GENERAL VIROLOGY