Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1

(2021) Chunyan Wang et al.   PLoS Pathogens

Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane

(2021) Simon Marlaire et al.   PLoS Pathogens

Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1)

(2021) Nikolaus Dietz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

(2019) Simon Veyron et al.   Nature Communications

Versatility of the BID Domain: Conserved Function as Type-IV-Secretion-Signal and Secondarily Evolved Effector Functions Within Bartonella-Infected Host Cells

(2019) Alexander Wagner et al.   Frontiers in Microbiology

An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMP ylation and de AMP ylation of BiP

(2019) Luke A Perera et al.   EMBO JOURNAL

FIC proteins: from bacteria to humans and back again

(2018) Simon Veyron et al.   Pathogens and Disease

Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella

(2017) Alexander Harms et al.   Genome Biology and Evolution

The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook

(2017) Frédéric V. Stanger et al.   STRUCTURE

Biological Diversity and Molecular Plasticity of FIC Domain Proteins

(2016) Alexander Harms et al.   Annual Review of Microbiology

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification

(2016) Frédéric V. Stanger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin

(2016) Frédéric V. Stanger et al.   PLoS One

Deciphering the Molecular Basis of Functional Divergence in AMPylating Enzymes by Molecular Dynamics Simulations and Structure Guided Phylogeny

(2015) Shradha Khater et al.   BIOCHEMISTRY

Structure and function of Fic proteins

(2015) Craig R. Roy et al.   NATURE REVIEWS MICROBIOLOGY

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

An experimental strategy for the identification of AMPylation targets from complex protein samples

(2014) Kathrin Pieles et al.   PROTEOMICS

The many faces of Fic: structural and functional aspects of Fic enzymes

(2014) Abel Garcia-Pino et al.   TRENDS IN BIOCHEMICAL SCIENCES

An overview of the domestication and impact of theSalmonellamobilome

(2013) Mehari Tesfazgi Mebrhatu et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain

(2013) Valérie Campanacci et al.   EMBO JOURNAL

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold

(2013) Arnaud Goepfert et al.   PLoS One

A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella

(2013) Lionel Guy et al.   PLoS Genetics

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp.

(2012) A. Harms et al.   CLINICAL MICROBIOLOGY REVIEWS

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases

(2012) Feng Feng et al.   NATURE

High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease

(2011) Cassie M. Bryan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Fic domain-catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA

(2011) Dinesh V. Palanivelu et al.   PROTEIN SCIENCE

Parallel Evolution of a Type IV Secretion System in Radiating Lineages of the Host-Restricted Bacterial Pathogen Bartonella

(2011) Philipp Engel et al.   PLoS Genetics

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural basis of Fic-mediated adenylylation

(2010) Junyu Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Fido, a Novel AMPylation Domain Common to Fic, Doc, and AvrB

(2009) Lisa N. Kinch et al.   PLoS One

NCBI BLAST: a better web interface

(2008) M. Johnson et al.   NUCLEIC ACIDS RESEARCH

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE