Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications

(2019) Veymar G. Tacias-Pascacio et al.   Catalysts

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurc™) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer's disease

(2018) Balmiki Ray et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin—Two Main Metabolites of Curcuma longa—in Cancer Cells

(2017) Edna Ooko et al.   Frontiers in Pharmacology

Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells

(2016) Emelia A. Assar et al.   TUMOR BIOLOGY

Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention

(2016) Raúl Martí et al.   Cancers

Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease

(2015) Jin Gao et al.   BEHAVIOURAL BRAIN RESEARCH

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone

(2015) Xuejing Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroprotective effects of macranthoin G from Eucommia ulmoides against hydrogen peroxide-induced apoptosis in PC12 cells via inhibiting NF-κB activation

(2014) Weicheng Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

N -methyl- N -nitrosourea-induced retinal degeneration in mice

(2014) Yuan-yuan Chen et al.   EXPERIMENTAL EYE RESEARCH

Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway

(2014) Jing Wang et al.   INFLAMMATION

Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats

(2014) Bruna Bellaver et al.   TOXICOLOGY IN VITRO

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells

(2013) Mehari Endale et al.   IMMUNOBIOLOGY

Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB

(2013) Xin Zhou et al.   NUTRITION

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation

(2012) Daniel Paris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-Acanthamoebic properties of resveratrol and demethoxycurcumin

(2012) Yousuf Aqeel et al.   EXPERIMENTAL PARASITOLOGY

Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models

(2012) Wonhwa Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Epigallocatechin-3-gallate Inhibits LPS-Induced NF-κB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages

(2012) So-Young Joo et al.   Gut and Liver

Suppression of MAPK and NF-κB Pathways by Limonene Contributes to Attenuation of Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury

(2012) Gefu Chi et al.   INFLAMMATION

Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways

(2012) Liyun Jia et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media

(2012) Julie Marcotorchino et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of TLR2-dependent inflammation in metastatic progression

(2011) Sunhwa Kim et al.   Annals of the New York Academy of Sciences

Salidroside Protects Against Hydrogen Peroxide-Induced Injury in Cardiac H9c2 Cells via PI3K-Akt Dependent Pathway

(2011) Ye Zhu et al.   DNA AND CELL BIOLOGY

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo

(2011) Daniel Paris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant and anti-proliferative properties of lycopene

(2011) Mareike Kelkel et al.   FREE RADICAL RESEARCH

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytesin Vitro

(2011) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation

(2011) Mi-Jeong Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation

(2010) Jiyeon Ock et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Protective Effects of Salidroside on Endothelial Cell Apoptosis Induced by Cobalt Chloride

(2009) Chu-Bing Tan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Preventive and therapeutic anti-inflammatory properties of the sesquiterpene α-humulene in experimental airways allergic inflammation

(2009) Alexandre P. Rogerio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ikappa B kinaseβ/nuclear factor-κB activation controls the development of liver metastasis by way of interleukin-6 expression

(2009) Shin Maeda et al.   HEPATOLOGY

Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia

(2009) Yan Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gallic Acid Suppresses Lipopolysaccharide-Induced Nuclear Factor- B Signaling by Preventing RelA Acetylation in A549 Lung Cancer Cells

(2009) K.-C. Choi et al.   MOLECULAR CANCER RESEARCH

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of cholinesterase and amyloid-β aggregation by resveratrol oligomers fromVitis amurensis

(2008) Moon Hee Jang et al.   PHYTOTHERAPY RESEARCH

E2F – at the crossroads of life and death

(2008) Shirley Polager et al.   TRENDS IN CELL BIOLOGY

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

(2007) Nilesh M. Kalariya et al.   EXPERIMENTAL EYE RESEARCH