Neutrophil in the Pancreatic Tumor Microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a poor prognosis and low survival rates. PDAC is characterized by a fibroinflammatory tumor microenvironment enriched by abundant fibroblasts and a variety of immune cells, contributing to its aggressiveness. Neutrophils are essential infiltrating immune cells in the PDAC microenvironment. Recent studies have identified several cellular mechanisms by which neutrophils are recruited to tumor lesion and promote tumorigenesis. This review summarizes the current understanding of the interplay between neutrophils, tumor cells, and other components in the PDAC tumor microenvironment. The prognosis and therapeutic implications of neutrophils in PDAC are also discussed.

Automated summary

PDAC is a malignancy characterized by poor prognosis and low survival rates, with its aggressive nature attributed to the fibroinflammatory tumor microenvironment enriched by fibroblasts and immune cells, particularly neutrophils. Recent studies have shed light on the cellular mechanisms by which neutrophils are recruited to tumor lesions and promote tumorigenesis, highlighting the importance of understanding the interplay between neutrophils, tumor cells, and other components in the PDAC tumor microenvironment for prognosis and therapeutic implications.