Journal
BIOMOLECULES
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biom11071050
Keywords
mitochondria; antibiotics; unfolded protein response; neurodegeneration; cancer; mitochondrial diseases; obesity; diabetes; muscle fatigue; aging
Categories
Funding
- FIS [PI16/00786, PI19/00377]
- Fondo Europeo de Desarrollo Regional (FEDER Union Europea)
- Spanish Ministry of Education, Culture and Sport
- Regional Ministry of Economic Transformation, Industry, Knowledge and Universities of the Junta de Andalucia [CTS-5725, PY18-850]
- Ayudas para la Formacion de Profesorado Universitario (FPU/MINECO)
- AEPMI (Asociacion de Enfermos de Patologia Mitocondrial)
- ENACH (Asociacion de enfermos de Neurodegeneracion con Acumulacion Cerebral de Hierro)
- FEDER (Federacion Espanola de Enfermedades Raras)
- Fundacion MERCK Salud
- Ministerio de Sanidad, Spain
- European Regional Development Fund (ERDF)
- Yo Nemalinica Association
- KAT6A Association
- Fundacion MEHUER/Colegio Oficial de Farmaceuticos de Sevilla
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The discovery and application of antibiotics have been a major medical advance, but their extensive use has led to global antibiotic resistance. While some studies support the use of antibiotics for treating various diseases, there is controversy over whether the risks associated with antibiotics outweigh their benefits.
The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed.
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