Epigenetics and sarcoidosis

Expression Quantitative Trait Methylation Analysis Reveals Methylomic Associations With Gene Expression in Childhood Asthma

(2020) Soyeon Kim et al.   CHEST

Experimental models of sarcoidosis: where are we now?

(2020) Florence Jeny et al.   CURRENT OPINION IN PULMONARY MEDICINE

Novel protein pathways in development and progression of pulmonary sarcoidosis

(2020) Maneesh Bhargava et al.   Scientific Reports

Association of TGF-β3 and ANXA11 with pulmonary sarcoidosis in Greek population

(2020) Katerina Sikorova et al.   Expert Review of Respiratory Medicine

Current Sarcoidosis Models and the Importance of Focusing on the Granuloma

(2020) Landon W. Locke et al.   Frontiers in Immunology

Sarcoidosis and silica dust exposure among men in Sweden: a case–control study

(2020) Pål Graff et al.   BMJ Open

Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis

(2020) Akira Meguro et al.   Communications Biology

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

(2019) Georgina Mansell et al.   BMC GENOMICS

Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis

(2019) Nicholas K. Arger et al.   RESPIRATORY MEDICINE

Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases

(2019) Philipp Jurmeister et al.   Science Translational Medicine

Emerging phenotypes of sarcoidosis based on 18F-FDG PET/CT: a hierarchical cluster analysis

(2019) Spyros A Papiris et al.   Expert Review of Respiratory Medicine

Income and Other Contributors to Poor Outcomes in US Sarcoidosis Patients

(2019) Logan J Harper et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Gene–Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis

(2019) Natalia V. Rivera et al.   Scientific Reports

Role of epigenetics in the development of childhood asthma

(2018) Elizabeth J. Davidson et al.   Current Opinion in Allergy and Clinical Immunology

Phenotypes of organ involvement in sarcoidosis

(2018) Jonas Christian Schupp et al.   EUROPEAN RESPIRATORY JOURNAL

Familial Aggregation and Heritability of Sarcoidosis: A Swedish Nested Case-Control Study

(2018) Marios Rossides et al.   EUROPEAN RESPIRATORY JOURNAL

Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes

(2018) Caroline E. Broos et al.   EUROPEAN RESPIRATORY JOURNAL

Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis

(2018) Amit Kishore et al.   RESPIROLOGY

Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

(2018) Brandon L. Pierce et al.   Nature Communications

Treatment of sarcoidosis: grading the evidence

(2018) W. Ennis James et al.   Expert Review of Clinical Pharmacology

DNA Methylation Changes in Lung Immune Cells are Associated with Granulomatous Lung Disease

(2018) Ivana V Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transgenerational Epigenetic Inheritance

(2018) Ana Bošković et al.   Annual Review of Genetics

Molecular profiling of regulatory T cells in pulmonary sarcoidosis

(2018) Neli Kachamakova-Trojanowska et al.   JOURNAL OF AUTOIMMUNITY

The environment, epigenome, and asthma

(2017) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices

(2017) Sanjay M. Prakadan et al.   NATURE REVIEWS GENETICS

Associating cellular epigenetic models with human phenotypes

(2017) Tuuli Lappalainen et al.   NATURE REVIEWS GENETICS

De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture

(2017) Michele Di Pierro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences

(2016) Natalia V. Rivera et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IFN-γ–Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

(2016) Joris Ramstein et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Single-Cell (Multi)omics Technologies

(2016) Lia Chappell et al.   Annual Review of Genomics and Human Genetics

Altered miRNA expression in pulmonary sarcoidosis

(2016) Justyna Kiszałkiewicz et al.   BMC Medical Genetics

Overall human mortality and morbidity due to exposure to air pollution

(2016) Lucyna Samek   International Journal of Occupational Medicine and Environmental Health

The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without Löfgren’s Syndrome

(2016) Eva Novosadova et al.   MEDIATORS OF INFLAMMATION

Transcription factors as readers and effectors of DNA methylation

(2016) Heng Zhu et al.   NATURE REVIEWS GENETICS

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

(2016) Aleksandar Vojta et al.   NUCLEIC ACIDS RESEARCH

Seasonal variation in incidence of sarcoidosis: a population-based study, 1976–2013

(2016) Patompong Ungprasert et al.   THORAX

A CRISPR-based approach for targeted DNA demethylation

(2016) Xingxing Xu et al.   Cell Discovery

Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk

(2015) Annegret Fischer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Association ofHLA-DRB1with Sarcoidosis Susceptibility and Progression in African Americans

(2015) Albert M. Levin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription FactorT-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

(2015) Tereza Dyskova et al.   MEDIATORS OF INFLAMMATION

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

ACE and sIL-2R correlate with lung function improvement in sarcoidosis during methotrexate therapy

(2015) Adriane D.M. Vorselaars et al.   RESPIRATORY MEDICINE

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis

(2014) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Blockade of the Programmed Death-1 Pathway Restores Sarcoidosis CD4+T-Cell Proliferative Capacity

(2014) Nicole A. Braun et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Differential Inflammatory MicroRNA and Cytokine Expression in Pulmonary Sarcoidosis

(2014) Agnieszka Jazwa et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type

(2014) Alicia K Smith et al.   BMC GENOMICS

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes

(2014) R. Su et al.   EUROPEAN RESPIRATORY JOURNAL

Efficient Generalized Least Squares Method for Mixed Population and Family-based Samples in Genome-wide Association Studies

(2014) Jia Li et al.   GENETIC EPIDEMIOLOGY

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

(2014) Alex Poole et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice

(2014) Da-Hai Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Identifying and mitigating bias in next-generation sequencing methods for chromatin biology

(2014) Clifford A. Meyer et al.   NATURE REVIEWS GENETICS

Admixture Fine-Mapping in African Americans Implicates XAF1 as a Possible Sarcoidosis Risk Gene

(2014) Albert M. Levin et al.   PLoS One

Sarcoidosis and Chronic Beryllium Disease: Similarities and Differences

(2014) Annyce Mayer et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study

(2014) X. Feng et al.   BMJ Open

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

Interferon-inducible chemokines reflect severity and progression in sarcoidosis

(2013) Robert Su et al.   RESPIRATORY RESEARCH

Measurement of neopterin, TGF-β1and ACE in the exhaled breath condensate of patients with sarcoidosis

(2013) Hasib Ahmadzai et al.   Journal of Breath Research

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation

(2013) Brendan E. Russ et al.   Frontiers in Genetics

Pre-Clinical Studies of Epigenetic Therapies Targeting Histone Modifiers in Lung Cancer

(2013) Kenneth Huffman et al.   Frontiers in Oncology

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans

(2012) A M Levin et al.   GENES AND IMMUNITY

Dual Analysis for Mycobacteria and Propionibacteria in Sarcoidosis BAL

(2012) Kyra A. Oswald-Richter et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Peripheral Blood Gene Expression as a Novel Genomic Biomarker in Complicated Sarcoidosis

(2012) Tong Zhou et al.   PLoS One

Genome-Wide Association Study of African and European Americans Implicates Multiple Shared and Ethnic Specific Loci in Sarcoidosis Susceptibility

(2012) Indra Adrianto et al.   PLoS One

Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease

(2012) Justine A Ellis et al.   Clinical Epigenetics

Sarcoidosis Blood Transcriptome Reflects Lung Inflammation and Overlaps with Tuberculosis

(2011) Laura L. Koth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Differential expression of microRNA and predicted targets in pulmonary sarcoidosis

(2011) Elliott D. Crouser et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

(2011) Matlock Jeffries et al.   Epigenetics

Antigen-specific multifunctional T-cells in sarcoidosis patients with Löfgren’s syndrome

(2011) Maria Wikén et al.   EUROPEAN RESPIRATORY JOURNAL

Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis

(2011) F Mrazek et al.   GENES AND IMMUNITY

DNA Methylation and Demethylation in Mammals

(2011) Zhao-xia Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Set Analysis of Lung Samples Provides Insight into Pathogenesis of Progressive, Fibrotic Pulmonary Sarcoidosis

(2010) Helen E. Lockstone et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Detection of endogenous cytokines in sera or in lymph nodes obtained from patients with sarcoidosis

(2010) M. ASANO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

(2010) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

First independent replication study confirms the strong genetic association of ANXA11 with sarcoidosis

(2010) Y. Li et al.   THORAX

HLA-B8/DR3 in sarcoidosis: Correlation to acute onset disease with arthritis

(2010) EVA HEDFORS et al.   TISSUE ANTIGENS

FoxP3+ Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions

(2009) Cécile Taflin et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis

(2009) Elliott D. Crouser et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunology of chronic beryllium disease

(2009) George Samuel et al.   Current Opinion in Allergy and Clinical Immunology

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis

(2008) Sylvia Hofmann et al.   NATURE GENETICS

Heredity in sarcoidosis: a registry-based twin study

(2008) A Sverrild et al.   THORAX

Phenotyping Sarcoidosis from a Pulmonary Perspective

(2007) Antje Prasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE