Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.706832
Keywords
diabetic kidney disease; mitochondrial quality control; oxidative stress; mitochondrial dynamics; mitophagy; mitochondrial biogenesis; mitochondrial protein quality control
Categories
Funding
- National Natural Science Foundation of China [81800650, 81870500]
- Hunan Provincial Natural Science Foundation for Outstanding Youth [2020JJ2020]
- Major Research and Development Program of Hunan Province [S2020GCZDYF0628]
- Hunan Provincial Clinical Medical Technology Innovation Guide Project [2020SK53402]
- China International Medical Foundation [Z2017242037]
- blood purification center branch of Chinese Hospital Association
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Diabetic kidney disease is a major complication of diabetes mellitus, with a complex pathogenesis involving inflammation, autophagy impairment, and oxidative stress. The loss of mitochondrial quality control plays a critical role in the progression of DKD.
Diabetic kidney disease (DKD) is the predominant complication of diabetes mellitus (DM) and the leading cause of chronic kidney disease and end-stage renal disease worldwide, which are major risk factors for death. The pathogenesis of DKD is very complicated, including inflammation, autophagy impairment, oxidative stress, and so on. Recently, accumulating evidence suggests that the loss of mitochondrial quality control exerts critical roles in the progression of DKD. Mitochondria are essential for eukaryotic cell viability but are extremely vulnerable to damage. The mechanisms of mitochondrial quality control act at the molecular level and the organelle level, including mitochondrial dynamics (fusion and fission), mitophagy, mitochondrial biogenesis, and mitochondrial protein quality control. In this review, we summarize current knowledge of the role of disturbances in mitochondrial quality control in the pathogenesis of DKD and provide potential insights to explore how to delay the onset and development of DKD.
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