Article
Immunology
Junhong Li, Shuxin Zhang, Siliang Chen, Yunbo Yuan, Mingrong Zuo, Tengfei Li, Zhihao Wang, Yanhui Liu
Summary: This study found a relationship between glioma and lipid metabolism and established a risk model based on lipid metabolism-related genes that can effectively predict prognosis in glioma patients. Additionally, the model can stratify patients into different groups with distinct immune characteristics, suggesting that immunotherapy may be beneficial for glioma patients with specific lipid metabolism profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yingming Zhou, Hu Wang, Yi Luo, Biguang Tuo, Xuemei Liu, Taolang Li
Summary: Breast cancer is a common and deadly malignancy worldwide, and the reprogramming of nutrient metabolism in cancer cells plays a crucial role in tumor progression. The abnormal function of immune cells and immune factors in the tumor microenvironment, as well as the crosstalk between immune cells and cancer cells, are key mechanisms in regulating cancer progression. This review summarizes the latest findings on metabolism-related processes in the immune microenvironment during breast cancer progression, providing potential strategies for regulating the immune microenvironment and attenuating breast cancer through metabolic interventions.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Wataru Goto, Shinichiro Kashiwagi, Yuri Kamei, Chika Watanabe, Naoki Aomatsu, Katsumi Ikeda, Yoshinari Ogawa, Kosei Hirakawa, Masaichi Ohira
Summary: Good control of serum lipid metabolism may improve the tumor immune microenvironment and prognosis in postmenopausal HR-positive/HER2-negative breast cancer patients.
Article
Immunology
Lixi Luo, Qun Wei, Chenpu Xu, Minjun Dong, Wenhe Zhao
Summary: This study investigated the role of pyroptosis in the tumor microenvironment of triple-negative breast cancer (TNBC). Through comprehensive analysis of pyroptosis-related genes, two molecular subtypes with different tumor microenvironment characteristics and survival outcomes were identified. A 12-gene score was established to predict short- and long-term overall survival of TNBC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyunho Yoon, Sanghoon Lee
Summary: Lipid metabolism plays a crucial role in the aggressiveness of ovarian cancer, affecting tumor cell proliferation, migration, and immune regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Qianhui Xu, Shaohuai Chen, Yuanbo Hu, Wen Huang
Summary: This study comprehensively investigated the role of immune cell infiltration patterns in tumor progression and clinical outcomes in breast cancer. Different immune infiltration patterns were identified, with high ICI scores suggesting immune-exhausted phenotype and low ICI scores corresponding to immune-activated phenotype with potential immunotherapeutic advantage. The findings contribute to a better understanding of the complexity of the tumor immune microenvironment and could potentially optimize precision immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yaobin Lin, Yu Xiao, Shan Liu, Liang Hong, Lingdong Shao, Junxin Wu
Summary: Lipid metabolism-related lncRNAs can predict the prognosis and tumor microenvironment of colon cancer, and may be important biomarkers relevant to immunotherapy.
BMC MEDICAL GENOMICS
(2022)
Article
Medicine, Research & Experimental
Zhiwen Qian, Lingyan Chen, Jiayu Liu, Ying Jiang, Yan Zhang
Summary: Breast cancer is associated with lipid disorders and PPAR alpha has been found to regulate various processes in cancer cells, including cell cycle and apoptosis, and the tumor microenvironment. PPAR alpha agonists are used as adjuvant therapy for breast cancer, reducing side effects of chemotherapy and enhancing the efficacy of targeted therapy and radiation therapy. However, further research is needed on the role of PPAR alpha agonists in immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Songjiang He, Shi Zhang, Yi Yao, Bin Xu, Zhili Niu, Fuben Liao, Jie Wu, Qibin Song, Minglun Li, Zheming Liu
Summary: Glutamine metabolism is significant in the clinical outcomes of patients with pan-cancer and is closely associated with several hallmarks of a malignant tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Hanxiao Cui, Xueting Ren, Luyao Dai, Lidan Chang, Dandan Liu, Zhen Zhai, Huafeng Kang, Xiaobin Ma
Summary: The study developed a gene signature based on nicotinamide metabolism, which can predict the survival rate, tumor microenvironment, and treatment efficacy in breast cancer patients. The low-risk group showed better clinical outcomes and higher abundance of anti-tumor immunocyte infiltration. This novel gene signature is of great significance in evaluating the prognosis and treatment efficacy in breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
YuanLin Sun, Bin Liu, YuJia Chen, YanPeng Xing, Yang Zhang
Summary: This study investigated the role of lipid metabolism in the prognosis of colorectal cancer (CRC) using metabonomics and transcriptomics. The study developed prognostic signatures and a composite nomogram to predict the outcome of CRC patients. The study also explored the potential relationship between tumor microenvironment and immune infiltration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Lilong Liu, Min Mo, Xuehan Chen, Dongchen Chao, Yufan Zhang, Xuewei Chen, Yang Wang, Nan Zhang, Nan He, Xi Yuan, Honglei Chen, Jing Yang
Summary: A lipid metabolism-related prognostic risk score (LMrisk) was developed to provide new biomarkers and combination therapy strategies for colon cancer immunotherapy. The study found that LMrisk was associated with immune cell infiltration and immunotherapy response. These results were confirmed through in vitro coculture studies, tissue microarray analysis, immunofluorescence staining, and mouse models of colon cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuan Shu, Haiqiang Huang, Minjie Gao, Wenjie Xu, Xiang Cao, Xiaoze Jia, Bo Deng
Summary: Recent evidence suggests that lipid metabolism disorder plays a role in tumor development, but its role in pancreatic cancer is still not well understood. This study investigated the relationship between lipid metabolism characteristics and pancreatic cancer using patient samples from various databases. The findings identified different subtypes of pancreatic cancer and revealed the impact of lipid metabolism-related genes on patient prognosis.
BIOCHEMICAL GENETICS
(2023)
Article
Genetics & Heredity
Lan-Xin Mu, You-Cheng Shao, Lei Wei, Fang-Fang Chen, Jing-Wei Zhang
Summary: This study reveals the relationship between m6A regulators and tumor immune microenvironment in breast cancer and establishes a risk model for predicting tumor occurrence and development. The results show that the modification patterns of m6A regulators can predict patient's stage and prognosis. Furthermore, different m6aRiskscore groups exhibit significant differences in immune microenvironment and survival rate.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Hu Qian, Ting Lei, Yihe Hu, Pengfei Lei
Summary: This study identified two molecular subgroups of osteosarcoma with significantly different survival outcomes. Better prognosis was associated with specific immune characteristics and pathways related to immune response and bone remodeling. A risk model based on lipid metabolism related genes showed potential for accurate survival prediction in osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Zhijie Xu, Jinzhou Huang, Ming Gao, Guijie Guo, Shuangshuang Zeng, Xi Chen, Xiang Wang, Zhicheng Gong, Yuanliang Yan
Summary: RNA molecules are vulnerable to oxidative stress, with 8-oxoG being a promising biomarker for measuring oxidative stress and aging-related diseases. RNA oxidation has significant implications for signaling pathways and gene regulation in aging-related diseases, emphasizing the importance of considering multiple RNA oxidation adducts in research and clinical trials.
Article
Cell Biology
Kuan Hu, Juanni Li, Geting Wu, Lei Zhou, Xiang Wang, Yuanliang Yan, Zhijie Xu
Summary: Chemoresistance is a common limitation in treating glioblastoma multiforme (GBM). The study identified CDKN1A as a key gene upregulated in GBM tissues and cells, with significant prognostic value for GBM patients. Clinical data showed correlations between CDKN1A expression and clinicopathological parameters in GBM patients, while CDKN1A was also found to be involved in AKT-mediated TMZ resistance in glioma cells.
Article
Multidisciplinary Sciences
Zhiyang Zhou, Bi Peng, Juanni Li, Kewa Gao, Yuan Cai, Zhijie Xu, Yuanliang Yan
Summary: Alterations in MEK1 vary among different types of cancer, with distinct clinical implications on patient prognosis. This study provides a comprehensive analysis of MEK1 alterations and clinical significance, highlighting the importance of personalized therapy strategies based on MEK1 status in cancer treatment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jing Wang, Minxiang Lei, Zhijie Xu
Summary: The study revealed the overexpression of PROS1 in PTC, which was significantly correlated with lymph node classification, and knockdown of PROS1 inhibited cell proliferation and migration in PTC cells. This suggests PROS1 as a potential immune-related biomarker for PTC development and prognosis.
Article
Multidisciplinary Sciences
Yuanliang Yan, Qiuju Liang, Zhijie Xu, Qiaoli Yi
Summary: This study demonstrated the potential roles of m(6)A target gene CDC42EP3 in ovarian cancer, confirming its down-regulated expression in ovarian cancer tissues and cells. The lower expression of CDC42EP3 was correlated with poor prognosis in patients with ovarian cancer, and its expression was significantly associated with a diverse range of tumor-infiltrating immune cells.
Article
Multidisciplinary Sciences
Bi Peng, Yuanliang Yan, Zhijie Xu
Summary: In this study, increased expression levels of ALKBH1/2/3/4/7 were found in hepatocellular carcinoma tissues, with high levels of ALKBH4 showing a negative correlation with patient survival and disease progression. The molecular profiles of the AlkB family in HCC were associated with immune cell infiltration and methylation levels.
Article
Immunology
Zhijie Xu, Bi Peng, Qiuju Liang, Xi Chen, Yuan Cai, Shuangshuang Zeng, Kewa Gao, Xiang Wang, Qiaoli Yi, Zhicheng Gong, Yuanliang Yan
Summary: This study investigated the association between differentially expressed lncRNAs and ferroptosis-related genes in HCC, identifying a nine-lncRNA-based prognostic model. The model could be a promising personalized tool for prognosis and immune response prediction in HCC patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yutong Wang, Hui Nie, Zhiming Liao, Xiaoyun He, Zhijie Xu, Jianhua Zhou, Chunlin Ou
Summary: The study found that the high expression of LDHA in colon adenocarcinoma was associated with poor survival in patients, and closely related to the levels of immune cell infiltration. This indicates the important role of LDHA in the tumorigenesis and prognosis of colon adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Geting Wu, Yuanliang Yan, Yuan Cai, Bi Peng, Juanni Li, Jinzhou Huang, Zhijie Xu, Jianhua Zhou
Summary: The AlkB family members exhibit differential expression in lung adenocarcinoma, correlating with immune cell infiltration and DNA methylation. Overexpression of ALKBH2 is associated with poor prognosis in patients with LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yunbin Zhong, Haibo Li, Peiwen Li, Yong Chen, Mengyao Zhang, Zhendong Yuan, Yufang Zhang, Zhijie Xu, Geng Luo, Yuan Fang, Xu Li
Summary: This article summarizes current knowledge on the relationship between tumor drug resistance and exosomes, discussing the potential applications of exosomes as diagnostic biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Xiangyuan Qiu, Xinying Li, Yuanliang Yan, Yuan Cai, Qiuju Liang, Bi Peng, Zhijie Xu, Muzhang Xiao, Fada Xia, Jinwu Peng
Summary: The gene DST plays a crucial role in breast cancer. High expression of DST is associated with favorable prognosis and it can alter immune infiltration, affecting the development of breast cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Xiang Wang, Zhijie Xu, Xinxin Ren, Xi Chen, Qiaoli Yi, Shuangshuang Zeng, Abhimanyu Thakur, Zhicheng Gong, Yuanliang Yan
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Zhiyao He, Lei Yu, Zhijie Xu, Chenyu Sun
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yuanliang Yan, Jinwu Peng, Qiuju Liang, Xinxin Ren, Yuan Cai, Bi Peng, Xi Chen, Xiang Wang, Qiaoli Yi, Zhijie Xu
Summary: This review summarizes the significant implications of the interaction between m6A and ncRNAs in various types of cancers, including cancer pathogenesis, therapeutic resistance, and immune regulation. It also highlights the relevance of this interaction in cancer immunotherapeutic procedures and the computation tools for m6A methylome identification among ncRNAs.