Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells

KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1

(2020) Jian-Bin Ma et al.   Cell Death & Disease

PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models

(2020) Umberto Tosi et al.   Science Advances

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

(2020) Soniya Bastola et al.   Nature Communications

Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells

(2019) Halina Was et al.   Clinical Epigenetics

The p53 mRNA: an integral part of the cellular stress response

(2019) Lucia Haronikova et al.   NUCLEIC ACIDS RESEARCH

p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death

(2019) Maria Mrakovcic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma

(2019) Ekaterina Pak et al.   NEURO-ONCOLOGY

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells

(2019) Graham MacLeod et al.   Cell Reports

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

(2019) Monica Fedele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NFAT2-HDAC1 signaling contributes to the malignant phenotype of glioblastoma

(2019) Yifu Song et al.   NEURO-ONCOLOGY

Live Cell Imaging Supports a Key Role for Histone Deacetylase as a Molecular Target during Glioblastoma Malignancy Downgrade through Tumor Competence Modulation

(2019) Aline Menezes et al.   Journal of Oncology

Histone deacetylase 1 promotes glioblastoma cell proliferation and invasion via activation of PI3K/AKT and MEK/ERK signaling pathways

(2018) Shun Li et al.   BRAIN RESEARCH

pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma

(2018) Kyle T. Householder et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness

(2018) Gi-Cheon Kim et al.   Oncogenesis

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis

(2017) Julian Musa et al.   Cell Death & Disease

Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells

(2017) Xiao-Qiang Wang et al.   Oncotarget

Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome

(2017) Konstantin Masliantsev et al.   Oncotarget

Advances in epigenetic glioblastoma therapy

(2017) Dong Hoon Lee et al.   Oncotarget

Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway

(2017) Shiv K. Singh et al.   Cell Reports

Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents

(2016) Hao Cheng et al.   AAPS Journal

Silencing of histone deacetylase 2 suppresses malignancy for proliferation, migration, and invasion of glioblastoma cells and enhances temozolomide sensitivity

(2016) Zhiqiang Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines

(2016) Zong-yang Li et al.   NEUROCHEMICAL RESEARCH

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Causal Mechanistic Regulatory Network for Glioblastoma Deciphered Using Systems Genetics Network Analysis

(2016) Christopher L. Plaisier et al.   Cell Systems

C/EBPβ Mediates TNF-α-Induced Cancer Cell Migration by Inducing MMP Expression Dependent on p38 MAPK

(2015) Peiyi Xia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Gene Expression Mapping of Histone Deacetylases and Co-factors and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas

(2015) Nassim Dali-Youcef et al.   Scientific Reports

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

(2015) Chad M. Toledo et al.   Cell Reports

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

(2014) A. Hagelkruys et al.   DEVELOPMENT

An Amino Terminal Phosphorylation Motif Regulates Intranuclear Compartmentalization of Olig2 in Neural Progenitor Cells

(2014) D. H. Meijer et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience

(2014) Pavel Bezecny   MEDICAL ONCOLOGY

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells

(2013) Ming-Tsang Chiao et al.   Autophagy

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Neuregulin 1 Enhances Cell Adhesion Molecule L1 Expression in Human Glioma Cells and Promotes Their Migration as a Function of Malignancy

(2013) Wei-Jiang Zhao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CSF1 Is a Novel p53 Target Gene Whose Protein Product Functions in a Feed-Forward Manner to Suppress Apoptosis and Enhance p53-Mediated Growth Arrest

(2013) Gregory Azzam et al.   PLoS One

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

A miRNA-regulatory network explains how dysregulated miRNAs perturb oncogenic processes across diverse cancers

(2012) C. L. Plaisier et al.   GENOME RESEARCH

Unknown

(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

(2012) Laura Icardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

(2011) Shwetal Mehta et al.   CANCER CELL

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis

(2011) Jennifer Jurkin et al.   CELL CYCLE

A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03

(2011) Fabio M. Iwamoto et al.   NEURO-ONCOLOGY

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

(2011) C.-I. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dlx5 and Dlx6 Regulate the Development of Parvalbumin-Expressing Cortical Interneurons

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

(2010) O. M. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 using Positron Emission Tomography

(2009) Jacob M. Hooker et al.   ACS Chemical Neuroscience

STAT3 Regulation of Glioblastoma Pathogenesis

(2009) Nuria la Iglesia et al.   CURRENT MOLECULAR MEDICINE

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research

(2009) S. Madhavan et al.   MOLECULAR CANCER RESEARCH

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution

(2008) S. Ray et al.   NUCLEIC ACIDS RESEARCH