Article
Anesthesiology
Thibault Martinez, Gregoire Liaud-Laval, Philippe Laitselart, Matthieu Pissot, Anne Chrisment, Pauline Ponsin, Olivier Duranteau, Stephane De Rudnicki, Mathieu Boutonnet, Nicolas Libert
Summary: This study found an association between traumatic rhabdomyolysis and liver dysfunction in severely injured patients. Intense rhabdomyolysis was associated with a higher incidence of liver failure, as well as renal dysfunction and sepsis.
ANESTHESIA AND ANALGESIA
(2023)
Article
Immunology
Jingyi Wang, Xi Zheng, Yijia Jiang, Huimiao Jia, Xiaocui Shi, Yue Han, Qingping Li, Wenxiong Li
Summary: The study revealed increased expressions of PD-1 and PD-L1 in kidneys after renal ischemia-reperfusion injury, suggesting their essential roles in acute kidney injury (AKI) development. sPD-1 and sPD-L1 can indirectly reflect the expressions of PD-1 and PD-L1 in kidneys, showing excellent predictive abilities for AKI in high-risk patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Myocardial infarction (MI) is a leading cause of death worldwide, and oxidative stress, inflammation, and mitochondrial dysfunction are recognized as possible mechanisms in the development of MI. Different types of programmed cell death (PCDs), including apoptosis, necroptosis, ferroptosis, and pyroptosis, have been associated with different phases of ischemic injury following MI. However, it is still unknown which types of PCDs play the most dominant role in post-MI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Physical
Qi Meng, Binbin Ding, Ping'an Ma, Jun Lin
Summary: Programmed cell death (PCD) and immunogenic cell death (ICD) are important mechanisms in cancer therapy, and understanding their relationship is significant for tumor treatments. This review describes the interrelationship between PCD and ICD using nanomedicines as examples. It provides an overview of PCD patterns, explores the link between apoptosis and ICD, introduces non-apoptotic signaling pathways and their relationship with ICD, and summarizes the potential application of PCD and ICD in the development of new nanomaterials. The review aims to deepen understanding, extend biomedical applications, and promote progress in clinical tumor therapy.
Review
Cell Biology
Elizabeth G. Ames, Jess G. Thoene
Summary: Cystinosis is a lethal genetic disease with specific treatments. The cellular mechanisms are still unknown, but programmed cell death and apoptosis may be involved. Studies have shown that apoptosis rate is increased in cystinosis, but can be partially reversed with cysteamine.
Review
Biochemistry & Molecular Biology
Emma C. Tovey Crutchfield, Sarah E. Garnish, Joanne M. Hildebrand
Summary: Necroptosis is an inflammatory form of cell death evolved to defend against pathogens. Small molecules targeting RIPK1 kinase activity have shown promise in disease models, triggering significant investment in necroptosis blocking drugs. Understanding the role of MLKL in murine disease models is crucial for identifying human indications for targeted drug therapies.
Article
Oncology
Liying Yang, Wei Zhang, Jujie Sun, Guanqun Yang, Siqi Cai, Fenghao Sun, Ligang Xing, Xiaorong Sun
Summary: This study investigated the relationship between the spatial interaction of PD-L1-positive tumor cells and T cells with specific functions and the recurrence of NSCLC, and optimized prognostic stratification. It was found that the number of PD-L1-positive tumor cells was higher in the tumor center compared to the invasion margin, while the number of T cells, especially PD-1-positive CD8 T cells, was lower. The proximity between CD8 T cells and PD-L1-positive tumor cells was closer, especially for exhausted CD8 T cells. The density and percentage of PD-1-positive CD4 T cells interacting with PD-L1-positive tumor cells were associated with recurrence, with increasing risk. Patients with low PD-1-positive CD4 count and high PD-1-positive CD4 density had a significantly higher risk of recurrence. The spatial proximity assessment of PD-1/PD-L1 contributes to a better understanding of tumor immune escape and provides prognostic information for NSCLC patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Editorial Material
Microbiology
Maisem Laabei, Seana Duggan
Summary: Programmed cell death (PCD) and carbohydrate metabolism by-product transport both involve the cidABC and lrgAB operons in Staphylococcus aureus. New research shows that CidA and LrgA function as holins to support endolysin-induced lysis and also facilitate pyruvate uptake during microaerobic and anaerobic growth.
Article
Oncology
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Juha P. Vayrynen, Fredrik Yannopoulos, Olli Helminen
Summary: The study found that CD3(+) and CD8(+) T-cell density and PD-1/PD-L1 expression have prognostic value in pulmonary metastases of colorectal cancer. T-cell infiltration is higher in pulmonary metastases compared to primary tumors. High CD3(+) and CD8(+) cell density are associated with better survival, while high PD-L1 expression is associated with favorable prognosis.
Article
Urology & Nephrology
Qin Yang, Li Gao, Xiao-wei Hu, Jia-nan Wang, Yao Zhang, Yu-hang Dong, Hui Yao Lan, Xiao-ming Meng
Summary: This study investigated the role of Smad3 in cisplatin-induced acute kidney injury, showing that disruption of Smad3 attenuated kidney injury, inflammation, and oxidative stress. Smad3-targeted therapy protected against loss of renal function, apoptosis, necroptosis, inflammation, and oxidative stress in cisplatin nephropathy, suggesting Smad3 as a potential therapeutic target for acute kidney injury.
Article
Biochemistry & Molecular Biology
Elif Kubat Oktem
Summary: The study identifies prefrontal brain biomarkers associated with programmed cell death (PCD) and aging, which could lead to improved therapeutic techniques for age-related neurodegenerative diseases.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Haifeng Yin, Xiaoyun Guo, Yi Chen, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Rachel Steinmetz, Qinghang Liu
Summary: Mutations in TAB2 gene are associated with dilated cardiomyopathy and/or congenital heart disease, by regulating myocardial homeostasis and remodeling through suppressing RIPK1-dependent apoptosis and necroptosis. Deletion of Tab2 in mice leads to dilated cardiomyopathy with massive apoptotic and necroptotic cell death, which can be rescued by inhibiting RIPK1 activation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Plant Sciences
Purva Karia, Keiko Yoshioka, Wolfgang Moeder
Summary: TTM1 is specifically involved in senescence induced by ABA, and its function and turnover are regulated by multiple MAP kinases, with phosphorylation of Ser437 being essential for its function in senescence. Multiple MAP kinases mark TTM1 for protein turnover by phosphorylating Ser10 and Ser490 as well, preventing uncontrolled cell death. This study reveals a novel link between mitochondria and PCD during senescence-associated cell death.
Article
Oncology
Javier Arranz-Nicolas, Miguel Martin-Salgado, Irene Adan-Barrientos, Rosa Liebana, Maria del Carmen Moreno-Ortiz, Judith Leitner, Peter Steinberger, Antonia Avila-Flores, Isabel Merida
Summary: Our study revealed that DGK alpha contributes to the PD-1/PD-L1 axis, restricting the Ras/ERK/AP-1 pathway. Its function reinforces exhausted T cell phenotypes, promoting tumor growth and systemic immunosuppression. Pharmacological DGK alpha inhibition selectively enhances AP-1 transcription and cooperates with antibodies blocking the PD-1/PD-L1 interaction.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Engineering, Environmental
Ruyi Qian, Hongcheng Zhao, Xin Liang, Nan Sun, Nan Zhang, Xianyong Lin, Chengliang Sun
Summary: In this study, we investigated the relationship between autophagy and programmed cell death (PCD) in wheat roots under indium stress. Our results suggest that autophagy suppresses indium-induced PCD in wheat roots.
JOURNAL OF HAZARDOUS MATERIALS
(2022)