The landscape of driver mutations in cutaneous squamous cell carcinoma

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

(2020) Marta Rodríguez-Martínez et al.   CELL

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

(2020) Andrew L. Ji et al.   CELL

The genomic landscapes of individual melanocytes from human skin

(2020) Jessica Tang et al.   NATURE

Selection of oncogenic mutant clones in normal human skin varies with body site

(2020) Joanna C Fowler et al.   Cancer Discovery

Tumor mutational burden (TMB) standardization initiatives: Recommendations for consistent TMB assessment in clinical samples to guide immunotherapy treatment decisions

(2019) Albrecht Stenzinger et al.   GENES CHROMOSOMES & CANCER

Local Determinants of the Mutational Landscape of the Human Genome

(2019) Abel Gonzalez-Perez et al.   CELL

Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution

(2018) A. Hunter Shain et al.   CANCER CELL

PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

(2018) Michael R. Migden et al.   NEW ENGLAND JOURNAL OF MEDICINE

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

(2018) Peng Mao et al.   Nature Communications

Update on Keratinocyte Carcinomas

(2018) Kishwer S. Nehal et al.   NEW ENGLAND JOURNAL OF MEDICINE

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa

(2018) Raymond J. Cho et al.   Science Translational Medicine

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

(2018) Gareth J. Inman et al.   Nature Communications

Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer

(2017) Jason E. Duex et al.   MOLECULAR CANCER RESEARCH

Accelerating Discovery of Functional Mutant Alleles in Cancer

(2017) Matthew T. Chang et al.   Cancer Discovery

The Treatment of Actinic Keratoses—The Rule Rather Than the Exception

(2017) Bobbak Mansouri et al.   JAMA Dermatology

Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis

(2016) Z. Jiyad et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Differential mutation frequencies in metastatic cutaneous squamous cell carcinomas versus primary tumors

(2016) Ayse Selen Yilmaz et al.   CANCER

Nucleotide excision repair is impaired by binding of transcription factors to DNA

(2016) Radhakrishnan Sabarinathan et al.   NATURE

Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes

(2016) Dilmi Perera et al.   NATURE

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

(2016) Patrizia Cammareri et al.   Nature Communications

Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

(2016) Vida Chitsazzadeh et al.   Nature Communications

CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing

(2016) Eric Talevich et al.   PLoS Computational Biology

Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma

(2015) Y. Y. Li et al.   CLINICAL CANCER RESEARCH

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway

(2015) A Hunter Shain et al.   NATURE GENETICS

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

(2014) C. R. Pickering et al.   CLINICAL CANCER RESEARCH

Trends of Keratinocyte Carcinoma Mortality Rates in the United States as Reported on Death Certificates, 1999 Through 2010

(2014) Wesley Wu et al.   DERMATOLOGIC SURGERY

NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis

(2014) Andrew P. South et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma

(2014) Carolyn S Lee et al.   NATURE GENETICS

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

UV Signature Mutations

(2014) Douglas E. Brash   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes

(2014) Christina L. Zheng et al.   Cell Reports

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012

(2013) Pritesh S. Karia et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

(2013) A. Hunter Shain et al.   PLoS One

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Raising the bar for melanoma cancer gene discovery

(2012) A. H. Shain et al.   Pigment Cell & Melanoma Research

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal Dissection of Tumorigenesis in Primary Cancers

(2011) Steffen Durinck et al.   Cancer Discovery

MutantCHUKand Severe Fetal Encasement Malformation

(2010) Jenni Lahtela et al.   NEW ENGLAND JOURNAL OF MEDICINE

PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients

(2008) C A Harwood et al.   BRITISH JOURNAL OF CANCER