Article
Environmental Sciences
Chusheng Liu, Yanjing Wang, Gaofei Zhang, Xuebin Pang, Jiao Yan, Xiaoou Wu, Yingheng Qiu, Ping Wang, Houshuang Huang, Xiaowei Wang, Haiyuan Zhang
Summary: This study discovered various shapes of gold nanomaterials in commercial cosmetics and investigated their toxicity on the skin, finding that embedding these materials in cosmetics can alleviate their toxic effects.
Article
Chemistry, Multidisciplinary
Yuri Park, Soyeon Shin, Nutan Shukla, Kibeom Kim, Myoung-Hwan Park
Summary: Dermal delivery is a non-invasive and simple method that has attracted attention. However, overcoming the skin barrier remains a challenge, and green chemistry is crucial in the cosmetic industry. This study provides a new method using nanobubbles to enhance dermal delivery effects.
Review
Chemistry, Inorganic & Nuclear
Shadpour Mallakpour, Elham Nikkhoo, Chaudhery Mustansar Hussain
Summary: Metal-organic frameworks (MOFs) have gained attention for their adjustable pore sizes, large surface area, and various functionalities, making them suitable for applications in energy storage, CO2 adsorption, catalysis, drug storage, and release.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Lucia Salvioni, Lucia Morelli, Evelyn Ochoa, Massimo Labra, Luisa Fiandra, Luca Palugan, Davide Prosperi, Miriam Colombo
Summary: The role of cosmetic products in society is evolving rapidly, with the importance of personal wellness contributing to their increasing use. This necessitates a detailed explanation of the use of nanoparticles in cosmetics. Nanotechnology has been shown to improve the performance of cosmetics in various ways, particularly in skincare, and despite concerns about nanoparticle toxicity, there are detailed examples of nanocosmetic products with investigated safety.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Environmental Sciences
Oddny Ragnarsdottir, Mohamed Abou-Elwafa Abdallah, Stuart Harrad
Summary: PFAS are known contaminants of indoor dust, but their dermal penetration potential is not well understood. This study assessed the bio-accessibility of 17 PFAS from indoor dust to synthetic human sweat sebum mixtures and found that commonly applied cosmetics significantly impacted the dermal bioaccessibility of PFAS.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Oddny Ragnarsdottir, Mohamed Abou-Elwafa Abdallah, Stuart Harrad
Summary: This study assessed the bioaccessibility of PFAS from indoor dust to synthetic human sweat sebum mixtures (SSSM) using in vitro tests. The composition of the SSSM significantly affected the bioaccessibility of all target compounds. Common cosmetics were found to impact the dermal bioaccessibility of PFAS. The findings highlight the potential substantial contribution of dermal exposure to human body burdens of PFAS and the need for further consideration of this pathway in risk assessment studies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Dermatology
Tae Gon Kim, Yoonjin Lee, Min Seo Kim, Jaehong Lim
Summary: This study aims to improve the efficacy of dermal treatment by loading active ingredients onto natural siliceous spicules. The results show that the ingredients loaded on the spicules can enhance the absorption and penetration rate of the skin, with a simple diffusion release pattern. This novel dermal delivery system has the potential to improve the efficacy of biologically active ingredients.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Theodora Karamanidou, Vasileios Bourganis, Glykeria Gatzogianni, Alexander Tsouknidas
Summary: Literature has suggested the use of metallic nanomaterials in cosmetic products, but due to their nano-scale, special regulations and risk assessments are necessary. Unauthorized metallic NMs in cosmetic products are a concern in the EU market, highlighting the need for stricter regulation and risk assessment processes.
Review
Engineering, Biomedical
Shuai Zha, Ka-Leung Wong, Angelo H. All
Summary: Intranasal delivery of nanoparticles offers a non-invasive and effective method for delivering therapeutic agents to the brain, bypassing the blood-brain barrier.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Environmental
Ovokeroye A. Abafe, Stuart Harrad, Mohamed Abou-Elwafa Abdallah
Summary: In this study, an invitro physiologically based extraction test was used to investigate the dermalbioaccessibility of PBDEs and HBCDDs in different types of microplastics. The dermal bioaccessibility of PBDEs was significantly higher in polyethylene MPs compared to polypropylene MPs. The size of MP particles and the presence of cosmetic formulations influenced the bioaccessibility of PBDEs and HBCDDs. Human exposure to these chemicals via dermal contact with MPs was found to be substantial and the dermal pathway was identified as a major route of exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Radrezza, Gilda Aiello, Giovanna Baron, Giancarlo Aldini, Marina Carini, Alfonsina D'Amato
Summary: The study integrated lipidomics and proteomics analyses to investigate the effects of LMW-HA on normal human dermal fibroblasts, showing significant impact on skin hydration and repair processes. The results revealed 25 nodes covering various intra- and extra-cellular functions, providing valuable insights for further research and formulation improvements.
Review
Chemistry, Physical
Ana Parra, Ivana Jarak, Ana Santos, Francisco Veiga, Ana Figueiras
Summary: Polymeric micelles in nanotechnology have many advantages in cutaneous application, such as increased bioavailability of drugs, greater efficacy even at lower doses, and selective drug delivery in specific organelles, while reducing many adverse effects, which can help improve patient compliance with treatment.
Article
Environmental Sciences
Xia Lin, Yudong Xing, Huijun Chen, Yan Zhou, Xin Zhang, Peng Liu, Jiaoyang Li, Hian Kee Lee, Zhenzhen Huang
Summary: In this study, cosmetic samples from China were analyzed for per-and polyfluoroalkyl substances (PFAS). PFAS were found in all samples, including cosmetics marketed for pregnant women. Short-chain perfluorinated carboxylic acids were the dominant compounds, and perfluorobutanoic acid was the major PFAS in cosmetics for pregnant women. Three emerging PFAS were also identified in quantifiable levels. The study suggested that plastic containers and precursor substances may be sources of PFAS in cosmetics, and aging of products may increase PFAS levels. Although the health risks from dermal exposure were deemed acceptable, the cumulative effect of long-term exposure needs greater attention.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Bianca Hazt, Gabriela Pereira Parchen, Lilian Fernanda Martin do Amaral, Patricia Rondon Gallina, Sandra Martin, Odinei Hess Goncalves, Rilton Alves de Freitas
Summary: Pickering emulsions, stabilized by solid particles instead of molecular or classical surfactants, provide long-term stability against emulsion coalescence. They are environmentally and skin-friendly, offering new sensorial experiences. Besides conventional oil-in-water emulsions, unconventional multiple, oil-in-oil, and water-in-water emulsions have great potential for various applications in pharmaceutical and cosmetic products, such as oil-free systems, permeation enhancers, and topical drug delivery agents. However, despite their potential, commercial products of these Pickering emulsions are not yet available. This review discusses important aspects such as phase behavior, particle properties, rheology, sensorial perception, and current development trends of these emulsions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yingtong Luo, Hanglong Wu, Xuan Zhou, Jianhong Wang, Suleyman Er, Yudong Li, Pascal L. W. Welzen, Roy A. J. F. Oerlemans, Loai K. E. A. Abdelmohsen, Jingxin Shao, Jan C. M. van Hest
Summary: Functionalized polymer vesicles with photothermal-responsive properties have been designed using a new strategy based on near-infrared (NIR) light activation. The resulting vesicles inherit the high photothermal performance of the photothermal agent and maintain their structure and properties after laser irradiation. These polymer vesicles also demonstrate significant loading capacity for hydrophobic and hydrophilic cargos, making them suitable for synergistic therapy in anticancer treatment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Andrea Perrelli, Parisa Fatehbasharzad, Valerio Benedetti, Chiara Ferraris, Marco Fontanella, Elisa De Luca, Mauro Moglianetti, Luigi Battaglia, Saverio Francesco Retta
Summary: Cerebrovascular diseases encompass a variety of brain vasculature disorders and are major causes of mortality and disability worldwide. They can be inherited, with common pathogenetic roles of oxidative stress and inflammation. Nanomedicine strategies may offer innovative features for early detection and treatment of such diseases.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Neurosciences
Luca Zanin, Giorgio Saraceno, Giulia Renisi, Liana Signorini, Luigi Battaglia, Marco Ferrara, Francesco Antonio Rasulo, Pier Paolo Panciani, Marco Maria Fontanella
Summary: This case report describes the delayed onset cell-mediated encephalitis caused by COVID-19 virus, which is the first recorded case occurring more than 40 days after the diagnosis. The patient experienced intense headache, fever, and subsequent generalized epileptic seizures before being diagnosed with brain death.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Elisabetta Muntoni, Laura Anfossi, Paola Milla, Elisabetta Marini, Chiara Ferraris, Maria T. Capucchio, Elena Colombino, Lorena Segale, Massimo Porta, Luigi Battaglia
Summary: The study found limitations in oral administration of insulin, but promising potential for solid oral dosage forms as glucose-lowering agents, especially effective in healthy rats.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Pharmacology & Pharmacy
Itziar Gomez-Aguado, Julen Rodriguez-Castejon, Marina Beraza-Millor, Monica Vicente-Pascual, Alicia Rodriguez-Gascon, Sara Garelli, Luigi Battaglia, Ana del Pozo-Rodriguez, Maria Angeles Solinis
Summary: Developed mRNA-SLN-based nanosystems showed high transfection efficiency and IL-10 expression in treating corneal inflammation. Nanovectors with a mean particle size between 94 and 348 nm and a positive superficial charge were formulated as eye drops containing 1% PVA. After three days of topical administration to mice, all formulations produced GFP in the corneal epithelium.
Review
Pharmacology & Pharmacy
Luigi Battaglia, Anna Scomparin, Chiara Dianzani, Paola Milla, Elisabetta Muntoni, Silvia Arpicco, Roberta Cavalli
Summary: Cutaneous melanoma is an aggressive solid tumor with low survival rates, and current clinical treatments include various methods such as surgery, chemotherapy, immunotherapy, and targeted therapy. Nanotechnology-based delivery systems play a crucial role in improving therapeutic efficacy, especially in combination therapy. Italian researchers are focusing on developing nanoformulations for malignant melanoma therapy and there are numerous nanomedicines undergoing clinical trials in the country.
Article
Chemistry, Multidisciplinary
Chiara Monge, Ian Stoppa, Chiara Ferraris, Annalisa Bozza, Luigi Battaglia, Luigi Cangemi, Gianluca Miglio, Stefania Pizzimenti, Nausicaa Clemente, Casimiro Luca Gigliotti, Elena Boggio, Umberto Dianzani, Chiara Dianzani
Summary: This study presents a preclinical-level test of a multi-pronged approach that inhibits melanoma growth by loading immunotherapeutic, targeted, and chemotherapeutic agents into a nanoemulsion. The approach involves the immune system and has shown promising results in subcutaneous melanoma mouse models. If translated to humans, it could achieve therapeutic efficacy without increasing the risk of toxic effects.
Review
Pharmacology & Pharmacy
Elena Boggio, Casimiro Luca Gigliotti, Ian Stoppa, Deepika Pantham, Sara Sacchetti, Roberta Rolla, Margherita Grattarola, Chiara Monge, Stefania Pizzimenti, Umberto Dianzani, Chiara Dianzani, Luigi Battaglia
Summary: The limitations of chemotherapy are side effects and drug resistance. Loading different anti-tumor drugs in nanocarriers can enhance efficacy and reduce toxicity. Nanomedicines can synergize with pharmacological, immunological, and physical combined treatments, and should be integrated in multimodal combination therapy regimens. The manuscript provides understanding and considerations for developing new nanomedicines and nanotheranostics.
Article
Pharmacology & Pharmacy
Federica Foglietta, Annalisa Bozza, Chiara Ferraris, Luigi Cangemi, Valentina Bordano, Loredana Serpe, Katia Martina, Loretta Lazzarato, Stefania Pizzimenti, Margherita Grattarola, Marie Angele Cucci, Chiara Dianzani, Luigi Battaglia
Summary: Despite advancements in cancer genomic and immunotherapies, advanced melanoma remains a life-threatening disease. In order to improve targeted drug delivery to the tumor, injectable lipid nanoemulsions were functionalized with proteins using two different approaches: chemically grafting transferrin for active targeting, and wrapping cancer cell membrane fragments for homotypic targeting. Protein functionalization was successful in both cases. Preliminary studies using flow cytometry showed that cell-membrane-fragment-wrapped nanoemulsions had higher cell uptake compared to uncoated nanoemulsions. However, transferrin grafting had a less pronounced effect in serum-enriched medium, possibly due to competition with endogenous proteins. Moreover, a more significant internalization was achieved when a pegylated heterodimer was used for conjugation (p < 0.05).
Article
Biochemistry & Molecular Biology
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta
Summary: This study investigated the therapeutic effects of multidrug-loaded lipid nanoemulsions in rescuing the pathological phenotype of CCM disease. The results showed that drug-loaded lipid nanoemulsions can rescue antioxidant responses, reactivate autophagy, and reduce the effect of pro-angiogenic factors better than the free drugs. This highlights the importance of developing a combinatorial preventive and therapeutic approach for CCM.
Article
Pharmacology & Pharmacy
Francesca Della Sala, Assunta Borzacchiello, Chiara Dianzani, Elisabetta Muntoni, Monica Argenziano, Maria Teresa Capucchio, Maria Carmen Valsania, Annalisa Bozza, Sara Garelli, Maria Di Muro, Franco Scorziello, Luigi Battaglia
Summary: Solid lipid nanoparticles promote skin hydration by occluding the stratum corneum and reinforcing the skin's lipid-film barrier. The effectiveness is increased with smaller nanoparticle size and enhanced skin permeation of loaded compounds. This study optimized the Polysorbate Sorbitan Phase-Inversion Temperature method to engineer ultrasmall solid-lipid nanoparticles loaded with α-tocopherol for cosmetic application.
Article
Biochemistry & Molecular Biology
Andrea Bianconi, Luca Francesco Salvati, Andrea Perrelli, Chiara Ferraris, Armando Massara, Massimiliano Minardi, Gelsomina Aruta, Miriam Rosso, Barbara Massa Micon, Diego Garbossa, Saverio Francesco Retta
Summary: This case report highlights the possibility of long-term distant recurrence of hemorrhagic sCCMs associated with a DVA, suggesting that such recurrence is secondary to focal sterile inflammatory conditions generated by the DVA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
